Regional changes in catecholamine content of the pregnant uterus

Arkinstall, S. J.; Jones, C. T.

doi:10.1530/jrf.0.0730547

Cited by 38 publications

(28 citation statements)

References 29 publications

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“…According to Zi´ba (Zi´ba and Dejneka 1996) dopamine administered intravenously to sheep sensitized by stilboestrol causes an increase in uterus myoelectrical activity. The research carried out by Arkinstall and Jones (1985) also confirms the presence of this catecholamine in the uterine smooth muscles of humans, rabbit, sheep, guinea pig and rat. According to Moustafa, activating the dopaminergic receptor with bromocriptine (a selective D 2 -agonist and weak partial agonist at the D 1 receptor) in both in vitro and in vivo experiments causes an increase in myometrial contraction in the early stage of rat pregnancy (Moustafa et al 1999;Clark and White 1987).…”

supporting

confidence: 57%

“…1991; Sheldrick and Flint 1985). Arkinstall and Jones (1985) indicated the presence of endogenous dopamine in uterus muscles, and Forsberg et al (1987) exhibited the influence of dopamine on rat uterus cervix contractility. According to Zi´ba and Dejneka (1996) dopamine stimulates uterine myoelectrical activity in sheep sensitized by stilboestrol and its stimulating effect is not carried out by dopaminergic receptors.…”

Section: Discussionmentioning

confidence: 98%

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Influence of Dopamine on Rat Uterine Motility in vitro

Czerski¹,

Zawadzki²,

Zawadzki³

et al. 2005

Acta Vet. Brno

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Czerski A., W. Zawadzki, M. Zawadzki, Z. Czerska: Influence of Dopamine on Rat Uterine Motility in vitro. Acta Vet. Brno 2005, 74: 9-15.The effect of dopamine on spontaneous rhythmic contractions of isolated rat uterine muscles was examined. The experiments were carried out on 25 female Buffalo rats aged between 4-6 months. Myometrial tissue (1.5-2 cm long) was set up in 4 isolated organ baths (20 ml) at 37 °C. After recording the pattern of myometrial tissue spontaneous motility: dopamine, domperidone, metoclopramide, clozapine, bromocriptine, prazosine, propranolol were added into the organ baths. The dose of the formulae was fixed in preliminary experiments. Myometrial strips incubated in the isolated organ baths had spontaneous motility for about 8 to 12 h. The spontaneous motility frequency amounted to about 1.15 ± 0.38 contractions per min. The contraction strength was on average 2.8 ± 0.45 grams.The addition of dopamine into the incubation bath organ at a concentration of 1.3·10 -4 mol/L significantly reduced the strength (63%, p < 0.001, to the value of 1.04 ± 0.18 grams) and frequency (27%, p < 0.01, to the value 0.84 ± 0.21 per minute) of spontaneous rhythmic contractions. The addition of dopamine at a concentration of 2.6·10 -4 mol/L totally inhibited the uterine spontaneous contractions. The attempt at blocking dopaminergic receptors with metoclopramide, domperidone and clozapine did not prevent uterus atony caused by the addition of dopamine. Uterus contractility was not affected by activating dopaminergic receptors with bromocriptine D 1 and D 2 receptors agonist, and the obtained recording exhibited no statistically significant differences in comparison to the initial recording. Simultaneous blocking of α 1 adrenergic receptors with prazosine and β adrenergic receptors with propranolol counteracted uterus atony after the addition of dopamine to the incubation bath organ.The results indicated a blocking influence of dopamine on uterus contractility in rats in vitro related to a concentration of dopamine and caused by activating adrenergic receptors with dopamine.

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supporting

confidence: 57%

Section: Discussionmentioning

confidence: 98%

Influence of Dopamine on Rat Uterine Motility in vitro

Czerski¹,

Zawadzki²,

Zawadzki³

et al. 2005

Acta Vet. Brno

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“…Cortisol output determined using this method was 94-3 + 2-0 % (n = 8) of that measured by radioimmunoassay. Adrenaline and noradrenaline were measured by high-pressure liquid chromatography after alumina extraction, essentially as described previously (Arkinstall & Jones, 1985).…”

Section: Analytical Proceduresmentioning

confidence: 99%

Secretion of corticotrophin releasing factor from the adrenal during splanchnic nerve stimulation in conscious calves.

Edwards¹,

Jones²

1988

The Journal of Physiology

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SUMMARY1. The output of corticotrophin releasing factor-like immunoreactivity (CRF) from the adrenal gland has been investigated using the 'adrenal clamp' technique in conscious calves.2. Stimulation of the peripheral end of the splanchnic nerve for 10 min increased the mean output of CRF progressively, so that it had risen by about twentyfold, to a peak incremental value of 24 +4 pmol min-' kg-' at 10 min. This response was significantly increased by stimulating in bursts at 40 Hz for 1 s at 10 s intervals, which raised the mean CRF output by 44+7 pmol min-' kg-' at 10 min (P < 0-05).3. The mean output of adrenaline and noradrenaline rose more abruptly in response to splanchnic nerve stimulation with peak incremental values realized within 2-5 min. However, the ratios of adrenal CRF to catecholamine output were closely similar during the later stages of stimulation (7-5-10 min). There was a similarly abrupt rise in adrenal cortisol output in response to splanchnic nerve stimulation which was, nevertheless, linearly related to arterial plasma ACTH concentration throughout.4. In hypophysectomized calves, administration of adrenocorticotrophic hormone (ACTH1-24) at a dose of 5 ng min-' kg-1 reduced the output of adrenal CRF in response to splanchnic nerve stimulation by about 50% (P < 0 05). 5. CRF isolated from adrenal venous effluent plasma, collected both at rest and during splanchnic nerve stimulation, was separated by reverse-phase high-pressure liquid chromatography and found to elute in a position identical to that of human 41CRF. This suggests that adrenal CRF is structurally closely similar to its pituitary counterpart.

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“…Catecholamines were measured by high-pressure liquid chromatography (Arkinstall & Jones, 1985); ACTH and cortisol were estimated by radioimmunoassay, as described previously (Abraham, Buster & Teller, 1972;Jones, Boddy, Robinson & Ratcliffe, 1977 …”

Section: Analytical Proceduresmentioning

confidence: 99%

The effect of splanchnic nerve section on the sensitivity of the adrenal cortex to adrenocorticotrophin in the calf.

Edwards

Jones

1987

The Journal of Physiology

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SUMMARY1. Adrenal cortical responses to adrenocorticotrophin (ACTH) in conscious 2-6-week-old calves, in which both splanchnic nerves had been cut at least 7 days previously, were compared with those of normal calves of the same age in order to discover whether splanchnic nerve section affects the sensitivity of the adrenal cortex to the trophin.2. In one series of experiments an increase in the release of endogenous ACTH was elicited by an i.v. infusion of noradrenaline (333 ng min-' kg-' for 10 min) and in another the concentration of ACTH in the plasma was artificially increased by infusing synthetic ACTH1l24 intravenously at either 5 or 10 ng min-' kg-' for 10 min.3. In all groups mean plasma ACTH was linearly related to mean plasma cortisol and the sensitivity of the adrenal steroidogenic response to ACTH was found to be substantially reduced 7 or more days after section of both splanchnic nerves.

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Regional changes in catecholamine content of the pregnant uterus

Cited by 38 publications

References 29 publications

Influence of Dopamine on Rat Uterine Motility in vitro

Influence of Dopamine on Rat Uterine Motility in vitro

Secretion of corticotrophin releasing factor from the adrenal during splanchnic nerve stimulation in conscious calves.

The effect of splanchnic nerve section on the sensitivity of the adrenal cortex to adrenocorticotrophin in the calf.

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