Dopamine in the Pathophysiology of Preeclampsia and Gestational Hypertension: Monoamine Oxidase (MAO) and Catechol-O-methyl Transferase (COMT) as Possible Mechanisms

Phoswa, Wendy N.

doi:10.1155/2019/3546294

Cited by 18 publications

(14 citation statements)

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“…Another hypertensive disorder of pregnancy that is similar to preeclampsia is gestational hypertension (GH). Gestational hypertension is defined as pregnancy-induced hypertension without proteinuria [ 71 , 72 ]. Both PE and GH oxidative stress are noted as the primary factors that lead to the pathogenesis and pathophysiology of each disease [ 72 ].…”

Section: Oxidative Stress In Gestational Hypertensionmentioning

confidence: 99%

“…Gestational hypertension is defined as pregnancy-induced hypertension without proteinuria [ 71 , 72 ]. Both PE and GH oxidative stress are noted as the primary factors that lead to the pathogenesis and pathophysiology of each disease [ 72 ]. A study by Kurlak et al, which investigated oxidative stress profiles in hypertensive states (PE and GH), indicated that oxidative stress profiles do not differ in hypertensive states [ 71 ].…”

Section: Oxidative Stress In Gestational Hypertensionmentioning

confidence: 99%

“…A study by Kurlak et al, which investigated oxidative stress profiles in hypertensive states (PE and GH), indicated that oxidative stress profiles do not differ in hypertensive states [ 71 ]. The only difference between PE and GH is that in PE there is proteinuria [ 72 ]. We speculate that this proteinuria occurs as a result of oxidative stress in the kidneys.…”

Section: Oxidative Stress In Gestational Hypertensionmentioning

confidence: 99%

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The Role of Oxidative Stress in Hypertensive Disorders of Pregnancy (Preeclampsia, Gestational Hypertension) and Metabolic Disorder of Pregnancy (Gestational Diabetes Mellitus)

Phoswa

Khaliq

2021

Oxidative Medicine and Cellular Longevity

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111

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Purpose of the Review.To highlight the role of oxidative stress in hypertensive disorders of pregnancy (HDP) and metabolic disorders of pregnancy (gestational diabetes mellitus). Recent Findings. In both preeclampsia (PE) and gestational hypertension (GH), oxidative stress leads to inadequate placental perfusion thus resulting in a hypoxic placenta, which generally leads to the activation of maternal systemic inflammatory response. In PE, this causes inflammation in the kidneys and leads to proteinuria. A proteinuria marker known as urinary 8-oxoGuo excretion is expressed in preeclampsia. In GDM, oxidative stress plays a role in the pathogenesis of the disease, as a result of over secretion of insulin during pregnancy. This uncontrolled secretion of insulin results in the production of lipid peroxidation factors that also mask the secretion of antioxidants. Therefore, ROS becomes abundant at cellular level and prevents the cells from transporting glucose to body tissues. Summary. There is a need for more research investigating the role of oxidative stress, especially in obstetrics-related conditions. More studies are required in order to understand the difference between the pathogenesis and pathophysiology of PE versus GH since investigations on the differences in genetic aspects of each condition are lacking. Furthermore, research to improve diagnostic procedures for GDM in pregnancy is needed.

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Section: Oxidative Stress In Gestational Hypertensionmentioning

confidence: 99%

Section: Oxidative Stress In Gestational Hypertensionmentioning

confidence: 99%

Section: Oxidative Stress In Gestational Hypertensionmentioning

confidence: 99%

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The Role of Oxidative Stress in Hypertensive Disorders of Pregnancy (Preeclampsia, Gestational Hypertension) and Metabolic Disorder of Pregnancy (Gestational Diabetes Mellitus)

Phoswa

Khaliq

2021

Oxidative Medicine and Cellular Longevity

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111

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“…Recent studies show that MAO is a major source of deleterious reactive oxygen species (ROS), regulating cardiomyocyte aging or death ( 45 , 46 ). Myocardial ROS are involved in the pathophysiology of cardiovascular diseases such as hypertension and heart failure ( 47 , 48 ), and are important markers of atrial fibrillation in patients after cardiac surgery ( 49 ). Thus, MAO inhibition therapy is protective in several settings of cardiac stresses such as pressure overload heart failure, diabetic cardiomyopathy and chronic ischemic heart disease ( 47 ).…”

Section: Discussionmentioning

confidence: 99%

Predicting All-Cause Mortality Risk in Atrial Fibrillation Patients: A Novel LASSO-Cox Model Generated From a Prospective Dataset

Chen

et al. 2021

Front. Cardiovasc. Med.

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Background: Although mortality remains high in patients with atrial fibrillation (AF), there have been limited studies exploring machine learning (ML) models on mortality risk prediction in patients with AF.Objectives: This study sought to develop an ML model that captures important variables in order to predict all-cause mortality in AF patients.Methods: In this single center prospective study, an ML-based mortality prediction model was developed and validated using a dataset of 2,012 patients who experienced AF from November 2018 to February 2020 at the First Affiliated Hospital of Shantou University Medical College. The dataset was randomly divided into a training set (70%, n = 1,223) and a validation set (30%, n = 552). A total of 122 features were collected for variable selection. Least absolute shrinkage and selection operator (LASSO) and random forest (RF) algorithms were used for variable selection. Ten ML models were developed using variables selected by LASSO or RF. The best model was selected and compared with conventional risk scores. A nomogram and user-friendly online tool were developed to facilitate the mortality predictions and management recommendations.Results: Thirteen features were selected by the LASSO regression algorithm. The LASSO-Cox model achieved an area under the curve (AUC) of 0.842 in the training dataset, and 0.854 in the validation dataset. A nomogram based on eight independent features was developed for the prediction of survival at 30, 180, and 365 days following discharge. Both the time dependent receiver operating characteristic (ROC) and decision curve analysis (DCA) showed better performances of the nomogram compared to the CHA2DS2-VASc and HAS-BLED models.Conclusions: The LASSO-Cox mortality predictive model shows potential benefits in death risk evaluation for AF patients over the 365-day period following discharge. This novel ML approach may also provide physicians with personalized management recommendations.

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“…It is the main degrading enzyme involved in the degradation of catecholamines in the cerebral cortex, which preferentially affects prefrontal cortical dopamine metabolism. [ 3 , 4 ] The gene encoding COMT is located on chromosome 22q11.2 and contains a functional polymorphism (rs4680). In the gene sequence of codon 158, a nucleotide change from guanine to adenine (G to A), resulting in substituting valine for methionine reduces the COMT enzyme activity three to four-folds.…”

Section: Introductionmentioning

confidence: 99%

Association of Val158Met polymorphism in COMT gene with attention-deficit hyperactive disorder

et al. 2020

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Background: The results of published articles on the relationship between the Val158Met polymorphism in the (Catechol-O-methyltransferase) COMT gene and the susceptibility of attention-deficit hyperactive disorder (ADHD) are controversial. We conducted an updated meta-analysis of case-control studies to assess the relationship between Val158Met polymorphism in COMT gene and ADHD susceptibility. Methods: A comprehensive literature search was conducted to identify all the case-control studies on the relationship between the COMT gene Val158Met polymorphism and ADHD susceptibility. According to the heterogeneity test results among studies evaluated with I 2 , the fixed effect model or random effect model was selected as the pooling method. Meta-regression as well as sensitive analysis were used to explore possible causes of between-study heterogeneity. The funnel plot and Harbord test were used to estimate publication bias. Results: Finally, seventeen studies that met the inclusion criteria were included. The Val158Met genotype distributions of COMT gene in controls were in Hardy–Weinberg equilibrium in all studies. In general, there was no significant association between the COMT gene Val158Met polymorphism and ADHD susceptibility in dominant, recessive, and codominant models. The recessive genetic model ( I 2 = 60.8%) showed strong heterogeneity among studies, and still no significant association was found after sensitivity analysis. Subgroup analysis stratified by ethnicity (Asian and Caucasian) also showed that there was no significant association in the above-mentioned three models. Conclusions: This updated meta-analysis indicated that the Val158Met polymorphism in the COMT gene may not be related to the risk of ADHD. Further researches are needed to confirm these results.

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Dopamine in the Pathophysiology of Preeclampsia and Gestational Hypertension: Monoamine Oxidase (MAO) and Catechol-O-methyl Transferase (COMT) as Possible Mechanisms

Cited by 18 publications

References 83 publications

The Role of Oxidative Stress in Hypertensive Disorders of Pregnancy (Preeclampsia, Gestational Hypertension) and Metabolic Disorder of Pregnancy (Gestational Diabetes Mellitus)

The Role of Oxidative Stress in Hypertensive Disorders of Pregnancy (Preeclampsia, Gestational Hypertension) and Metabolic Disorder of Pregnancy (Gestational Diabetes Mellitus)

Predicting All-Cause Mortality Risk in Atrial Fibrillation Patients: A Novel LASSO-Cox Model Generated From a Prospective Dataset

Association of Val158Met polymorphism in COMT gene with attention-deficit hyperactive disorder

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