Dopamine and Dopamine Receptors in Alzheimer's Disease: A Systematic Review and Network Meta-Analysis

Pan, Xiongfeng; Kaminga, Atipatsa Chiwanda; Wen, Shi Wu; Wu, Xinyin; Acheampong, Kwabena; Liu, Aizhong

doi:10.3389/fnagi.2019.00175

Cited by 177 publications

(144 citation statements)

References 72 publications

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“…When the random-effects model was satisfied, the network meta-analysis, with consistency assumption, was conducted by the Markov-chain Monte Carlo method in Stata version 15.0, using the network command and self-programmed Stata routines, to compare the effects of multiple-correction chemokines. The first 20,000 iterations were discarded, and additional 50,000 iterations were executed (12,13). Moreover, vague priors were used in the network analysis, and the average residual deviation was used to estimate the goodness of fit.…”

Section: Discussionmentioning

confidence: 99%

Chemokines in Non-alcoholic Fatty Liver Disease: A Systematic Review and Network Meta-Analysis

et al. 2020

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Background: Previous results on the relationship between non-alcoholic fatty liver disease (NAFLD) and chemokine concentrations were inconsistent. The purpose of this network meta-analysis was to evaluate the link between chemokine system and NAFLD. Methods: Relevant data, published not later than June 31, 2019, were searched in the databases of PubMed, Embase, Cochrane Library, and Web of Science. A network meta-analysis was used to rank the chemokines by surface under the cumulative ranking (SUCRA) probabilities. In addition, standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated as group differences in the chemokine concentrations. Results: The search in the databases identified 46 relevant studies that investigated the relationship between 15 different chemokines and NAFLD using 4,753 patients and 4,059 controls. Results from the network meta-analysis showed that the concentrations of CCL2 and CXCL8 in the non-alcoholic fatty liver (NAFL) group was significantly higher than that in the control group (SMDs of 1.51 and 1.95, respectively), and the concentrations of CCL3, CCL4, CCL20, CXCL8, and CXCL10 in the non-alcoholic steatohepatitis (NASH) group was significantly higher than that in the control group (SMDs of 0.90, 2.05, 2.16, 0.91, and 1.46, respectively). SUCRA probabilities showed that CXCL8 had the highest rank in NAFL for all chemokines and CCL20 had the highest rank in NASH for all chemokines. Conclusion: Elevated concentrations of CCL2, CCL4, CCL20, CXCL8, and CXCL10 may be associated with NAFL or NASH. In this regard, more population-based studies are needed to ascertain this hypothesis.

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Section: Discussionmentioning

confidence: 99%

Chemokines in Non-alcoholic Fatty Liver Disease: A Systematic Review and Network Meta-Analysis

et al. 2020

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“…How the FAD transgenes start this vicious cycle was not resolved so far, however, it is interesting that decreased level of dopaminergic neurotransmitters and dopamine receptors in the CNS have been associated with AD progression. 108 If this is also the case for enteric neurons in AD model mice and patients has to be elucidated in the future. Besides Apoa1, also Abca1 was found to be differentially regulated at 2 months of age in colonic tissue from the 5xFAD mouse model.…”

Section: F I G U R Ementioning

confidence: 99%

Alzheimer's disease in the gut—Major changes in the gut of 5xFAD model mice with ApoA1 as potential key player

Stoye

Guilherme

2020

FASEB j.

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Alzheimer's disease (AD) affects around 33 million people worldwide, which makes it the most prominent form of dementia. The main focus of AD research has been on the central nervous system (CNS) for long, but in recent years, the gut gained more attention. The intestinal tract is innervated by the enteric nervous system (ENS), built of numerous different types of neurons showing great similarity to neurons of the CNS. It already has been demonstrated that the amyloid precursor protein, which plays a major role in AD pathology, is also expressed in these cells. We analyzed gut tissue of AD model mice (5xFAD) and the respective wild‐type littermates at different pathological stages: pre‐pathological, early pathological and late pathological. Our results show significant difference in function of the intestine of 5xFAD mice as compared to wild‐type mice. Using a pathway array detecting 84 AD‐related gene products, we found ApoA1 expression significantly altered in colon tissue of 5xFAD mice. Furthermore, we unveil ApoA1's beneficial impact on cell viability and calcium homeostasis of cultured enteric neurons of 5xFAD animals. With this study, we demonstrate that the intestine is altered in AD‐like pathology and that ApoA1 might be one key player within the gut.

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“…Furthermore, the dopaminergic system has been intensively studied as a key neurotransmitter involved with emotion and cognition ( Nardone et al , 2014 ). New findings on the relation of dopamine neurons in AD start to emerge as well ( Krashia et al , 2019 ; Pan et al , 2019 ). Both dopaminergic and serotonergic can be associated to AD through the calcium pathway.…”

Section: Discussionmentioning

confidence: 99%

PathWalks: identifying pathway communities using a disease-related map of integrated information

et al. 2020

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Abstract Motivation Understanding the underlying biological mechanisms and respective interactions of a disease remains an elusive, time consuming and costly task. Computational methodologies that propose pathway/mechanism communities and reveal respective relationships can be of great value as they can help expedite the process of identifying how perturbations in a single pathway can affect other pathways. Results We present a random-walks-based methodology called PathWalks, where a walker crosses a pathway-to-pathway network under the guidance of a disease-related map. The latter is a gene network that we construct by integrating multi-source information regarding a specific disease. The most frequent trajectories highlight communities of pathways that are expected to be strongly related to the disease under study. We apply the PathWalks methodology on Alzheimer's disease and idiopathic pulmonary fibrosis and establish that it can highlight pathways that are also identified by other pathway analysis tools as well as are backed through bibliographic references. More importantly, PathWalks produces additional new pathways that are functionally connected with those already established, giving insight for further experimentation. Availability and implementation https://github.com/vagkaratzas/PathWalks. Supplementary information Supplementary data are available at Bioinformatics online.

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Dopamine and Dopamine Receptors in Alzheimer's Disease: A Systematic Review and Network Meta-Analysis

Cited by 177 publications

References 72 publications

Chemokines in Non-alcoholic Fatty Liver Disease: A Systematic Review and Network Meta-Analysis

Chemokines in Non-alcoholic Fatty Liver Disease: A Systematic Review and Network Meta-Analysis

Alzheimer's disease in the gut—Major changes in the gut of 5xFAD model mice with ApoA1 as potential key player

PathWalks: identifying pathway communities using a disease-related map of integrated information

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