Dopamine D<sup>2</sup> receptor knockout mice develop features of Parkinson disease

Tinsley, Rogan B.; Bye, Chris R.; Parish, Clare L.; Tziotis-Vais, Angela; George, Sonia; Culvenor, Janetta G.; Li, Qiao‐Xin; Masters, Colin L.; Finkelstein, David I.; Horne, Malcolm

doi:10.1002/ana.21716

Cited by 44 publications

(40 citation statements)

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“…In this regard, recent theories have proposed that dopamine D2 dysregulation of the balance between direct and indirect striatal pathways is associated with motor cortical alterations and with motor symptoms like bradykinesia (Rodriguez-Oroz et al, 2009). Indeed, a series of studies provide experimental support for D2 receptor involvement in PD and for control of signal-to-noise in motor circuitry by striatal dopamine levels (Boraud et al, 2000;Drew et al, 2007;Filion et al, 1988;Goldberg et al, 2004;Tinsley et al, 2009). Consistently, primary motor cortex responses are increased in patients with PD (Cantello et al, 1996;Lefaucheur, 2005); exaggerated responses in the motor circuitry including the SMA are related to dopamine levels (Mattay et al, 2002) and striato-frontal connectivity (Jahanshahi et al, 2010).…”

Section: Discussionmentioning

confidence: 86%

D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans

et al. 2011

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Section: Discussionmentioning

confidence: 86%

D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans

et al. 2011

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“…eye growth may be associated with the energy consumption and vitreal glucose level (Feldkaemper et al 2000, IOVS ). D2R knockout mice develop features of Parkinson disease (Tinsley et al, 2009), prolactinoma (Cristina et al, 2006), chronic pituitary hyperplasia (Cristina et al, 2006) and a moderate decrease in MSH content (Kelly et al, 1997). Thus, extensive studies on possible side effects of DA on visual and systemic functions are necessary before DA agonists could be considered as an anti-myopic drug in children.…”

Section: Da Signaling and Myopia: Therapeutic Strategies And Clinimentioning

confidence: 99%

Dopamine signaling and myopia development: What are the key challenges

Zhou

Pardue

Iuvone

et al. 2017

Progress in Retinal and Eye Research

244

203

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In the face of an “epidemic” increase in myopia over the last decades and myopia prevalence predicted to reach 2.5 billion people by the end of this decade, there is an urgent need to develop effective and safe therapeutic interventions to slow down this “myopia booming” and prevent myopia-related complications and vision loss. Dopamine (DA) is an important neurotransmitter in the retina and mediates diverse functions including development, visual signaling, and refractive development. Inspired by the convergence of epidemiological and animal studies in support of the inverse relationship between outdoor activity and risk of developing myopia and by the close biological relationship between light exposure and dopamine release/signaling, we felt it is timely and important to critically review the role of DA in myopia development. This review will revisit several key points of evidence for and against DA mediating light control of myopia: 1) the causal role of extracellular retinal DA levels, 2) the mechanism and action of dopamine D1 and D2 receptors and 3) the roles of cellular/circuit retinal pathways. We examine the experiments that show causation by altering DA, DA receptors and visual pathways using pharmacological, transgenic, or visual environment approaches. Furthermore, we critically evaluate the safety issues of a DA-based treatment strategy and some approaches to address these issues. The review identifies the key questions and challenges in translating basic knowledge on DA signaling and myopia from animal studies into effective pharmacological treatments for myopia in children.

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“…In vivo modest accumulation of αSN induces the protective phases of the UPR and autophagy [67]. Overall, while there are significant methodological issues here relevant to isolated mitochondria versus intact cells, and cell lines relative to primary neurons, the dopaminergic neurotoxins rotenone and MPP + do have various actions eliciting PCD (see review [30]), and accumulation of αSN in its various forms may predispose neurons to injury by ER stress and/or autophagy [68].…”

Section: Mitochondrial Respiratory Complexes Oxidative Damage and Pcdmentioning

confidence: 99%

Oxidative Stress: Emerging Mitochondrial and Cellular Themes and Variations in Neuronal Injury

Higgins

Beart

Shin

et al. 2010

JAD

134

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Abstract. Oxidative stress plays a central role in neuronal injury and cell death in acute and chronic pathological conditions. The cellular responses to oxidative stress embrace changes in mitochondria and other organelles, notably endoplasmic reticulum, and can lead to a number of cell death paradigms, which cover a spectrum from apoptosis to necrosis and include autophagy. In Alzheimer's disease, and other pathologies including Parkinson's disease, protein aggregation provides further cellular stresses that can initiate or feed into the pathways to cell death engendered by oxidative stress. Specific attention is paid here to mitochondrial dysfunction and programmed cell death, and the diverse modes of cell death mediated by mitochondria under oxidative stress. Novel insights into cellular responses to neuronal oxidative stress from a range of different stressors can be gained by detailed transcriptomics analyses. Such studies at the cellular level provide the key for understanding the molecular and cellular pathways whereby neurons respond to oxidative stress and undergo injury and death. These considerations underpin the development of detailed knowledge in more complex integrated systems, up to the intact human bearing the neuropathology, facilitating therapeutic advances.

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Dopamine D² receptor knockout mice develop features of Parkinson disease

Abstract: Increased sprouting and DA turnover, as observed in PD and D(2)R(-/-) mice, augments LB-like inclusions and axonal degeneration of dopaminergic neurons. These changes are associated with ER stress and autophagy.

Cited by 44 publications

References 79 publications

D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans

D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans

Dopamine signaling and myopia development: What are the key challenges

Oxidative Stress: Emerging Mitochondrial and Cellular Themes and Variations in Neuronal Injury

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Dopamine D2 receptor knockout mice develop features of Parkinson disease

Abstract: Increased sprouting and DA turnover, as observed in PD and D(2)R(-/-) mice, augments LB-like inclusions and axonal degeneration of dopaminergic neurons. These changes are associated with ER stress and autophagy.

Cited by 44 publications

References 79 publications

D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans

D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans

Dopamine signaling and myopia development: What are the key challenges

Oxidative Stress: Emerging Mitochondrial and Cellular Themes and Variations in Neuronal Injury

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Product

Resources

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Dopamine D² receptor knockout mice develop features of Parkinson disease