Doppler Sonographic Analysis of Synovial Vascularization in a Patient With Rheumatoid Arthritis Treated With Leukocyt Apheresis

Kanno, Yukiko; Kobayashi, Hiroko; Suzuki, Eiji; Iwadate, Haruyo; Sasajima, Tomomi; Watanabe, Hiroshi; Ohira, Hiromasa

doi:10.5387/fms.54.73

Cited by 1 publication

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Positive correlations have also been reported between the clinical disease activity of RA and PDUS findings in patients receiving anti-TNF-α therapy (7)(8)(9). However, there has been no study, to our knowledge, to assess US findings in patients with RA receiving LCAP except for one case report (22). We evaluated therapeutic effects of LCAP in six patients (seven cases) and showed that LCAP significantly decreased the total PD score and the number of PD ≥ 2 joints concomitantly with the decrease of DAS28-ESR, but LCAP did not decrease the total GS score.…”

Section: Discussionmentioning

confidence: 92%

Ultrasound Evaluation of the Effects of Leukocytapheresis on Rheumatoid Arthritis

Takeuchi

Maeda²,

Kimura

et al. 2013

Ther Apher Dial

View full text Add to dashboard Cite

Leukocytapheresis (LCAP) is effective in treating rheumatoid arthritis (RA). Ultrasound (US) examination of joints is useful for evaluating disease activity and therapeutic effects in RA, but the clinical assessment of LCAP therapy with US has been little reported. We investigated the usefulness of US for evaluating the effects of LCAP in patients with RA. US examination was performed in six patients (total of seven cases) who underwent LCAP. Twenty-eight joints (bilateral shoulders, elbows, wrists, 1st to 5th metacarpophalangeal joints, 1st to 5th proximal interphalangeal joints, and knee joints) were evaluated by a systematic multiplanar grey-scale and power Doppler (PD) examination. Disease activity of RA was evaluated using the 28-joint Disease Activity Score with erythrocyte sedimentation rate (DAS28-ESR). Moderate or good responses to LCAP based on the DAS28-ESR were observed in four of the seven cases although C-reactive protein (CRP) and ESR did not decrease. LCAP significantly reduced the mean total PD score 17.3 ± 11.6 to 13.0 ± 10.5 (P = 0.0469). The total PD score decreased in six of the seven cases, and the number of joints with PD score ≥ 2 decreased in five of the seven cases. The rate of decrease in the number of joints with PD score ≥ 2 correlated strongly with the DAS28-ESR and its components, especially swollen joint counts and evaluator's global assessment, but not with the rate of decrease in CRP and ESR. US imaging of joints may be useful for evaluating the therapeutic effects of LCAP on RA compared to other inflammatory parameters.

show abstract