Dopamine produces vasolidation in specific regions and layers of the rabbit gastrointestinal tract

Kullmann, R.; Breull, W.; Reinsberg, Jochen; Wassermann, Karsten; Konopatzki, A.

doi:10.1016/0024-3205(83)90100-5

Cited by 41 publications

(16 citation statements)

References 14 publications

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“…Whereas some authors report an increase in splanchnic blood flow (32)(33)(34)(35)(36)(37), others report no change (38,39) or even a decrease (40 -43). These conflicting results may be attributed to dopamine's complex receptor profile, as detailed above.…”

Section: Interpretation Of Resultsmentioning

confidence: 95%

Fenoldopam—but not dopamine—selectively increases gastric mucosal oxygenation in dogs

Schwarte

Picker²,

Schindler³

et al. 2003

Critical Care Medicine

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Fenoldopam dose-dependently increased microvascular oxygenation of the gastric mucosa without changing systemic oxygen transport, i.e., this drug acted selectively on the splanchnic mucosa. The increase in gastric mucosal oxygenation was mediated by DA(1)-receptors. In contrast, dopamine markedly increased systemic oxygen transport, but did not affect microvascular oxygenation of gastric mucosa. This lacking effect on gastric mucosal oxygenation was not caused by alpha(1)-mediated vasoconstriction. The regional effects of both catecholamines could not be deduced from systemic hemodynamics and oxygenation.

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Section: Interpretation Of Resultsmentioning

confidence: 95%

Fenoldopam—but not dopamine—selectively increases gastric mucosal oxygenation in dogs

Schwarte

Picker²,

Schindler³

et al. 2003

Critical Care Medicine

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“…These discrepancies may be due to dopamine's dosedependent receptor profile, unpredictable pharmacokinetics (20), and grossly differing study settings. Although dopamine is reported to increase splanchnic perfusion under physiologic conditions (5,53), it may be less effective or even harmful under compromised circulatory conditions, for example, during sepsis (6,49,54). In addition, it remains unclear whether reported increases in splanchnic perfusion are a selective regional effect or just mirror increases in CO (13,55).…”

Section: Interpretation Of Resultsmentioning

confidence: 95%

“…To increase splanchnic tissue oxygenation, catecholamines with activity on dopaminergic DA 1 -receptors, mediating mesenteric vasodilation, have been suggested (3). Moreover, since DA 1 -receptors are densely located in the vessels of the gastrointestinal mucosa compared with other layers, dopaminergics might facilitate intramural redistribution of perfusion toward the mucosa (3)(4)(5). In this context, dopamine has been used commonly, but its effectiveness has been questioned increasingly (6 -8).…”

mentioning

confidence: 98%

Dopamine under α1-blockade, but not dopamine alone or fenoldopam, increases depressed gastric mucosal oxygenation*

Schwarte

Picker

Schindler

et al. 2004

Critical Care Medicine

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During compromised cardiocirculatory conditions, alpha1-receptor activation during dopamine infusion prevented an increase in gastric mucosal oxygenation. Furthermore, selective DA1-stimulation (by fenoldopam) was insufficient to overcome the PEEP-induced depression of microHbO2. The responses of gastric mucosal oxygenation did not parallel changes in systemic oxygen transport. These findings were independent of fluid resuscitation.

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“…Dopamine, as an enteric neurotransmitter, has been identified in mouse, guinea pig (Li et al 2004), and human (Anlauf et al 2003). It is not only released from enteric neurons, but can also be synthesized in gastrointestinal epithelial cells and can act as a paracrine modulator of ion transport (Vieira-Coelho and In the mammalian gastrointestinal system, including that of human, dopamine joins in the modulation of manifold functions, including gastrointestinal exocrine secretion (Willems et al 1985), fluid absorption (Donowitz et al 1982), intestinal motility (Marzio et al 1990;Li et al 2006), blood flow (Kullmann et al 1983), cytoprotective function (Glavin and Szabo 1990), and immunomodulation (Oberbeck et al 2006).…”

Section: Introductionmentioning

confidence: 97%

β-Adrenoceptors, but not dopamine receptors, mediate dopamine-induced ion transport in late distal colon of rats

Zhang

et al. 2008

Cell Tissue Res

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Dopamine, an important modulator in the gastrointestinal system, induces concentration-dependent transepithelial ion transport in the distal colon of the rat, as shown by a decrease in the short-circuit current, and acts in a segmentally dependent manner. However, the receptor(s) that mediates dopamine-induced ion transport is unknown. We have investigated the receptor mechanisms underlying dopamine-induced colonic ion transport by means of short-circuit current recording, real-time polymerase chain reaction, and Western blotting analysis, plus gene transfection and enzyme-linked immunosorbance assay. mRNA transcripts of adrenoceptors (alpha, beta) and dopaminergic receptors (D(1) and D(2)) were detected in the rat late distal colonic mucosa, with beta(2) displaying the highest expression. A similar result was found in human colorectal mucosa (equivalent of late distal colon in rat). Pretreatment with a beta(1)-adrenoceptor antagonist (CGP-20712A) and a beta(2)-adrenoceptor antagonist (ICI 118,551) inhibited the dopamine-induced short-circuit current response by 52.59% and 92.51%, respectively. However, neither dopamine D(1) receptor antagonist SCH-23390 nor dopamine D(2) receptor antagonist sulpiride blocked the effect of dopamine. Protein expression of both beta(1)- and beta(2)-adrenoceptors was found in the mucosa of rat distal colon and human sigmoid colon and rectum. Dopamine significantly increased intracellular cAMP levels in COS-7 cells transfected with beta(1)- or beta(2)-adrenoceptors. Thus, beta-adrenoceptors (mainly beta(2)-adrenoceptors), but not dopamine receptors, mediate dopamine-induced ion transport in the late distal colon of the rat. This extends our knowledge of the late distal colon (rats) or colorectum (human) and provides further experimental evidence that might aid the prevention, diagnosis, and clinical therapy of human colorectal diseases.

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Dopamine produces vasolidation in specific regions and layers of the rabbit gastrointestinal tract

Cited by 41 publications

References 14 publications

Fenoldopam—but not dopamine—selectively increases gastric mucosal oxygenation in dogs

Fenoldopam—but not dopamine—selectively increases gastric mucosal oxygenation in dogs

Dopamine under α1-blockade, but not dopamine alone or fenoldopam, increases depressed gastric mucosal oxygenation*

β-Adrenoceptors, but not dopamine receptors, mediate dopamine-induced ion transport in late distal colon of rats

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