Dopamine D2 receptor plays a role in memory function: implications of dopamine–acetylcholine interaction in the ventral hippocampus

Fujishiro, Hiroshige; Umegaki, Hiroyuki; Suzuki, Yusuke; Oohara-Kurotani, Shinobu; Yamaguchi, Yoko; Iguchi, Akihisa

doi:10.1007/s00213-005-0072-x

Cited by 43 publications

(24 citation statements)

References 46 publications

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“…Umegaki et al (2001) reported that injection of a D 2 receptor antagonist into HPC impaired memory performance and that the memory impairment was ameliorated by coinjection of a D 2 receptor agonist. They also found that local infusion of D 2 agonist into HPC stimulated acetylcholine release in HPC and ameliorated scopolamine-induced memory impairment (Fujishiro et al, 2005). In addition, hippocampal D 2 receptors appear to be involved in synaptic plasticity.…”

Section: Discussionmentioning

confidence: 95%

Differential Contributions of Prefrontal and Hippocampal Dopamine D₁and D₂Receptors in Human Cognitive Functions

Takahashi¹,

Kato²,

Takano³

et al. 2008

J. Neurosci.

158

117

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Section: Discussionmentioning

confidence: 95%

Differential Contributions of Prefrontal and Hippocampal Dopamine D₁and D₂Receptors in Human Cognitive Functions

Takahashi¹,

Kato²,

Takano³

et al. 2008

J. Neurosci.

158

117

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“…Yokoyama et al (1995) demonstrated widespread distribution of DA D 2 -like receptor in the hippocampus. DA D 2 receptor plays a role in hippocampal memory function especially spatial working memory (Wilkerson and Levin 1999;Hiroshige et al 2005). Earlier studies suggest that DA D 1 but not DA D 2 receptors are crucial for the DAergic control of the NMDA receptor-mediated synaptic response on a specific excitatory input to the prefrontal cortex (PFC).…”

Section: Discussionmentioning

confidence: 99%

Enhanced Dopamine D1 and D2 Receptor Gene Expression in the Hippocampus of Hypoglycaemic and Diabetic Rats

2009

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Hypoglycaemic coma and brain injury are potential complications of insulin therapy. Hippocampal neurons are particularly vulnerable to hypoglycaemic stress leading to memory impairment. In the present article, we have investigated the dopamine (DA) content, homovanillic acid (HVA)/DA turnover ratio, DA D(1) and DA D(2) receptors in the hippocampus of insulin-induced hypoglycaemic (IIH) and streptozotocin induced diabetic rats where brain functions are impaired. The DA content decreased significantly in hippocampus of diabetic, diabetic +IIH and control +IIH rats compared to control. The HVA/DA turnover ratio also increased significantly in diabetic, diabetic +IIH and control +IIH rats compared to control. Scatchard analysis using [(3)H] DA in the hippocampus showed a significant increase in DA receptors of diabetic, diabetic +IIH and control +IIH rats with decreased affinity. Gene expression studies using Real-time PCR showed an increased expression of DA D(1) and DA D(2) receptors in the hippocampus of hypoglycaemic and diabetic rats. Our results indicate that the dopaminergic system is impaired in the hippocampus of hypoglycaemic and hyperglycaemic rats impairing DA related functions of hippocampus. We observed a prominent dopaminergic functional disturbance in the hypoglycaemic condition than in hyperglycaemia compared to control. This dopaminergic dysfunction in hippocampus during hypoglycaemia and hyperglycaemia is suggested to contribute to cognitive and memory deficits. This will have clinical significance in the treatment of diabetes.

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“…Examples include GABA (Swant, Stramiello, & Wagner, 2008), glutamate (Cestari & Castellano, 1997;Mele et al, 1996), acetylcholine (Fujishiro et al, 2005), and serotonin (PradoAlcalá et al, 2003) transmitter systems, all of which decline in old age (for reviews, see Eppinger, Hämmerer, & Li, 2011;Magnusson, Brim, & Das, 2010;Rissman, De Blas, & Armstrong, 2007).…”

Section: Discussionmentioning

confidence: 99%

Dopaminergic Gene Polymorphisms Affect Long-term Forgetting in Old Age: Further Support for the Magnification Hypothesis

Papenberg

Bäckman

Nagel

et al. 2013

Journal of Cognitive Neuroscience

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Abstract■ Emerging evidence from animal studies suggests that suboptimal dopamine (DA) modulation may be associated with increased forgetting of episodic information. Extending these observations, we investigated the influence of DA-relevant genes on forgetting in samples of younger (n = 433, 20-31 years) and older (n = 690, 59-71 years) adults. The effects of single nucleotide polymorphisms of the DA D2 (DRD2) and D3 (DRD3) receptor genes as well as the DA transporter gene (DAT1; SLC6A3) were examined. Over the course of one week, older adults carrying two or three genotypes associated with higher DA signaling (i.e., higher availability of DA and DA receptors) forgot less pictorial information than older individuals carrying only one or no beneficial genotype. No such genetic effects were found in younger adults. The results are consistent with the view that genetic effects on cognition are magnified in old age. To the best of our knowledge, this is the first report to relate genotypes associated with suboptimal DA modulation to more long-term forgetting in humans. Independent replication studies in other populations are needed to confirm the observed association. ■

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Dopamine D2 receptor plays a role in memory function: implications of dopamine–acetylcholine interaction in the ventral hippocampus

Abstract: These results indicate the possible involvement of hippocampal ACh-DA interaction in mnemonic processing.

Cited by 43 publications

References 46 publications

Differential Contributions of Prefrontal and Hippocampal Dopamine D₁and D₂Receptors in Human Cognitive Functions

Differential Contributions of Prefrontal and Hippocampal Dopamine D₁and D₂Receptors in Human Cognitive Functions

Enhanced Dopamine D1 and D2 Receptor Gene Expression in the Hippocampus of Hypoglycaemic and Diabetic Rats

Dopaminergic Gene Polymorphisms Affect Long-term Forgetting in Old Age: Further Support for the Magnification Hypothesis

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Dopamine D2 receptor plays a role in memory function: implications of dopamine–acetylcholine interaction in the ventral hippocampus

Abstract: These results indicate the possible involvement of hippocampal ACh-DA interaction in mnemonic processing.

Cited by 43 publications

References 46 publications

Differential Contributions of Prefrontal and Hippocampal Dopamine D1and D2Receptors in Human Cognitive Functions

Differential Contributions of Prefrontal and Hippocampal Dopamine D1and D2Receptors in Human Cognitive Functions

Enhanced Dopamine D1 and D2 Receptor Gene Expression in the Hippocampus of Hypoglycaemic and Diabetic Rats

Dopaminergic Gene Polymorphisms Affect Long-term Forgetting in Old Age: Further Support for the Magnification Hypothesis

Contact Info

Product

Resources

About

Differential Contributions of Prefrontal and Hippocampal Dopamine D₁and D₂Receptors in Human Cognitive Functions

Differential Contributions of Prefrontal and Hippocampal Dopamine D₁and D₂Receptors in Human Cognitive Functions