Dopamine D4 receptor polymorphism and schizophrenia

Population Migration and the Variation of Dopamine D4 Receptor (DRD4) Allele Frequencies Around the Globe

“…For instance, modern human beings arrived in Asia about 60,000 years ago. We speculate that having been foragers for a (Nanko et al 1993) 1 7 162 Study 2 (Inoue et al 1993) 0 6 104 Study 3 (Ono et al 1997) 0 6 306 Study 4 (Tanaka et al 1995) 1 5 140 Japanese in the U.S. (Chang et al 1996) 0 4 102 Han Chinese…”

“…Data on the global distribution of DRD4 allele frequencies were compiled from 12 studies (Castro et al 1997;Chang et al 1996;Ebstein et al 1996;Gelernter et al 1997;Geijer et al 1997;Hong et al 1997;Inoue et al 1993;Li et al 1997;Nanko et al 1993;Ono et al 1997;Petronis et al 1992;Tanaka et al 1995). [It should be noted that most studies included both samples with psychiatric disorders and controls.…”

Dopamine D4 receptor 48-bp repeat polymorphism: no association with response to antipsychotic treatment, but association with catatonic schizophrenia

“…18,20,22,23 In contrast, Sommer et al 23 Combined genotypes as described in Table 3. Mean value of the difference with 95% confidence limits between enrolment in the study and after week 5 of treatment.…”

“…Most studies investigating schizophrenia have not been able to find significant association of the DRD4 48-bp VNTR. 5,[16][17][18][19][20][21][22][23] Most of them, however, have examined only small sample sizes. We therefore studied the population frequencies of the 48-bp repeat region in a large Caucasian population composed of schizophrenic patients, healthy subjects, and non-psychiatric patients.…”

Association of Psychosocial Factors With Dopamine Receptor D4 (Drd4), Dat Gene Polymorphism and Cardiovascular Incidence Risk

“…Spielberger's inventories were filled out by each participant individually. Genotyping of the gene polymorphism was performed in the Molecular Genetics Laboratory of the Research Institute of Internal Medicine by using the methods described in detail elsewhere [23][24][25][26]. Frequency distribution of the variable number of tandem repeat (VNTR) polymorphisms in the DRD4 and DAT genes in a population of 25-64-year-old males is shown in Table 1 and Table 2.…”