Doped Plasmonic Zinc Oxide Nanoparticles with Near-Infrared Absorption for Antitumor Activity

Rissi, Nathália Cristina; Comparetti, Edson José; Estevão, Bianca Martins; Mastelaro, Valmor Roberto; Zucolotto, Valtencir

doi:10.1021/acsanm.1c02197

Cited by 9 publications

(7 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The combined effect of surface plasmon resonance and superparamagnetic properties of Fe 2 O 3 provides a multimodal platform for nano thermal ablation and MRI. Rissi et al 161 observed an interesting effect of doping zinc oxide NPs with aluminum, gallium, and indium on optoelectrical properties. The doping results in enhanced absorption in the near IR region and emission range in green-yellow, orange-red, and blue-violet, depending upon the doping element.…”

Section: Raman Probes For Theranosticsmentioning

confidence: 99%

“…Only high doses (60-100 g/mL) of doped NPs revealed considerable toxicity after 24 hours of incubation. The potential of ZnO NPs for cell death in human tumors and healthy cell lines were also investigated in vitro 161 . Interestingly, ZnO NPs can stop the early leakage of medications under physiological circumstances 162 .…”

Section: Raman Probes For Theranosticsmentioning

confidence: 99%

See 1 more Smart Citation

Emergence of Raman Spectroscopy as a Probing Tool for Theranostics

Singh¹,

Yadav²,

Dhillon³

et al. 2023

Nanotheranostics

View full text Add to dashboard Cite

Although medical advances have increased our grasp of the amazing morphological, genetic, and phenotypic diversity of diseases, there are still significant technological barriers to understanding their complex and dynamic character. Specifically, the complexities of the biological systems throw a diverse set of challenges in developing efficient theranostic tools and methodologies that can probe and treat pathologies. Among several emerging theranostic techniques such as photodynamic therapy, photothermal therapy, magnetic resonance imaging, and computed tomography, Raman spectroscopy (RS) is emerging as a promising tool that is a label-free, cost-effective, and non-destructive technique. It can also provide real-time diagnostic information and can employ multimodal probes for detection and therapy. These attributes make it a perfect candidate for the analytical counterpart of the existing theranostic probes. The use of biocompatible nanomaterials for the fabrication of Raman probes provides rich structural information about the biological molecules, cells, and tissues and highly sensitive information down to single-molecule levels when integrated with advanced RS tools. This review discusses the fundamentals of Raman spectroscopic tools such as surface-enhanced Raman spectroscopy and Resonance Raman spectroscopy, their variants, and the associated theranostic applications. Besides the advantages, the current limitations, and future challenges of using RS in disease diagnosis and therapy have also been discussed.

show abstract

Section: Raman Probes For Theranosticsmentioning

confidence: 99%

Section: Raman Probes For Theranosticsmentioning

confidence: 99%

Emergence of Raman Spectroscopy as a Probing Tool for Theranostics

Singh¹,

Yadav²,

Dhillon³

et al. 2023

Nanotheranostics

View full text Add to dashboard Cite

show abstract

“…As a kind of semiconducting fluorescent material, zinc oxide (ZnO) is low-toxic and biodegradable, showing promising potential in cell imaging and drug delivery. − Eleftheriadou, Rissi, and Selim et al have tested the cytotoxicity of ZnO NPs, and the results demonstrated that ZnO NPs had little harmful effect on normal cells at suitable dose. Gwak et al have investigated the change in the physicochemical properties of ZnO nanoparticles under different pH conditions, and they claimed that the degradation of ZnO was significant in an acidic environment, while its dissolution was much slower under neutral and alkalescent conditions .…”

Section: Introductionmentioning

confidence: 99%

Sol–Gel-Derived Biodegradable Er-Doped ZnO/Polyethylene Glycol Nanoparticles for Cell Imaging

Chen

Xue

Luo

et al. 2022

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Zinc oxide nanoparticles (ZnO NPs) as promising and nontoxic fluorescent labels are currently developed for cell imaging owing to their excellent biocompatibility. However, the low intensity of the emission band and stability of ZnO NPs have restricted their further applications. In this work, 5 mol % rare-earth metal erbium (Er)-doped ZnO nanoparticles with poly(ethylene glycol) (PEG) surface modification (Er-doped ZnO/PEG NPs) are fabricated by the sol–gel method. Their fluorescence characteristics and biodegradation behavior are investigated. The results indicate that the visible photoluminescence of Er-doped ZnO/PEG NPs has been dramatically enhanced by 631.6% compared with that of bare ZnO NPs. After being stored for one month, particle size variation is less than 1 nm, and fluorescence performance can be well retained. Furthermore, the degradation and cytotoxicity results confirm the degradable and biocompatible characteristics of Er-doped ZnO/PEG NPs, thus extending their potential applications for cell imaging.

show abstract

“…Localized surface plasmon resonance (LSPR), which occurs in metal nanostructures, has attracted considerable attention from various optical-and electrical-based research fields, such as optical biosensors, color engineering, spectroscopy, metamaterials, and plasmonic optoelectronics [1][2][3][4][5]. Thus, large-scale, reproducible, high-throughput fabrication methods of wavelength-tunable LSPR substrates are in high demand not only for research but also for commercialization [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Wafer-Scale LSPR Substrate: Oblique Deposition of Gold on a Patterned Sapphire Substrate

Kim

Lee

et al. 2022

Biosensors

View full text Add to dashboard Cite

Label-free detection of biomolecules using localized surface plasmon resonance (LSPR) substrates is a highly attractive method for point-of-care (POC) testing. One of the remaining challenges to developing LSPR-based POC devices is to fabricate the LSPR substrates with large-scale, reproducible, and high-throughput. Herein, a fabrication strategy for wafer-scale LSPR substrates is demonstrated using reproducible, high-throughput techniques, such as nanoimprint lithography, wet-etching, and thin film deposition. A transparent sapphire wafer, on which SiO2-nanodot hard masks were formed via nanoimprint lithography, was anisotropically etched by a mixed solution of H2SO4 and H3PO4, resulting in a patterned sapphire substrate (PSS). An LSPR substrate was finally fabricated by oblique deposition of Au onto the PSS, which was then applied to label-free detection of the binding events of biomolecules. To the best of our knowledge, this paper is the first report on the application of the PSS used as an LSPR template by obliquely depositing a metal.

show abstract

Doped Plasmonic Zinc Oxide Nanoparticles with Near-Infrared Absorption for Antitumor Activity

Cited by 9 publications

References 71 publications

Emergence of Raman Spectroscopy as a Probing Tool for Theranostics

Emergence of Raman Spectroscopy as a Probing Tool for Theranostics

Sol–Gel-Derived Biodegradable Er-Doped ZnO/Polyethylene Glycol Nanoparticles for Cell Imaging

Wafer-Scale LSPR Substrate: Oblique Deposition of Gold on a Patterned Sapphire Substrate

Contact Info

Product

Resources

About