Donepezil hydrochloride-reinforced cellulose nanocrystal-aggregated gel structure for long-acting drug delivery

Jeong, Da In; Kim, Sungyun; Kim, Min-Hwan; Yoon, In‐Soo; Lee, Seung Hwan; Kim, Dae‐Duk; Cho, Hyun‐Jong

doi:10.1016/j.carbpol.2022.119887

Cited by 13 publications

(8 citation statements)

References 49 publications

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“…Moreover, a cellulose nanocrystal aggregated gel containing donepezil was constructed for sustained release at physiological pH, with assessments of gelation, injectability, viscoelasticity, and drug release kinetics. In vivo studies showed that this gel extended the drug’s half-life and offered sustained release compared to standard formulations, indicating a novel method for prolonged drug delivery and potentially enhancing the treatment efficacy for conditions like Alzheimer’s disease [ 56 ].…”

Section: Long-acting Gels For Advanced Drug Deliverymentioning

confidence: 99%

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Long-Acting Gel Formulations: Advancing Drug Delivery across Diverse Therapeutic Areas

Omidian,

Wilson

2024

Pharmaceuticals

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This multifaceted landscape of long-acting gels in diverse medical fields, aims to enhance therapeutic outcomes through localized treatment and controlled drug release. The objective involves advancements spanning cancer treatment, immunotherapy, diabetes management, neuroendocrine disorders, ophthalmic applications, contraception, HIV/AIDS treatment, chronic diseases, wound care, and antimicrobial treatments. It explores the potential of long-acting gels to offer sustained and extended drug release, targeted therapy, and innovative administration routes while addressing limitations such as scalability challenges and regulatory hurdles. Future directions focus on personalized therapies, biodegradability, combination therapies, interdisciplinary innovation, regulatory considerations, and patient-centric development. This comprehensive review highlights the pivotal role of long-acting gels in transforming therapeutic approaches and improving patient outcomes across various medical conditions.

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Section: Long-acting Gels For Advanced Drug Deliverymentioning

confidence: 99%

“…The progress in enhanced drug delivery technologies and targeted therapies aims to improve the bioavailability, stability, and patient compliance of treatments for various conditions, propelling the development of long-acting gels to meet these complex therapeutic needs [ 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ].…”

Section: Introductionmentioning

confidence: 99%

Long-Acting Gel Formulations: Advancing Drug Delivery across Diverse Therapeutic Areas

Omidian,

Wilson

2024

Pharmaceuticals

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“…The most recent method proposed by [ 224 ] used inversion and tilting methods to produce a crosslinked CNC/donepezil hydrochloride (cCNC/DPZ) hydrogel to evaluate long-acting drug delivery through subcutaneous injection and reported that the addition of DPZ to the CNC dispersion caused gel aggregation, and pH control of the CNC/DPZ hydrogel increased elastic modulus. In any case, the cCNC/DPZ hydrogel showed a longer half-life, high mean residence time, and lower C max values compared to the DPZ and CNC/DPZ hydrogel in a pharmacokinetic study [ 224 ].…”

Section: Nanocellulose Npsmentioning

confidence: 99%

Recent Development of Nanomaterials for Transdermal Drug Delivery

et al. 2023

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Nano-engineered medical products first appeared in the last decade. The current research in this area focuses on developing safe drugs with minimal adverse effects associated with the pharmacologically active cargo. Transdermal drug delivery, an alternative to oral administration, offers patient convenience, avoids first-pass hepatic metabolism, provides local targeting, and reduces effective drug toxicities. Nanomaterials provide alternatives to conventional transdermal drug delivery including patches, gels, sprays, and lotions, but it is crucial to understand the transport mechanisms involved. This article reviews the recent research trends in transdermal drug delivery and emphasizes the mechanisms and nano-formulations currently in vogue.

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“…The particles demonstrated excellent abilities in inhibiting inflammation, promoting granulation tissue formation, collagen deposition, and angiogenesis, thus accelerating wound healing. Jeong et al [145] developed a donepezil hydrochloride (DPZ)-reinforced CNC hydrogel with pH control for subcutaneous drug delivery. The authors fabricated an aggregated CNC gel by reducing electrostatic repulsion between CNC particles with DPZ and adjusting the pH to 7.7.…”

Section: Insights and Perspectivesmentioning

confidence: 99%

Cellulose Nanocrystal (CNC) Gels: A Review

Veloso

Azevedo

Teixeira

et al. 2023

Gels

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The aim of this article is to review the research conducted in the field of aqueous and polymer composites cellulose nanocrystal (CNC) gels. The experimental techniques employed to characterize the rheological behavior of these materials will be summarized, and the main advantages of using CNC gels will also be addressed in this review. In addition, research devoted to the use of numerical simulation methodologies to describe the production of CNC-based materials, e.g., in 3D printing, is also discussed. Finally, this paper also discusses the application of CNC gels along with additives such as cross-linking agents, which can represent an enormous opportunity to develop improved materials for manufacturing processes.

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Donepezil hydrochloride-reinforced cellulose nanocrystal-aggregated gel structure for long-acting drug delivery

Cited by 13 publications

References 49 publications

Long-Acting Gel Formulations: Advancing Drug Delivery across Diverse Therapeutic Areas

Long-Acting Gel Formulations: Advancing Drug Delivery across Diverse Therapeutic Areas

Recent Development of Nanomaterials for Transdermal Drug Delivery

Cellulose Nanocrystal (CNC) Gels: A Review

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