Donor demographic and laboratory predictors of single donor platelet yield

Arun, R; Yashovardhan, A; Deepthi, K; Suresh, B; Babu, KV Sreedhar; Jothibai, DS

doi:10.4103/2277-5706.241527

Cited by 4 publications

(2 citation statements)

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“…We found no significant associations between age and other parameters, in accordance with other authors who also found no influences of age and sex on the platelet concentration or on the concentration of growth factors. [12][13][14][15] In contrast, however, some authors found that platelet yield and growth factor concentration increased with age. [16,17] The findings of previous studies that analyzed age in relation to other variables are shown in Table 3.…”

Section: Discussionmentioning

confidence: 99%

“…Further studies should therefore be undertaken to evaluate the above-mentioned parameters, with a control group for product standardization. Furthermore, we did Taniguchi et al [12] PDGF-BB r = -0.32; P = 0.049 (Spearman's correlation) Geetha et al [16] Platelet yield r = 0.38; P < 0.05 (Pearson's correlation) Evanson et al [17] PDGF-BB P < 0.05 (Mann-Whitney rank-sum test) Cho et al [13] PDGF-BB r = -0.32; P < 0.05 (Pearson's correlation) Dragoo et al [14] PDGF-BB r = -0.519; P < 0.001 (Pearson's correlation) Arun et al [15] Platelet yield r = -0.229; P = 0.009 (Pearson's correlation) PDGF = platelet-derived growth factor.…”

Section: Limitationsmentioning

confidence: 99%

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Factors affecting the quantity and quality of platelet-rich plasma and platelet-derived growth factor-BB: an observational study

Verma¹,

Kandwal

Negi³

et al. 2021

J Bio-X Res

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Objective: Platelet-rich plasma (PRP) releases growth factors upon activation, which in turn accelerates healing and regeneration of the target tissue. However, PRP composition may vary according to the patient's demographics, and wider applications of PRP warrant product standardization. The current study aimed to examine variables influencing the platelet-derived growth factor BB (PDGF-BB) concentration in PRP. Methods: This observational study was conducted in the Department of Pathology and Dentistry at Swami Rama Himalayan University, a tertiary care hospital in northern India from December 2016 to November 2017. PRP was prepared from 40 mL of whole blood from 35 individuals (22 women, 13 men). Platelet counts, platelet indices (platelet distribution width, mean platelet volume) and PDGF-BB levels were measured, and platelet yield, platelet dose, and growth factor dose in PRP were also calculated. All parameters were analyzed using Pearson's correlation coefficient. The association between PDGF-BB and PRP platelet count was evaluated using logistic regression. This study was approved by the Ethics Committee of Swami Rama Himalayan University (SRHU/HIMS/ETHICS/2016/103) on September 7, 2016. Results: The mean platelet count, PDGF-BB concentration, platelet yield, platelet dose, and growth factor dose in PRP were 1317 × 109/L, 30 ± 9.89ng/mL, 71.62 ± 28.34%, 6.5 ± 3.5 × 109, and 159.62 ± 52.39ng/mL, respectively. Linear regression analysis indicated that PRP platelet counts were a good predictor for PGDF-BB (P < 0.05; adjusted R 2 = 0.96. PRP platelet count was significantly positively correlated with PDGF-BB concentration (r = 0.74, P < 0.001), platelet yield (r = 0.80, P < 0.001), platelet dose (r = 1, P < 0.001), and growth factor dose (r = 0.74, P < 0.001). Conclusions: PRP has wide clinical applications associated with its healing and regenerative properties, and both the quality and quantity of PRP thus need to be standardized as per the requirements. Evaluating variables affecting PRP will thus aid pathologists and clinical practitioners.

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Section: Discussionmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Factors affecting the quantity and quality of platelet-rich plasma and platelet-derived growth factor-BB: an observational study

Verma¹,

Kandwal

Negi³

et al. 2021

J Bio-X Res

View full text Add to dashboard Cite

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Evaluation of Factors Affecting the Quantity and Quality of Platelet-Rich Plasma and Platelet-Derived Growth Factor-BB

Verma,

Sharma,

Negi

et al. 2021

CHRISMED Journal of Health and Research

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Context: Platelet-rich plasma (PRP) releases growth factors (GFs) upon activation which accelerates the healing and regeneration in the target tissue. Wider applications of PRP warrant product standardization. PRP compositions may vary according to the patient's demographics and the constituents of PRP. Aims: Our study aimed to assess the correlations between age, gender, platelet counts, platelet indices, platelet yield, platelet dose, GF dose, and platelet-derived GF-BB (PDGF-BB) concentration. Settings and Design: This was an experimental study done in the Department of Pathology along with the Department of Dentistry at a tertiary care hospital in North India. Subjects and Methods: PRP was prepared from 40 ml of whole blood. Platelet counts, platelet indices (LH 750 coulter analyzer, Florida, USA), and PDGF-BB levels (enzyme-linked immunosorbent assay, Qayee Bio., Ltd, China) were measured. Platelet yield (%), platelet dose (×106), and GF dose (×1012) in PRP were also calculated. Statistical Analysis Used: All the parameters were analyzed using Pearson's correlation coefficient and linear regression. Paired t-test and Mann–Whitney test were used for two-group analysis. Results: Mean platelet count, PDGF-BB concentration, platelet yield, platelet dose, and GF dose in PRP were 1317 × 103/mm3, 30 ± 9.89 ng/ml, 71.62 ± 28.34%, 6.5 ± 3.5 × 109, and 159.62 ± 52.39 ng/ml, respectively. PRP platelet counts were positively correlated with PDGF-BB concentration, platelet yield, platelet dose, and GF dose. Conclusions: Of all the parameters, PDGF-BB concentration, platelet yield, platelet dose, and GF dose showed a positive correlation with PRP platelet count. Age, gender, and platelet indices had no significant influence.

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Are donor predonation variables related to the quality of single donor platelets? – A tertiary care center experience

Chatterjee¹,

Sehgal

Bhardwaj

et al. 2021

Journal of Medical Society

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Introduction: Platelets are the most common product collected by apheresis. The product obtained is called single donor platelets (SDPs). The quality of the SDP is determined by the platelet yield (that is platelet count of the SDP product), which in turn directly influences the patient recovery. Materials and Methods: In the present study, donor demographic and complete blood count parameters were studied and their influence on the yield of the SDP was analyzed. With such an analysis, a better quality product (with a good platelet yield) can be obtained consequently improving clinical outcome. This would allow prolonging intervals between transfusions. Results: Parameters such as height, weight, and body mass index did not statistically influence the platelet yield in this study, unlike the results obtained by past studies. The most consistent parameter found to influence the platelet yield was platelet count of the donor. Healthy donors with high platelet counts can yield better platelet yield in SDPs in a shorter time and therefore improve the clinical outcome in patients with thrombocytopenia. Conclusion: It is important to consider hematological characteristics of the donors on an individual basis so as to ensure a good quality of the plateletpheresis product.

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Donor demographic and laboratory predictors of single donor platelet yield

Cited by 4 publications

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Factors affecting the quantity and quality of platelet-rich plasma and platelet-derived growth factor-BB: an observational study

Factors affecting the quantity and quality of platelet-rich plasma and platelet-derived growth factor-BB: an observational study

Evaluation of Factors Affecting the Quantity and Quality of Platelet-Rich Plasma and Platelet-Derived Growth Factor-BB

Are donor predonation variables related to the quality of single donor platelets? – A tertiary care center experience

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