Dopamine regulates the glutamatergic inner hair cell activity in guinea pigs

Oestreicher, Elmar; Arnold, W.; Ehrenberger, K.; Felix, Dominik

doi:10.1016/s0378-5955(97)00023-3

Cited by 62 publications

(48 citation statements)

References 18 publications

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“…The inhibition of NMDA, AMPA and ACPD excitatory responses by DOP agonists suggests that DOP exerts inhibitory control over both ionotropic and metabotropic types of L -Glu receptors and that one possible site for DOP action is on the postsynaptic membrane of the hair cell, the afferent fiber synapse. This is in agreement with reports describing modulatory actions of DOP, D 1 and D 2 agonists in the mammalian cochlea [14][15][16]22] .…”

Section: Discussionsupporting

confidence: 93%

“…The D 1 agonist CAPB and the D 2 agonist QUI modulated the frequency of afferent discharge in the range of 50-100 M . Sensitivity of bath-applied DOP agonists obtained in the present experiments corresponds well to results reported on the inhibitory effects of DOP agonists in the mammalian cochlea [14][15][16] . Interestingly, the dose-response curves of DOP agonists were quite similar to each other in one important respect: without stimulation, the vestibular organs demonstrated ongoing transmitter release as shown by the continuous afferent discharge.…”

Section: Discussionsupporting

confidence: 90%

“…Employing the microiontophoretic technique, evidence was obtained that DOP had a specific biological effect on afferent synaptic transmission in the cochlea of mammals [14,15] . Excitatory action of L -Glu agonists could be depressed by coadministration with D 1 and D 2 agonists in a dose-dependent manner.…”

Section: Introductionmentioning

confidence: 99%

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Dopaminergic Modulation of Afferent Synaptic Transmission in the Semicircular Canals of Frogs

Andrianov

Ryzhova²,

Tobias³

2009

Neurosignals

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Using multiunit recording of action potentials from the whole nerve with the aid of external perfusion, we investigated the effects of dopamine (DOP) agonists that are involved in modulatory actions on synaptic transmission in the isolated labyrinth preparations of frogs. The external application of DOP (0.1–1 mM), the D₁ agonist chloro-APB hydrobromide (CAPB, 50–100 μM) and the D₂ agonist quinerolane (QUI, 50–100 μM) induced a dose-dependent and reversible decline in the resting discharge frequency. In this concentration range, the potency of applied CAPB considerably exceeded that of QUI. AMPA, NMDA and ACPD responses were inhibited by the D₁ and D₂ agonists, implicating both subtypes of DOP receptors in the modulation of both ionotropic and metabotropic glutamate receptors. The inhibitory action of the DOP agonists on L-glutamate responses persisted in a high Mg²⁺ solution in conditions of selective activation of the postsynaptic membrane. The results obtained suggest that DOP may interact with both D₁ and D₂ receptor subtypes, most likely located postsynaptically on the afferent nerve fibers. This dopaminergic control mechanism may result in the reduction of the activated firing rate, thus preventing over-excitation and excitotoxic injury of the afferent dendrites after the external application of L-glutamate and excessive receptor stimulation.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

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Dopaminergic Modulation of Afferent Synaptic Transmission in the Semicircular Canals of Frogs

Andrianov

Ryzhova²,

Tobias³

2009

Neurosignals

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“…Dopamine and DA agonists inhibit AN activity (d'Aldin et al 1995a, b;Oestreicher et al 1997;Ruel et al 2001;Sun and Salvi 2001). Both GABA (Felix and Ehrenberger 1992;Malgrange et al 1997;Arnold et al 1998) and enkephalin (Burki et al 1993) similarly inhibit AN activity.…”

Section: Pharmacology Of Loc Disruption: Excitatory and Inhibitory Trmentioning

confidence: 99%

Disruption of Lateral Olivocochlear Neurons via a Dopaminergic Neurotoxin Depresses Sound-Evoked Auditory Nerve Activity

Prell

Hälsey

Hughes

et al. 2005

JARO

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We applied the dopaminergic (DA) neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to the guinea pig cochlear perilymph. Immunolabeling of lateral olivocochlear (LOC) neurons using antibodies against synaptophysin was reduced after the MPTP treatment. In contrast, labeling of the medial olivocochlear innervation remained intact. As after brainstem lesions of the lateral superior olive (LSO), the site of origin of the LOC neurons, the main effect of disrupting LOC innervation of the cochlea via MPTP was a depression of the amplitude of the compound action potential (CAP). CAP amplitude depression was similar to that produced by LSO lesions. Latency of the N1 component of the CAP, and distortion product otoacoustic emission amplitude and adaptation were unchanged by the MPTP treatment. This technique for selectively lesioning descending LOC efferents provides a new opportunity for examining LOC modulation of afferent activity and behavioral measures of perception.

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“…For example, the agonist piribedil, reported to reduce cochlear nerve responses and increase release of dopamine [d'Aldin et al, 1995a;Gaborjan et al, 1999], has similar affinities for D 2 , D 3 and D 4 receptors [Millan et al, 2002]. The agonist bromocriptine, reported to be inhibitory on cochlear neural responses and to enhance dopamine release [Halmos et al, 2002;Oestreicher et al, 1997;Sun and Salvi, 2001], has similar affinity for D 2 and D 3 though lower for D 4 receptors [Missale et al, 1998]. Sun and Salvi [2001] reported that the agonist quinpirole increases inward currents in spiral ganglion neurons, an effect that is blocked by the antagonist eticlopride.…”

Section: Introductionmentioning

confidence: 99%

The Actions of Dopamine Receptors in the Guinea Pig Cochlea

et al. 2010

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Dopamine, a major lateral olivocochlear efferent neurotransmitter, exerts both excitatory and inhibitory effects on the central nervous system depending on the receptor involved. We investigated the effects of different dopamine receptors on the cochlea by perilymphatic perfusion with D_1/5, D₂ and D₃ receptor agonists and antagonists and recording neural and hair cell responses (compound action potential – CAP; summating potential – SP) before, during and after perfusions. The D_1/5 agonist resulted in marked suppression of CAP amplitudes whilst leaving SP amplitudes unchanged, suggesting an inhibitory action of these receptors on afferent dendrites. The D_1/5 antagonist had little or no effect, suggesting that there is no influence of tonic dopamine release on these receptors. In contrast, perfusing a D₂ receptor antagonist resulted in marked suppression of CAP suggesting an excitatory action of the receptors and a strong influence of tonic dopamine release on the D₂ receptors. The D₂ agonist had little effect, implying that tonic dopamine release is maximally activating this class of dopamine receptors. D₂ antagonists resulted in reduction of SP, cochlear microphonic and distortion product otoacoustic emission amplitudes, suggesting that D₂ receptor action is not confined to afferent dendrites. Perfusion with D₃ agonists and antagonists had no effect.

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Dopamine regulates the glutamatergic inner hair cell activity in guinea pigs

Cited by 62 publications

References 18 publications

Dopaminergic Modulation of Afferent Synaptic Transmission in the Semicircular Canals of Frogs

Dopaminergic Modulation of Afferent Synaptic Transmission in the Semicircular Canals of Frogs

Disruption of Lateral Olivocochlear Neurons via a Dopaminergic Neurotoxin Depresses Sound-Evoked Auditory Nerve Activity

The Actions of Dopamine Receptors in the Guinea Pig Cochlea

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