Doppler sonography evaluation of superior mesenteric artery flow to assess Crohn's disease activity: correlation with clinical evaluation, Crohn's disease activity index, and alpha 1-antitrypsin clearance in feces.

Oostayen, Jacques A. van; Wasser, Martin; Hogezand, R. A. van; Griffioen, G.; Biemond, I.; Lamers, C. B. H. W.; Roos, A. de

doi:10.2214/ajr.168.2.9016220

Cited by 68 publications

(27 citation statements)

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“…Similar results, with higher values of flow volume or lower resistance index, were recorded in different studies (9)(10)(11). In several studies (11,17,18) al found no difference in flow volume between inactive and control group, although it was found between control and active group. They emphasize the "gray zone" of flow volume in the superior mesenteric artery between 450 and 600 mL/min, where an overlap can occur between the control group, as well as mildly active Crohn's disease patients, and inactive Crohn's disease patients, which is similar to the findings of our study.…”

Section: Discussionsupporting

confidence: 80%

Assessment of Crohn’s Disease Activity by Doppler Ultrasound of Superior Mesenteric Artery and Mural Arteries in Thickened Bowel Wall: Cross-sectional Study

Sjekavica

Barbarić-Babić²,

Krznarić³

et al. 2007

Croat Med J

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Aim To define sensitive and reliable Doppler parameters for measurements in the superior mesenteric artery and mural arteries of affected bowel loops used in the assessment of Crohn's disease activity. MethodsWe performed cross-sectional study at a tertiary care setting in Zagreb, Croatia, between January 2001 and March 2005. We measured arterial flow in the superior mesenteric artery and affected bowel wall in 138 patients with Crohn's disease (74 with active, 64 with inactive disease) and 67 healthy volunteers. The disease activity was determined by the clinical examination, Crohn's disease activity index, and standard laboratory tests. Superior mesenteric artery color and pulsed Doppler parameters were peak systolic velocity, end-diastolic velocity, resistance index, mean velocity flow, cross-sectional area, and flow volume. When gut mural vessels were identified, we performed spectral analysis of mural arteries by pulsed Doppler, with a measurement of resistance index.

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Section: Discussionsupporting

confidence: 80%

Assessment of Crohn’s Disease Activity by Doppler Ultrasound of Superior Mesenteric Artery and Mural Arteries in Thickened Bowel Wall: Cross-sectional Study

Sjekavica

Barbarić-Babić²,

Krznarić³

et al. 2007

Croat Med J

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“…Flow measurements of the superior and inferior mesenteric arteries by Doppler ultrasound have been reported as an additional tool to measure disease activity in patients with Crohn's disease [25][26][27]. This method is complicated by angle dependence of the Doppler shift, high deviations of flow measurements and a high interequipment variability [28].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Criteria for the Activity of Crohn’s Disease by Power Doppler Sonography

Neye

Voderholzer

Rickes

et al. 2004

Dig Dis

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Background/Aim: In recent years, power Doppler sonography has been proposed as a method to assess disease activity in patients with Crohn’s disease. The aim of this prospective study was to evaluate diagnostic criteria for power Doppler sonography by blinded comparison with ileocolonoscopy. Methods: Twenty-two patients with confirmed Crohn’s disease were prospectively investigated with B-mode and power Doppler sonography (HDI 5000, Philips Ultrasound) as well as ileocolonoscopy. Sonography was performed within 3 days before endoscopy. All procedures were performed by experienced examiners who were blinded to the clinical data and other results. Defined ultrasound parameters (bowel wall thickness, vascularization pattern) were used to determine a sonographic score of the activity. The degree of activity was scored from 1 (none) to 4 (high) by both ultrasound and ileocolonoscopy (pattern, extent of typical lesions). For each patient all segments of the colon and the terminal ileum were evaluated by both ultrasound and endoscopy. The weighted ĸ test was used (StatXact software) for statistical analysis. Results: In total, 126 bowel segments were evaluated by both ultrasound and endoscopy. The study showed a high concordance of power Doppler sonography and ileocolonoscopy (weighted ĸ by region: sigmoid colon: 0.81; transverse colon: 0.78; ascending colon: 0.75; cecum: 0.84; terminal ileum: 0.82). Highest concordance was found in the descending colon (weighted ĸ: 0.91; 95% CI: 0.83–0.98). Conclusions: Combination of B-mode and power Doppler sonography has a high accuracy in the determination of disease activity in Crohn’s disease when compared to ileocolonoscopy. The diagnostic criteria established in this study can be useful for the evaluation of inflammatory bowel diseases by ultrasound.

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“…Mittels Duplexsonographie konnte in der Vergangenheit bereits signifikant höhere Flüsse und niedrigere Strö-mungswiderstände in A. mesenterica superior bei Patienten mit M. Crohn im Vergleich zu Kontrollen nachgewiesen werden [50,51,52]. Eine Differenzierung der Krankheitsaktivität ist aufgrund der gemessenen Flussraten möglich, allerdings besteht eine große Überschnei-dung der Flussgeschwindigkeiten bei aktiver Erkrankung und in Remission, sodass der Wert dieser Technik in der Evaluation der Krankheitsaktivität im klinischen Alltag fraglich erscheint (Abb.…”

Section: Arterielle Flussgeschwindigkeitunclassified

Labor, Endoskopie und neue Bildgebung

Herfarth¹

2002

Der Internist

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Diagnose Wahrscheinlich Möglich Unwahrscheinlich Colitis ulcerosa 43% 26% 31% M. Crohn 41% 27% 32% Unauffällig 8% 2% 90% Nicht spezifisch 12% 18% 70% 24 histologische Präparate von Patienten mit klinisch gesicherten M. Crohn wurden 10 Pathologen geblindet vorgelegt. Die Schnitte sollten in die Diagnosegruppen Colitis ulcerosa, M. Crohn, unauffällig und nicht spezifische Entzündung nach Wahrscheinlichkeiten eingeordnet werden. (Nach [82]) M. Crohn (n=43) Colitis ulcerosa (n=37) Rezidiv Kein Rezidiv Rezidiv Kein Rezidiv Fäkales 122 (98-229)* 42 (31-49) 123 (79-353)* 29 (20-44) Calprotectin [mg/l] BSG [mm/h]

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Doppler sonography evaluation of superior mesenteric artery flow to assess Crohn's disease activity: correlation with clinical evaluation, Crohn's disease activity index, and alpha 1-antitrypsin clearance in feces.

Cited by 68 publications

References 0 publications

Assessment of Crohn’s Disease Activity by Doppler Ultrasound of Superior Mesenteric Artery and Mural Arteries in Thickened Bowel Wall: Cross-sectional Study

Assessment of Crohn’s Disease Activity by Doppler Ultrasound of Superior Mesenteric Artery and Mural Arteries in Thickened Bowel Wall: Cross-sectional Study

Evaluation of Criteria for the Activity of Crohn’s Disease by Power Doppler Sonography

Labor, Endoskopie und neue Bildgebung

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