Doppler Ultrasonography of Malignant Melanomas of the Uvea

Guthoff, Rudolf; Berger, R. W.; Winkler, Peter; Helmke, K.; Chumbley, L.

doi:10.1001/archopht.1991.01080040105038

Cited by 44 publications

(6 citation statements)

References 10 publications

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“…We will discuss the role of CDUS in this respect. [18][19][20] From December 1990 through March 1993, we examined 173 patients with MUM, 13 with metastases, 24 with choroidal hemangioma, and 36 with pseudotumor (including granulomas and hematomas, especially in cases of hemorrhagic agerelated macular degeneration) using sonography (both B and standardized A modes and CDUS) and fluorescein angiography. CDUS contributes to the diagnosis of intra-ocular tumors and followup after conservative treatment.…”

Section: Effect Of Intra-ocular Tumors and Massesmentioning

confidence: 99%

Color doppler imaging of orbital vessels: Personal experience and literature review

Tranquart¹,

Bergès

Koskas

et al. 2003

J of Clinical Ultrasound

107

106

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Many Doppler imaging studies have been performed in recent years in a large number of ocular disorders because of improvements in the Doppler equipment used for detecting and measuring the low blood-flow velocities that are a requisite for the quantitative evaluation of blood flow in the orbital vessels. The ophthalmic artery, central retinal artery and vein, posterior ciliary arteries, and the superior ophthalmic vein can be easily identified using color Doppler sonography. The changes in local blood flow in these vessels assessed by spectral analysis pulsed Doppler sonography have been used to characterize and to obtain new insights into different nontumoral vascular disorders including carotid artery stenosis, central retinal vein occlusion, giant cell arteritis, glaucoma, diabetes, fistulas, and tumoral processes of the eye and orbit. Our experience has confirmed the important role of Doppler sonography in the assessment of subclinical changes in the vascular bed, in the understanding of different processes, for following up after specific treatments, and for determining the long-term prognosis of these various conditions.

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Section: Effect Of Intra-ocular Tumors and Massesmentioning

confidence: 99%

Color doppler imaging of orbital vessels: Personal experience and literature review

Tranquart¹,

Bergès

Koskas

et al. 2003

J of Clinical Ultrasound

107

106

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“…Gutthof et al concluded that colour Doppler allows a rapid overview of tumour vasculature and facilitates the study of individual vessels 11. Wolff-Kormann et al reported a decrease in peak systolic frequency in choroidal melanomas within the tumour and in the tumour base after episcleral brachytherapy 12.…”

Section: Discussionmentioning

confidence: 99%

Ocular arterial blood flow of choroidal melanoma eyes before and after stereotactic radiotherapy using Leksell gamma knife: 2 year follow up

Vécsei

Kircher²,

Nagel³

et al. 1999

British Journal of Ophthalmology

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Aims-To evaluate the eVect of high dose stereotactic radiotherapy on the ocular blood flow of patients with uveal melanoma. Methods-Colour Doppler imaging (CDI) was used to measure blood flow velocity and vascular resistance in the ophthalmic, short posterior, and central retinal arteries of nine patients suVering from uveal melanoma. The measurements were taken before, 6 months, 1 year, and 2 years after stereotactic radiotherapy. Irradiation was performed with the Leksell gamma knife with the 59 (41-66.5) Gy total marginal dose divided in two equal fractions. CDI results were compared with age and sex matched healthy control eyes. Results-At each time of measurement, blood flow velocity in the central retinal artery of the aVected eyes was significantly reduced whereas vascular resistance was only increased at the 2 year follow up. Blood flow velocity and vascular resistance in the short posterior arteries of melanoma eyes were also only significantly altered at the 2 year follow up. Blood flow velocity and vascular resistance in the ophthalmic artery of melanoma eyes were not changed at all follow ups. Conclusions-In the melanoma eyes, blood flow velocity in the central retinal artery is reduced. High dose stereotactic radiotherapy with the Leksell gamma knife and a 59 (41-66.5) Gy total marginal dose in two fractions leads to a significant reduction of blood flow and a significant increase in resistance variables in the small ocular arteries within 2 years. (Br J Ophthalmol 1999;83:1324-1328 The colour Doppler sonography simultaneously produces a two dimensional grey scale B-image and a colour coded image of the blood flow recorded by a pulsed Doppler.1 2 This emitted impulse is reflected from the moving particles and may be examined according to its phase and frequency shift variances. The imaging subsequently describes a colour coded wave form (vessel) in the B-image based on the time cycle. The monitor shows blood flow areas as colour pixels while the simultaneously observed B-mode indicates the same area as an anatomical image.High resolution and computerised technologies 3 have been developed to detect even small vessels 4 (for example, the central retinal artery) and to determine the circulatory direction, blood flow velocity (maximum, median, and minimum) 2 and resistance indices (RI, Pourcelot, 5 pulsatility index, PI 6 ). Colour Doppler assessment of the normal ocular blood flow has been reported by several authors. 7-9EVective vasculature is essential for tumour growth. Many authors used the colour Doppler to measure tumour blood flow velocity in malignant melanomas of the uvea and to describe frequency shifts after therapy. 10-12We doubted the reliability and repeatability of the remeasurements because of tumour vessel direction, size, and the definition of an exact location over a period of time. We were interested in how far gamma knife radiosurgery would influence blood flow in the normal vasculature; this has not been reported before.Uveal melanoma is the most common primary ocular mal...

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“…Evidence for increased blood flow in uveal tumours has been provided by A‐ and B‐mode ultrasound, fluorescein angiography (FA) and indocyanine green angiography (Edwards et al. 1969; Hayreh 1970; Guthoff et al. 1991, 1992; Folberg et al.…”

Section: Introductionmentioning

confidence: 99%

Choroidal perfusion in eyes with untreated choroidal melanoma

Resch

Garhöfer

Schmetterer

et al. 2008

Acta Ophthalmologica

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. Purpose: Previous studies indicate that ocular blood flow is altered in eyes with choroidal melanoma. In the present study pulsatile ocular blood flow (POBF) was assessed to investigate whether there exists a correlation between tumour size and ocular blood flow parameters. Methods: Twenty‐two patients with unilateral untreated choroidal melanoma were studied using two measurement techniques: POBF was measured with a pneumotonometer and local foveal fundus pulsation amplitude (FPA) by laser interferometry, and results were correlated. Tumour volume was calculated using the ellipsoidal solid model and was correlated to POBF and FPA. Results: Levels of POBF and FPAs tended to be higher in tumour eyes compared with unaffected eyes, but the differences did not reach the level of significance. Both methods showed a high degree of correlation in unaffected eyes. In tumour eyes the correlation was slightly less pronounced. There was no correlation between tumour and POBF or FPA. Conclusions: Our results do not indicate choroidal hyperperfusion in patients with choroidal melanoma. The clinical usefulness of measuring POBF in tumour patients may be limited.

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Doppler Ultrasonography of Malignant Melanomas of the Uvea

Cited by 44 publications

References 10 publications

Color doppler imaging of orbital vessels: Personal experience and literature review

Color doppler imaging of orbital vessels: Personal experience and literature review

Ocular arterial blood flow of choroidal melanoma eyes before and after stereotactic radiotherapy using Leksell gamma knife: 2 year follow up

Choroidal perfusion in eyes with untreated choroidal melanoma

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