Dopaminergic deficiency syndrome in the picture of severe brain injury in the presence of protracted depression of consciousness

Челяпина, Марина Викторовна; Sharova, E. V.; Зайцев, О.С.

doi:10.14412/2074-2711-2014-4-31-39

Cited by 4 publications

(2 citation statements)

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“…Neurochemical systems suffer from both direct damage to the anatomical structures containing cholinergic and dopaminergic neurons, and secondary edema and hypoxia [4; 5; 6; 7]. Some previous studies described clinical signs (symptoms) of post-traumatic dysfunction of each of those systems separately [8,9,10]. We also identified the EEG correlates of clinical syndromes of dopamine and choline deficiency in sTBI [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Some previous studies described clinical signs (symptoms) of post-traumatic dysfunction of each of those systems separately [8,9,10]. We also identified the EEG correlates of clinical syndromes of dopamine and choline deficiency in sTBI [8,9]. There have been no dynamic comparative studies of those clinical and EEG syndromes as manifested in traumatic disease comparatively so far.…”

Section: Introductionmentioning

confidence: 99%

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A comparative clinical and encephalographic study on manifestation of the choline and dopamine deficiency syndromes in consciousness recovery after severe traumatic brain injury

Postnikova

Sharova

Zaitsev

2019

ijmsci

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Purpose: to describe and compare the severity of clinical signs of choline and dopamine deficiency and their EEG manifestation in consciousness recovery of patients with sTBI. Material and methods: The data of dynamic and clinical EEG studies of 98 patients (68 men, 30 women) with severe traumatic brain injury were analysed. The patients were aged 13 to 57 y.o. (mean 31 ± 12 y.o). The observation period ranged from 3 weeks to 20 months after trauma. The analysis assessed the neurological status and mental activity in patients, including EEG studies with a dynamic pattern assessment. Results: the EEG pattern of dopamine deficiency syndrome featured emerging synchronised beta activity at 13-14 Hz with a significant rise in the frontal and anterior temporal regions, concurrent with a general decrease of biopotential amplitude, EEG flattening and smoothing differences between zones, as well as more or less pronounced theta rhythms. In patients with choline deficiency syndrome, alpha activity of 7–8 sec (no matter how unstable, disorganized and slow) came to be most characteristic, even in cases of deeply depressed consciousness (coma). Alpha activity was combined with an increased diffuse fast activity or polymorphic (rhythmic) groups of theta-delta waves in the EEG pattern during a general disorganization of biopotentials.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A comparative clinical and encephalographic study on manifestation of the choline and dopamine deficiency syndromes in consciousness recovery after severe traumatic brain injury

Postnikova

Sharova

Zaitsev

2019

ijmsci

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The cholinergic deficiency syndrome in patients with depressed consciousness after severe brain injury

Chelyapina

Sharova

Zaytsev

2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Тяжелая черепно-мозговая травма (ЧМТ) является одной из основных причин инвалидизации молодого на-селения [1], поэтому наиболее полная объективная оцен-ка состояния пациентов и методов их реабилитации, в том числе применение высокоэффективной фармакологиче- Цель исследования. определение клинико-электрофизиологических (ЭЭГ) признаков холинергической недостаточности в процессе восстановления сознания пациентов с тяжелой травмой головного мозга. Материал и методы. у 37 человек (24 мужчины и 13 женщин, средний возраст 32±14 лет) проведено комплексное исследование, включавшее оценку неврологического статуса, психической деятельности, а также ЭЭГ. Результаты. Выявлена совокупность неврологических симптомов в виде снижение мышечного тонуса, вегетативные нарушения в виде сухости слизистых и кожных покровов, тахикардии, гипотонии желудочно-кишечного тракта, глазодвигательные нарушения и расцениваемые как синдром недостаточности холинергической системы (Хн). данный синдром выявлялся на фоне коматозного состояния, акинетического мутизма и мутизма с пониманием речи, так и при дезинтеграции речи, амнестической дезориентировки и грубого когнитвного снижения. Этой клинической картине сопутствовали устойчивые во времени (месяцы) характерные изменения ЭЭГ: замедление и асимметрия альфа-активности, эквивалентные дипольные источники (ЭдИ) стволовой и гиппокампальной локализации, стойкое усиление внутриполушарных когеррентных связей, особенно слева. Регресс синдрома Хн сопровождается нарастанием регулярности, мощности и частоты альфа-активности (от 7-8 до 9-10 Гц), преобладанием ЭдИ в гиппокампе с появлением их в затылочных отделах полушарий, нормализацией правополушарных когеррентных связей с сохранением их патологически высоких значений слева. Ключевые слова: холинергическая система, синдром холинергической недостаточности, ээг, тяжелая черепно-мозговая травма.The cholinergic deficiency syndrome in patients with depressed consciousness after severe brain injury Objective. to determine the clinical and electrophysiological (EEG) signs of cholinergic deficiency in the process of recovery of consciousness in patients with severe brain injury. Materials and methods. thirty-seven people (24 men and 13 women, mean age 32±14 years) were studied. A comprehensive study included assessment of neurological status, mental activity, and EEG. Results and conclusion: A set of neurological symptoms, including reduced muscle tone, autonomic disorders (dry mucous membranes and skin, tachycardia, hypotension, gastrointestinal tract), eye movement disorders, that were,in accordance with the literature, characteristicof the cholinergic deficiency syndrome was found. this syndrome was detected against the background of a comatose state, akinetic mutism and mutism with understanding of speech, disintegration of speech, disorientation and amnestic decline. EEG revealed stable over time (months) characteristic changes: slowing and asymmetric alpha activity, equivalent dipole sources of hippocampal and stem localization, persistent strengthening of intra...

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Significance of Resting State Electroencephalogram for Diagnosis of Cognitive Disorders in Cardiac Surgery Patients

Тарасова

2019

SMJ

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This article reviews the issues of cognitive disorders common in cardiac surgery patients as they contribute to the structure of postoperative complications and the long-term prognosis of cardiovascular diseases. Attention is drawn to the fact that the diagnostic capabilities to assess the changes in cognitive status of cardiac surgery patients are limited; and the authors emphasize the need to search for objective and sensitive criteria for diagnosis of cognitive disorders in patients, candidates to direct myocardial revascularization. Relevance of the modern methods for brain electrical activity mapping to study neurophysiological status of patients with coronary artery disease undergoing cardiac surgery interventions is evaluated.

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Dopaminergic deficiency syndrome in the picture of severe brain injury in the presence of protracted depression of consciousness

Cited by 4 publications

References 44 publications

A comparative clinical and encephalographic study on manifestation of the choline and dopamine deficiency syndromes in consciousness recovery after severe traumatic brain injury

A comparative clinical and encephalographic study on manifestation of the choline and dopamine deficiency syndromes in consciousness recovery after severe traumatic brain injury

The cholinergic deficiency syndrome in patients with depressed consciousness after severe brain injury

Significance of Resting State Electroencephalogram for Diagnosis of Cognitive Disorders in Cardiac Surgery Patients

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