Donor cell leukemia: insight into cancer stem cells and the stem cell niche

Flynn, Catherine M.; Kaufman, Dan S.

doi:10.1182/blood-2006-07-021980

Cited by 127 publications

(115 citation statements)

References 64 publications

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“…The ultimate network that constitutes the basic unit of tissue physiology involves several signaling cascades that mediate the balanced response of the stem cell to the need of the organism. But controversies arise when the dysregulation induces pathological conditions imposing aberrant functions of stem cells or other targets (2,5,(11)(12)(13)(14)(15)(16).…”

Section: Stem Cells and Their Microenvironment: The Nichementioning

confidence: 99%

Stem Cell Niche, the Microenvironment and Immunological Crosstalk

Law¹,

Chaudhuri²

2008

Cell Mol Immunol

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Section: Stem Cells and Their Microenvironment: The Nichementioning

confidence: 99%

Stem Cell Niche, the Microenvironment and Immunological Crosstalk

Law¹,

Chaudhuri²

2008

Cell Mol Immunol

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“…It is theorized that cancer may only be fully eradicated by the elimination of these tumor-initiating cells, therefore understanding their role in tumorigenesis is crucial [31]. Since the cancer stem cell hypothesis originated, cancer stem cells have been identified in tumors of the breast, brain, colon, and blood, among others [2,8,16,17,21].…”

Section: Introductionmentioning

confidence: 99%

A Maturity-Structured Mathematical Model of Mutation, Acquisition in the Absence of Homeostatic Regulation

Gentry

Ashkenazi

Jackson

2009

Math. Model. Nat. Phenom.

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Abstract. Most mammalian tissues are organized into a hierarchical structure of stem, progenitor, and differentiated cells. Tumors exhibit similar hierarchy, even if it is abnormal in comparison with healthy tissue. In particular, it is believed that a small population of cancer stem cells drives tumorigenesis in certain malignancies. These cancer stem cells are derived from transformed stem cells or mutated progenitors that have acquired stem-cell qualities, specifically the ability to selfrenew. Similar to their normal counterparts, cancer stem cells are long-lived, can self-renew and differentiate, albeit aberrantly, and are capable of generating tissue, resulting in tumor formation. Although identified and characterized in several forms of malignancy, the specific multi-step process that causes the formation of cancer stem cells is uncertain. Here, a maturity-structured mathematical model is developed to investigate the sequential order of mutations that causes the fastest emergence of cancer stem cells. Using model predictions, we discuss conditions for which genetic instability significantly speeds cancer onset and suggest that unbalanced stem-cell selfrenewal and inhibition of progenitor differentiation contribute to aggressive forms of cancer. To our knowledge, this is the first continuous maturity-structured mathematical model used to investigate mutation acquisition within hierarchical tissue in order to address implications of cancer stem cells in tumorigenesis.

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“…Secondary leukemia-derived donor cells, designated donor cell leukemia (DCL), may occur after allogeneic hematopoietic stem cell transplantation (allo-HSCT) (1)(2)(3). Reported cases with DCL, mainly acute myeloid leukemia after umbilical cord blood transplantation, are increasing according to the recent advance of diagnostic procedures such as short tandem repeat (STR) testing (4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Occurrence of Donor Cell-derived Lymphoid Blast Crisis 24 Years Following Related Bone Marrow Transplantation for Chronic Myeloid Leukemia

et al. 2016

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We herein report a unique case of donor cell leukemia (DCL), as donor cell-derived lymphoid blast crisis of chronic myeloid leukemia (CML) was observed 24 years after related bone marrow transplantation for CML in the chronic phase. Short tandem repeat testing of the leukemic blast sample revealed full donor chimerism, strongly indicative of DCL. The original donor is healthy with a normal complete blood cell count for the past 24 years. This rare case may provide a precious opportunity to consider not only the underlying mechanism of DCL, but also the pathogenesis of CML.

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Donor cell leukemia: insight into cancer stem cells and the stem cell niche

Cited by 127 publications

References 64 publications

Stem Cell Niche, the Microenvironment and Immunological Crosstalk

Stem Cell Niche, the Microenvironment and Immunological Crosstalk

A Maturity-Structured Mathematical Model of Mutation, Acquisition in the Absence of Homeostatic Regulation

Occurrence of Donor Cell-derived Lymphoid Blast Crisis 24 Years Following Related Bone Marrow Transplantation for Chronic Myeloid Leukemia

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