Doppler ultrasonography: A non‐invasive method used to diagnose and follow up patients with chronic hepatitis C

Franco, Karen Margarete Vieira da Silva; Vieira, Waldonio Brito; Dias, Ápio Ricardo Nazareth; Falcão, Aline Semblano Carreira; Falcão, Luiz Fábio Magno; Quaresma, Juarez Antônio Simões

doi:10.1111/jgh.14793

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…Franco da Silva, W. B.Vieira with colleagues, demonstrated the connection between transient elastography and speed of blood flow and spleen velocity index in liver vessels in patients with chronic hepatitis C. Thus, the average values of these indices were differed between the groups with absent or minimum (F0/FІ) and significant (≥ FII) fibrosis. As a result of the study, there was association between a monophase and two-phase spectrum of hepatic veins and stratification of hepatic fibrosis [1].…”

Section: Indicatormentioning

confidence: 82%

Role of biochemical and hemodynamic indicators in assessing the progression of liver fibrosis of various origins

et al. 2019

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Objective — to determine the peculiarities of biochemical and hemodynamic indices in patients with chronic HCV and NAFLD, their interrelations with the liver elastography data.Materials and methods. 195 patients, among whom there were 94 (48.2 %) patients with chronic HCV and 101 (51.8 %) patients with NAFLD. Determined content alanine aminotransferase, aspartate aminotransferase, total bilirubin, alkaline phosphatase, and gamma-glutamyl transpeptidase, hydroxyprolins, hexosamines orosomucoid, medium molecular peptides, bile acids and lipoproteins. The transient elastography of liver was carried out in the Shear Wave Elastography (SWE) on the Soneus P7 scanner (Ukraine). The Dopplerography was used to assess the hepatic and splenic arteries, hepatic and splenic veins. In each vessel the volume velocity of the blood flow, the average linear velocity of blood flow, vessels diameter, perfusion index and resistance index were measured.Results. The analysis of liver fibrosis indicators showed a tendency to activation of collagen synthesis, which was testified by an increase of protein-bound hydroxyproline content in patients. The level of connective tissue decay products (free hydroxyproline) had a tendency to decrease in patients with chronic HCV (p < 0.05). The obtained data and the established correlation in the group of patients with chronic HCV between protein-bound hydroxyproline level with hepatic stiffness according to SWE data in kPa (r = 0,44, p < 0.05). Median values of Young’s module were higher in patients with chronic HCV (p < 0.05). Positive correlation with Young’s module (r = 0.65, p < 0.05) is established in chronic HCV patients. The patients with chronic HCV have established a positive correlation between Young's module (Е) and Vmean in the splenic artery (r = 0.59, p < 0.05). A positive correlation between the concentration of MMP and Vmean in the hepatic artery (r = 0.54, p < 0.05) has been identified in the group of patients with NAFLD.Conclusions. According to the biochemical study of blood, the indices of the and cholestatic syndromes were reliably higher in patients with viral disease factor than in patients with NAFLD (p < 0.05). In the same category of patients, lower indicators of protein-syntesized liver function were observed (p < 0.05). In patients with chronic HCV and NAFLD, according to Dopplerography data, the diameters of hepatic and splenic veins were increased while decreasing the linear velocity of blood flow (p < 0.05).

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Section: Indicatormentioning

confidence: 82%

Role of biochemical and hemodynamic indicators in assessing the progression of liver fibrosis of various origins

et al. 2019

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“…These data are worrying, as it is of fundamental importance to determine the degree of fibrosis so that the patient can receive the suitable therapeutic measures and the most appropriate follow-up for their clinical condition. It is known that, even today, the gold standard for this determination is liver biopsy; and despite Liver transient elastography be an efficient non-invasive technique, have a high cost and is less available in public health centres (Franco et al, 2019;Fahmy et al, 2011;Mello et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Liver Fibrosis in Individuals with Hepatitis C Virus Genotype 1B from Brazilian Eastern Amazon

Silva¹,

Dias²,

Quaresma³

et al. 2023

Preprint

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IHepatitis C virus (HCV) has a high genetic diversity, with seven genotypes with 86 subtypes. This genetic variability confers persistence in the infection and escape of the immune system with evolution to cirrhosis and cancer. Environmental factors can contribute to different disease progression, being essential to assess the viral genotype in the infection and discuss the environmental particularities of Eastern Amazon, and the frequencies of Liver fibrosis between different HCV genotypes in patients living in a region of the Brazilian Eastern Brazilian Amazon. Consists in an observational cross-sectional study. Sociodemographic and clinical data of 76 individuals diagnosed with Hepatitis C between 2019 and 2020 in public health services were selected. Data collected was tabulated in Microsoft Excel 2010TM spreadsheets and analysed in GraphPad Prism 5.0TM. Liver fibrosis was associated with genetic subtypes. Subtype 1b was predominant (42.1%), followed by 1a (13%) and 3a (1.3%). 69.7% of participants had chronic hepatitis, with mild fibrosis (F1/F2) being the most prevalent (38.1%). Severe fibrosis was detected in 75% of individuals infected with the subtype 1b, that is associated with more severe disease. We suggest further studies, to assess other communities in the region, as well as the monitoring of these patients with Liver Elastography to determine the disease evolution and its better management.

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“…The disorder can be self-limiting or lead to fibrosis(scarring), cirrhosis, or liver cancer. [1] Hepatitis C infection, chronic liver damage, chronic active hepatitis, cirrhosis, and primay liver cancer are all major causes of morbidity and mortality in the human population. [2]Over the course of a 20year period, 69 percent of persons with hepatitis C will develop cirrhosis, and 1% -5% may develop hepatocellular carcinoma (HCC).…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Evaluation of Liver in Patients Who Had History of Hepatitis C

2021

JHMN

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Background: Hepatitis is an infection of liver. The disorder can be self-limiting or lead to fibrosis(scarring), cirrhosis, or liver cancer. Both acute infection and chronic sequelae, such as hepatitis C, cause significance morbidity and mortality in the hum of population. Hepatitis can be very high in general population. Our study evaluate the liver parenchyma in patients with history of Hepatitis C and provide descriptive to prevent future liver pathologies.The primary goal of our research is to delay or perhaps stop the progression of liver fibrosis, as well as to prevent liver disease.Grey scale ultrasonography has been reported to detect Ultrasonographic features of chronic disease resulting in decreased liver function and ultimately, liver failure and to help the patients with cured hepatitis C to check out the parenchymal damage and to give healthy lifestyle. Objective: To evaluate the ultrasonographic features of the liver in the patients who had history of hepatitis C. Study design: ur study design was retro prospective. Material and method:The retro prospective study was conducted in which data of 56 patients were taken. The data was collected from the radiology department of al-Razi health care and Jinnah hospital. After informed consent, data was collected through ultrasound machine. Out of 56 patients 27 were females and 29 were males. study duration was 4 months. Inclusion criteria includes patients with history of liver hepatitis C. Exclusion criteria was patients with other causes of liver disease, primary biliary cirrhosis, metabolic liver disease and liver transplant recipients except hepatitis C. Result: 56 patients were included in our study out of which 27 were females and 29 were males. The ultrasonographic findings of the patients having liver hepatitis C shows the cirrhosis in 44.6%, change in liver

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Doppler ultrasonography: A non‐invasive method used to diagnose and follow up patients with chronic hepatitis C

Cited by 3 publications

References 23 publications

Role of biochemical and hemodynamic indicators in assessing the progression of liver fibrosis of various origins

Role of biochemical and hemodynamic indicators in assessing the progression of liver fibrosis of various origins

Liver Fibrosis in Individuals with Hepatitis C Virus Genotype 1B from Brazilian Eastern Amazon

Ultrasound Evaluation of Liver in Patients Who Had History of Hepatitis C

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