Donnees Nouvelles Sur Les Modalites Chronologiques Et Quantitatives De l'ACTION Antiovulatoire Du Meprobamate Chez La Ratte

Abstract

The effects of meprobamate on the ovary were studied in two different strains of virgin 4-day cyclic Wistar rats. Antiovulatory action of the drug was observed when administered on the morning of prooestrus between 9 and 12 a. m. This action was shown to be quantitative and depending on the time of the injection. A difference in the activity of meprobamate was evidenced between the two strains experimented. This action of the tranquillizer was supposed to be mediated by neural structures. Only weak antiovulatory effects of the meprobamate were observed when the drug was administered after 4.30 p. m. on the day of prooestrus. Furthermore the ovulatory action of exogenous gonadotrophin was not prevented by meprobamate.