Dopamine‐containing axons supplying the arterio‐venous anastomoses of the canine paw pad

Bell, Christopher; Lang, W.J.; Laska, F. J.

doi:10.1111/j.1471-4159.1978.tb06259.x

Cited by 45 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the existence of a specific receptor is not a self-evident prerequisite for a substance to be located in an independent neurone, though it could be for a substance to act as a transmitter or co-transmitter, it can be speculated that in those areas where dopamine was ascribed to non-noradrenergic neurones the amine could exist as a transmitter, or cotransmitter, in sympathetic neurones and not necessarily in 'independent' dopaminergic neurones. One particular exception seems to be the nervous supply to the canine paw pads where substantial evidence has been presented in favour of the existence of an independent dopaminergic innervation (Bell & Lang, 1974;Bell et al, 1975;1978a;Bell, 1982b).…”

Section: Discussionmentioning

confidence: 99%

Dopamine released from nerve terminals activates prejunctional dopamine receptors in dog mesenteric arterial vessels

Soares-da-Silva

1987

British J Pharmacology

View full text Add to dashboard Cite

1The fractional release of dopamine and noradrenaline (NA) from the main trunk of the dog mesenteric artery and its proximal branches, when elicited by K+ (52 mM), was measured by high pressure liquid chromatography with electrochemical detection. 2 K+-induced depolarization released both dopamine and NA. For the main trunk of the mesenteric artery, the fractional release ofdopamine and NA were ofthe same order ofmagnitude, whereas for the proximal branches dopamine fractional release was significantly lower than that of NA.3 Phentolamine (0.2 pM) significantly increased dopamine and NA release in both segments of the mesenteric artery. However, for the proximal branches the effect of phentolamine on dopamine and NA release was greater than that observed in the main trunk.4 Sulpiride (1 juM) significantly increased dopamine and NA release in the proximal branches of the mesenteric artery, whereas in the main trunk sulpiride did not increase amine release. In the proximal branches of the mesenteric artery, sulpiride significantly enhanced dopamine and NA fractional release even after it had been augmented by phentolamine.5 Apomorphine (0.3 gM) significantly reduced dopamine and NA release in both segments of the mesenteric artery under study; this effect was abolished by sulpiride but not by phentolamine. 6 These results suggest that dopamine and NA released during depolarization by K+ activate prejunctional dopamine and a-adrenoceptors, respectively, thereby playing a role in the control of transmitter release.

show abstract

Section: Discussionmentioning

confidence: 99%

Dopamine released from nerve terminals activates prejunctional dopamine receptors in dog mesenteric arterial vessels

Soares-da-Silva

1987

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…There is now growing evidence that it may function as a neurotransmitter and/or cotransmitter in some peripheral tissues (Lackovic & Neff, 1983). For instance, dog kidney and paw pad appear to receive dopaminergic vasodilatory neurones (Bell & Lang, 1973Bell, Lang & Laska, 1978;Dinerstein et al, 1979). Despite reports of uterine dopamine (Swedin & Brudin, 1968 ;Lackovic et ai, 1982) there is limited information on its potential functional significance.…”

Section: Discussionmentioning

confidence: 99%

Regional changes in catecholamine content of the pregnant uterus

Arkinstall¹,

Jones²

1985

Reproduction

View full text Add to dashboard Cite

Summary. High-pressure liquid chromatography with electrochemical detection was used to identify and measure catecholamines in rat, rabbit, sheep, guinea-pig and human uteri and follow changes with pregnancy. Noradrenaline was consistently the major catecholamine and pregnancy caused a regionally specific fall in its concentration which, in rat, rabbit and guinea-pig, was associated with a decline in total content. Adrenaline was undetectable (<10 pmol/g myometrium) in all species and at all gestational ages studied. Dopamine and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) were detected at high concentrations in guinea-pig and particularly sheep uterus. In guinea-pig uterus the dopamine/DOPAC ratio fell dramatically with pregnancy, suggesting that increased quantities of dopamine were released and catabolized. The dopamine/noradrenaline ratios suggested that dopamine is stored with noradrenaline in adrenergic neurones in guinea-pig myometrium and within an additional neuronal or cellular store(s) in sheep uterus.

show abstract

“…Thus receptors involved in the ergotamineinduced reduction of arteriovenous anastomotic blood flow in the carotid vascular bed are yet to be characterized. In this context it may be recalled that 5-HT can act on receptors unrelated to 5-HT1-like, 5-HT2 or 5-HT3 types in isolated papillary muscle of kitten (Kaumann, 1985) and in the pig heart (Bom et al, 1988) and that vasodilator dopamine receptors have been described on arteriovenous anastomoses in the canine paw pad (Bell et al, 1978;Bell & Lang, 1979). Whether ergotamine can act on these receptors is not yet known.…”

Section: Effects Ofergotaminementioning

confidence: 99%

Reduction of cephalic arteriovenous shunting by ergotamine is not mediated by 5‐HT₁‐like or 5‐HT₂ receptors

Bom

Heiligers

Saxena

et al. 1989

British J Pharmacology

View full text Add to dashboard Cite

1 The potent, antimigraine drug ergotamine has affinity for both 5-HT1 and 5-HT2 binding sites and constricts arteriovenous anastomoses. Since 5-HT also constricts arteriovenous anastomoses (mainly via 5-HT1-like receptors), this study investigates the involvement of 5-HT receptors in the ergotamine-induced reduction of arteriovenous shunting in the carotid circulation of the cat and pig. 2 In the cat, ergotamine (3, 10 and 30 ug kg 1, i.v.) reduced carotid blood flow, predominantly by a reduction in arteriovenous anastomotic blood flow. Pretreatment with ketanserin (0.5 mgkg 1, i.v.) or methiothepin (1 mg kg-', i.v.) did not antagonize the effects of ergotamine.3 In the pig, ergotamine (2.5, 5, 10 and 20pgkg-', i.v.) also reduced carotid blood flow and arteriovenous shunting, which was not affected by pretreatment with methiothepin (1 mg kg-1, i.v.). 4 These results suggest that the reduction by ergotamine in the shunting of carotid arterial blood via cephalic arteriovenous anastomoses is not mediated by 5-HT1-like or 5-HT2 receptors.

show abstract

Dopamine‐containing axons supplying the arterio‐venous anastomoses of the canine paw pad

Cited by 45 publications

References 17 publications

Dopamine released from nerve terminals activates prejunctional dopamine receptors in dog mesenteric arterial vessels

Dopamine released from nerve terminals activates prejunctional dopamine receptors in dog mesenteric arterial vessels

Regional changes in catecholamine content of the pregnant uterus

Reduction of cephalic arteriovenous shunting by ergotamine is not mediated by 5‐HT₁‐like or 5‐HT₂ receptors

Contact Info

Product

Resources

About

Dopamine‐containing axons supplying the arterio‐venous anastomoses of the canine paw pad

Cited by 45 publications

References 17 publications

Dopamine released from nerve terminals activates prejunctional dopamine receptors in dog mesenteric arterial vessels

Dopamine released from nerve terminals activates prejunctional dopamine receptors in dog mesenteric arterial vessels

Regional changes in catecholamine content of the pregnant uterus

Reduction of cephalic arteriovenous shunting by ergotamine is not mediated by 5‐HT1‐like or 5‐HT2 receptors

Contact Info

Product

Resources

About

Reduction of cephalic arteriovenous shunting by ergotamine is not mediated by 5‐HT₁‐like or 5‐HT₂ receptors