Donor related corneal graft infection: a review of literature and preventive strategies

Deogaonkar, Ketan; Roy, Aravind

doi:10.1080/08820538.2022.2095873

Cited by 4 publications

(1 citation statement)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this perspective, nanotechnology emerges as a potential alternative for efficient ocular drug delivery, leading to the development of one of the first FDA approved nanoformulations, a liposomal formulation of the drug, amBisome. [13,14] Despite the development of various biodegradable nanoformulations of amphotericin B, [15][16][17][18][19][20][21] they are limited in their clinical outcomes owing to emergence of multi-drug resistance in fungal microbial species, [22][23][24][25][26] indicating the need for developing further advanced therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

Ethosomal Nanoformulations for Combinational Photothermal Therapy of Fungal Keratitis

Mudigunda

Sankaranarayanan

Veeresh

et al. 2023

Advanced Therapeutics

View full text Add to dashboard Cite

Fungal keratitis/mycotic keratitis or keratomycosis, is characterized by the inflammation of underlying stroma of corneal epithelium due to fungal infection. Multi‐drug resistance and subsequent recurrence of infection limits the clinical outcomes of anti‐fungal agents such as Amphotericin B and Natamycin; and therefore, demands research on newer anti‐microbial strategies. In this study, the authors have synthesized and characterized ethosomes (IAEs) encapsulating a NIR dye, Indocyanine green (ICG), and an anti‐fungal drug, Amphotericin B, for a combinational photothermal therapy of fungal keratitis. The in vitro anti‐fungal efficacy of the IAEs is validated against Candida albicans by colony formation assay, calcofluor staining, and SEM analysis. The results indicate that the IAEs, upon NIR irradiation, displays a synergistic anti‐fungal efficacy. The IAEs are highly biocompatible when tested using a human corneal epithelial (HCE) cell line model (in vitro) and a Draize eye test model in rabbits (in vivo). Further, it is observed that the IAEs,upon NIR laser exposure significantly eliminate the fungal infection in rat model of occular fungal keratitis. The research indicates that the IAEs nano‐formulation exhibits a synergistic and sustained anti‐fungal effect paving its way for further translation from bench to bedside for the efficient management of fungal keratitis.

show abstract

Section: Introductionmentioning

confidence: 99%

Ethosomal Nanoformulations for Combinational Photothermal Therapy of Fungal Keratitis

Mudigunda

Sankaranarayanan

Veeresh

et al. 2023

Advanced Therapeutics

View full text Add to dashboard Cite

show abstract

Synergistic activity of clioquinol with voriconazole and amphotericin B against fungi of interest in eye infections

Reginatto,

Agostinetto,

Teixeira

et al. 2024

Journal of Medical Mycology

View full text Add to dashboard Cite

Effect of Double Povidone-Iodine Wash on Rate of Positive Donor Corneoscleral Rim Cultures: A 7-Year Eye Bank Analysis

Tran,

Fraser,

Gillmor

et al. 2023

Eye Banking and Corneal Transplantation

View full text Add to dashboard Cite

Introduction: Starting October 2018, the Eye Bank Association of America modified the national standard protocol to incorporate a double povidone-iodine (P-I) wash at the time of procurement. Purpose: To determine if double P-I wash resulted in a reduced rate of positive donor rim cultures. Methods: A comprehensive database review was performed on consecutive corneoscleral tissue handled by The Eye-Bank for Sight Restoration (New York, NY) from January 2015 to December 2021. The primary outcome was the rate of positive corneoscleral rim cultures for bacteria or fungus. Secondary outcomes included rate of postoperative infection (eg, keratitis or endophthalmitis). For analysis, statistical significance was determined as P < 0.05. Results: Of 6079 corneal transplants performed, 3491 were done before implementation of double P-I wash with a total culture positive rate of 0.43%. There were 2588 corneal transplants performed after implementation of double P-I wash with a total positive culture rate of 0.23%, which is a significant reduction (Poisson regression incidence rate ratio [IRR] 0.35 [95% CI 0.089–0.61], P = 0.007). The most common organisms preimplementation were Candida species (46.7% of culture-positive rims), whereas no candida species were isolated postimplementation (logit regression, P = 0.034). Cutibacterium acnes culture positivity rate increased postimplementation to 50.0% versus 13.3% preimplementation (logit regression, P = 0.116). The rate of postoperative infection was 1.55% and 1.00% for preimplementation and postimplementation, respectively (IRR 0.30 [95% CI, 0.18–0.50], P < 0.001). Conclusions: The use of double P-I wash was associated with a decrease in the rate of positive corneoscleral donor rim cultures and a decrease in the rate of postoperative infection.

show abstract

Donor related corneal graft infection: a review of literature and preventive strategies

Cited by 4 publications

References 43 publications

Ethosomal Nanoformulations for Combinational Photothermal Therapy of Fungal Keratitis

Ethosomal Nanoformulations for Combinational Photothermal Therapy of Fungal Keratitis

Synergistic activity of clioquinol with voriconazole and amphotericin B against fungi of interest in eye infections

Effect of Double Povidone-Iodine Wash on Rate of Positive Donor Corneoscleral Rim Cultures: A 7-Year Eye Bank Analysis

Contact Info

Product

Resources

About