Dopamine-modified chitosan hydrogel for spinal cord injury

Liu, Kun; Dong, Xianzhen; Wang, Yue; Wu, Xiaopei; Dai, Honglian

doi:10.1016/j.carbpol.2022.120047

Cited by 59 publications

(15 citation statements)

References 36 publications

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“…Crosslinking with citric acid produced dopamine-modified chitosan hydrogels for use in neural tissue engineering. Dopamine’s high density of crosslinking points allowed the hydrogel to have a rigid structure and significant mechanical strength through crosslinking [ 78 ]. The properties conferred by chitosan crosslinking result in frames with reduced degradability, immunogenicity, and toxicity, in addition to biocompatibility.…”

Section: Chemical Changes For Chitosan Functionalizationmentioning

confidence: 99%

Double-Network Chitosan-Based Hydrogels with Improved Mechanical, Conductive, Antimicrobial, and Antibiofouling Properties

Carpa

Farkas

Dobrotă

et al. 2023

Gels

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In recent years, the antimicrobial activity of chitosan-based hydrogels has been at the forefront of research in wound healing and the prevention of medical device contamination. Anti-infective therapy is a serious challenge given the increasing prevalence of bacterial resistance to antibiotics as well as their ability to form biofilms. Unfortunately, hydrogel resistance and biocompatibility do not always meet the demands of biomedical applications. As a result, the development of double-network hydrogels could be a solution to these issues. This review discusses the most recent techniques for creating double-network chitosan-based hydrogels with improved structural and functional properties. The applications of these hydrogels are also discussed in terms of tissue recovery after injuries, wound infection prevention, and biofouling of medical devices and surfaces for pharmaceutical and medical applications.

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Section: Chemical Changes For Chitosan Functionalizationmentioning

confidence: 99%

Double-Network Chitosan-Based Hydrogels with Improved Mechanical, Conductive, Antimicrobial, and Antibiofouling Properties

Carpa

Farkas

Dobrotă

et al. 2023

Gels

View full text Add to dashboard Cite

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“…Chitosan (CS) is a kind of natural linear polysaccharide polymer that is a kind of compound formed by the deacetylation of chitin. CS has excellent biocompatibility, low toxicity, hydrophilicity, antibacterial properties, and so on. , The antibacterial mechanism of chitosan is mainly due to its unique electrostatic attraction. CS is a positively charged polysaccharide, which interacts with the negatively charged bacterial cell wall, resulting in cavities in the cell wall leading to perforation and changes in membrane permeability, resulting in exudation of intracellular components leading to bacterial lysis. , The partial solubilization of chitosan in media may be the cause of its antibacterial properties.…”

Section: Introductionmentioning

confidence: 99%

An Antibacterial Bionic Periosteum with Angiogenesis-Neurogenesis Coupling Effect for Bone Regeneration

Zhou,

Liu,

Liu

et al. 2024

ACS Appl. Mater. Interfaces

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The periosteum, rich in neurovascular networks, bone progenitor cells, and stem cells, is vital for bone repair. Current artificial periosteal materials face challenges in mechanical strength, bacterial infection, and promoting osteogenic differentiation and angiogenesis. To address these issues, we adjusted the electrospinning ratio of poly-ε-caprolactone and chitosan and incorporated Zn doping whitlockite with polydopamine coating into a nanofiber membrane. After a series of characterizations, optimal results were achieved with a poly-ε-caprolactone: chitosan ratio of 8:1 and 5% nanoparticle content. In vitro cell experiments and in vivo calvarial defect models, the sustained release of Mg2+ and Ca2+ promoted vascularization and new bone formation, respectively, while the release of Zn2+ was conducive to antibacterial and cooperated with Mg2+ to promote neurovascularization. Consequently, this antibacterial bionic periosteum with an angiogenesis-neurogenesis coupling effect demonstrates a promising potential for bone repair applications.

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“…Chitosan is a natural polysaccharide and has attracted much interest over the past decade due to its abundant sources, excellent biocompatibility, and antibacterial properties. , This amino-rich biopolymer easily complexes and is modified with guest polymers to broaden its applications compared to starch, cellulose, glucan, and so on. − Thus, chitosan and its derivatives are good candidates for preparing high-performance biomaterials. − In particular, the chitosan-based multinetwork hydrogels have outstanding mechanical properties, physiological structures, and biological properties with advanced applications. For example, chitosan/polyacrylic acid hydrogels are tough, strong adhesives to tissues, which greatly promote the bioelectronics’ stable operation for long-term continuous imaging of diverse organs .…”

Section: Introductionmentioning

confidence: 99%

Trifunctional Microgel-Mediated Preparation and Toughening of Printable High-Performance Chitosan Hydrogels for Underwater Communications

Wang

Liu

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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Natural and biocompatible chitosan has demonstrated wide applications. However, rapidly fabricating highperformance chitosan hydrogels in one-step controllable processes is still a challenge for some advanced applications. Here, we report a trifunctional microgel-mediated photochemical (TMMP) strategy to achieve the fabrication of printable tough chitosan-based hydrogels (PTCHs) in seconds. Such microgels help the slow release of persulfate anions and their uniform dispersion in an aqueous solution of cationic chitosan. The released persulfates are available for preparing multiple networks of phenolic coupling of modified chitosan and radical polymerization of Pluronic F127 via orthogonal tris(bipyridine)ruthenium(II)-based photochemistry, respectively. Trifunctional microgels have reversible Ca 2+ -crosslinked networks that further improve the hydrogels' mechanical properties and toughness. The maximum stress and toughness increase by >20 folds compared to the chitosan and F127 hydrogels with single network structures. Moreover, these microgels enable the precursor to have a good shearing-thinning property and benefit the controllable preparation of PTCHs in a short time, as low as ∼4 s under visible light irradiation. It, therefore, is compatible with standard printing techniques to make complex structures. Strain sensors based on structured PTCHs have stable mechanical and responsive properties in the water, which are applied for realtime underwater communications (<0.4 s). It is anticipated that this one-step TMMP strategy opens new horizons for designing advanced chitosan hydrogels.

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Dopamine-modified chitosan hydrogel for spinal cord injury

Cited by 59 publications

References 36 publications

Double-Network Chitosan-Based Hydrogels with Improved Mechanical, Conductive, Antimicrobial, and Antibiofouling Properties

Double-Network Chitosan-Based Hydrogels with Improved Mechanical, Conductive, Antimicrobial, and Antibiofouling Properties

An Antibacterial Bionic Periosteum with Angiogenesis-Neurogenesis Coupling Effect for Bone Regeneration

Trifunctional Microgel-Mediated Preparation and Toughening of Printable High-Performance Chitosan Hydrogels for Underwater Communications

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