We report the results of Raman scattering experiments on single crystals of La2−xSrxCuO4 (La214) as a function of temperature and doping. In underdoped compounds low-energy B1g spectral weight is depleted in association with the opening of a pseudogap on regions of the Fermi surface located near (±π, 0) and (0, ±π). The magnitude of the depletion increases with decreasing doping, and in the most underdoped samples, with decreasing temperature. The spectral weight that is lost at low-energies (ω ≤ 800 cm −1 ) is transferred to the higher energy region normally occupied by multimagnon scattering. From the normal state B2g spectra we have determined the scattering rate Γ(ω,T) of qausiparticles located near the diagonal directions in k-space. In underdoped compounds, Γ(ω,T) is suppressed at low temperatures for energies less than Eg(x) ≃ 800 cm −1 . The doping dependence of both the two-magnon scattering and the scattering rate suppression suggest that the pseudogap is characterized by an energy scale Eg ∼ J, where J is the antiferromagnetic superexchange energy. Comparison with the results from other techniques provides a consistent picture of the pseudogap in La214.