Dopaminergic modulation and rod contribution in the generation of oscillatory potentials in the tiger salamander retina

Perry, Beth; George, John

doi:10.1016/j.visres.2006.11.004

Cited by 7 publications

(8 citation statements)

References 45 publications

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“…Given that OPs are likely to be generated by the synaptic activity between the bipolar cells, the amacrine cells, and the RGCs (Wachtmeister, ), and that both D1 and D2 receptors are expressed by amacrine cells and RGCs (Mills & Massey, ; Derouiche & Asan, ; Nguyen‐Legros et al ., ; Weber et al ., ; Urschel et al ., ; Mills et al ., ; Kothmann et al ., ; Zhang et al ., ), it is possible that both inactivation of D2 receptors and over‐excitation of D1 receptors could contribute to the changes in OP amplitude of D2 −/− mice. Consistently, activating D2 receptors increases the amplitude of OPs mediated by the rod pathway (Perry & George, ), and blocking of D1 receptors or D1 receptor mutation reduces OP amplitude (Holopigian et al ., ; He et al ., ; Lavoie et al ., ). This possibility is further supported by the results that dark rearing D2 −/− mice, which could potentially block dopamine release from dopaminergic amacrine cells and D1 receptor activation, completely abolishes the effect of D2 receptor mutation on OP amplitude.…”

Section: Discussionmentioning

confidence: 85%

“…Further complicating matters, the D2 antagonist sulpiride enhances the amplitude of the b-wave mediated by rods but diminishes the b-wave mediated by cones in dark-adapted frogs (Popova & Kupenova, 2013). In the inner retina, activating D2 receptors increases the amplitude of OPs mediated by the rod pathway in the tiger salamander (Perry & George, 2007), and blocking of D2 receptors decreases the OP amplitude in the mudpuppy (Wachtmeister & Dowling, 1978;Wachtmeister, 1981Wachtmeister, , 1998.…”

Section: The Effects Of D2 Receptors On the Erg Of Adult Micementioning

confidence: 99%

“…On the other hand, dopamine D2 receptors are expressed by photoreceptors (Witkovsky et al, 1988;Ribelayga et al, 2008), RGCs (Mills et al, 2007) and amacrine cells (Derouiche & Asan, 1999;Nguyen-Legros et al, 1999;Weber et al, 2001). Activation of D2 receptors regulates gap junction couplings between rods and cones, gap junction couplings between RGCs (Mills et al, 2007;Ribelayga & Mangel, 2010), transmembrane currents in rods (Kawai et al, 2011), the amplitudes of electroretinogram (ERG) b-waves (Miranda-Anaya et al, 2002) and oscillatory potentials (OPs) (Perry & George, 2007), and the light responses of RGCs (Bodis-Wollner & Tzelepi, 1998). In addition, development and visual activity regulates the expression of dopamine receptors, the number of dopaminergic cells (Melamed et al, 1986;Klitten et al, 2008), and the storage and release of dopamine (Melamed et al, 1986;Spira & Parkinson, 1991;Shelke et al, 1997;Lorenc-Duda et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Dopamine D2 receptors preferentially regulate the development of light responses of the inner retina

Tian

Wang

2014

Eur J of Neuroscience

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Retinal light responsiveness measured via electroretinography undergoes developmental modulation and is thought to be critically regulated by both visual experience and dopamine. The primary goal of this study is to determine whether the dopamine D2 receptor regulates the visual experience-dependent functional development of the retina. Accordingly, we recorded electroretinograms from wild type mice and mice with a genetic deletion of the gene that encodes the dopamine D2 receptor raised under normal cyclic light conditions and constant darkness. Our results demonstrate that mutation of the dopamine D2 receptors preferentially increases the amplitude of the inner retinal light responses evoked by high intensity light measured as oscillatory potentials in adult mice. During postnatal development, all three major components of electroretinograms, the a-wave, b-wave and oscillatory potentials, increase with age. Comparatively, mutation of the dopamine D2 receptors preferentially reduces the age-dependent increase of b-waves evoked by low intensity light. Light deprivation from birth reduces the amplitude of b-waves and completely diminishes the increased amplitude of oscillatory potentials. Taken together, these results demonstrate that the dopamine D2 receptor plays an important role in the activity-dependent functional development of the mouse retina.

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Section: Discussionmentioning

confidence: 85%

Section: The Effects Of D2 Receptors On the Erg Of Adult Micementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dopamine D2 receptors preferentially regulate the development of light responses of the inner retina

Tian

Wang

2014

Eur J of Neuroscience

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“…Dopaminergic inhibitory neurons are likely to underlie the OPs (Wachtmeister & Dowling 1978;Wachtmeister 1981aWachtmeister , 1998Perry & George 2007). The postnatal development and maturation of dopaminergic neurons and receptors in the IPL occur late and dopaminergic neurons are not fully responsive until Day 25 in the rat (Cohen & Neff 1982;Koulen 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Most likely, the oscillatory response represents activity in neuronal inhibitory feed-back circuits initiated by amacrine cells receiving input from both rods and cones (Wachtmeister & Dowling 1978;Heynen et al 1985;Friedburg et al 2004; Lei et al 2006;Lundstr€ om et al 2007;Perry & George 2007). As the OPs respond rapidly to changes of illumination signalling back to distal retina, the OP system offers a good tool to study the neuronal adaptive system.…”

Section: Introductionmentioning

confidence: 99%

The response of the neuronal adaptive system to background illumination and readaptation to dark in the immature retina

Wang

Azazi

Eklund

et al. 2014

Acta Ophthalmologica

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ABSTRACT.Purpose: Developmental characteristics of the neuronal adaptive system of the retina, focusing on background light (BGL) adaptation and readaptation functions, were studied by measuring the oscillatory response (SOP) of the electroretinogram (ERG). Methods: Digitally filtered and conventional ERGs were simultaneously recorded. Rats aged 15 and 17 days were studied during exposure to BGLs of two mesopic intensities and during readaptation to dark. Results: Results were compared to adult rats. In 'low mesopic' BGL SOP instantly dropped significantly to about half of its dark-adapted (DA) value contrary to mature rats, in which the SOP significantly increased. In 'high mesopic' BGL SOP decreased to about 20% and 30% of DA values in immature and adult rats, respectively. The process of recovery of SOP in darkness lacked the transient enhancement immediately as BGL was turned off, characteristic of adult rats. There were no major age differences in adaptive behaviour of a-wave. In young rats, recovery of b-wave was relatively slower. Conclusions: Properties of BGL adaptation and readaptation functions of the neuronal adaptive system in baby retina differed compared to the adult one by being less forceful and more restrained. Handling of mesopic illumination and recovery in the dark was immature. Development of these functions of the neuronal adaptive system progresses postnatally and lags behind that of the photoreceptor response and seems to be delayed also compared to that of the bipolar response.

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Role of dopamine in distal retina

Popova

2014

J Comp Physiol A

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Dopamine is the most abundant catecholamine in the vertebrate retina. Despite the description of retinal dopaminergic cells three decades ago, many aspects of their function in the retina remain unclear. There is no consensus among the authors about the stimulus conditions for dopamine release (darkness, steady or flickering light) as well as about its action upon the various types of retinal cells. Many contradictory results exist concerning the dopamine effect on the gross electrical activity of the retina [reflected in electroretinogram (ERG)] and the receptors involved in its action. This review summarized current knowledge about the types of the dopaminergic neurons and receptors in the retina as well as the effects of dopamine receptor agonists and antagonists on the light responses of photoreceptors, horizontal and bipolar cells in both nonmammalian and mammalian retina. Special focus of interest concerns their effects upon the diffuse ERG as a useful tool for assessment of the overall function of the distal retina. An attempt is made to reveal some differences between the dopamine actions upon the activity of the ON versus OFF channel in the distal retina. The author has included her own results demonstrating such differences.

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Dopaminergic modulation and rod contribution in the generation of oscillatory potentials in the tiger salamander retina

Cited by 7 publications

References 45 publications

Dopamine D2 receptors preferentially regulate the development of light responses of the inner retina

Dopamine D2 receptors preferentially regulate the development of light responses of the inner retina

The response of the neuronal adaptive system to background illumination and readaptation to dark in the immature retina

Role of dopamine in distal retina

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