Doppler ultrasound imaging techniques for assessment of synovial inflammation

The purpose of this review was to summarize the current knowledge on the utilization of magnetic resonance imaging (MRI) and ultrasound (US) for assessing arthropathy in children and adolescents with haemophilia and to recognize the limitations of each imaging modality and pitfalls in the diagnosis of soft tissue and osteochondral abnormalities. Awareness of MRI and US limitations and pitfalls in the assessment of joints in persons with haemophilia is essential for accurate diagnosis and optimal management of haemophilic arthropathy.

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“…When combined with colour Doppler, US can detect the vascular synovium in contrast to the avascular haemosiderin (Fig. ) .…”

Section: Limitations Of Mri and Sources For Pitfallsmentioning

confidence: 99%

Imaging of haemophilic arthropathy in growing joints: pitfalls in ultrasound and MRI

et al. 2017

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“…In clinical practice, it is advisable to follow the EULAR guidelines for MSUS evaluation in GS and PD [55], to be familiarized with Doppler techniques [56,102], and with actual scoring systems and composites instruments for disease activity assessment [103].…”

Section: Number Of Monitored Joints Type Of Joints and Msus Scoringmentioning

confidence: 99%

Concepts in monitoring the treatment in rheumatoid arthritis â€“ the role of musculoskeletal ultrasound. Part I: synovitis.

Micu¹,

Fodor

2015

Med Ultrason

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Rheumatoid arthritis (RA) is an incurable chronic inflammatory disease associated with significant functional impairment and disability, linked to inflammatory and structural articular and peri-articular damage. Structural damage occurs rapidly in RA if inflammation is not efficiently suppressed. Identification of patients with high risk to develop RA followed by an early application of efficient medications and standard 'treat to target' recommendations allow a better management aiming remission. Over the last 15 years musculoskeletal ultrasound (MSUS) has proved to detect subclinical inflammatory lesions; thus, targeting therapy to imaging delivered information may provide superior outcomes and a more rapid response to therapy detection in comparison with clinical examination alone. This review provides an insight into the importance of MSUS in quantifying disease activity and monitoring of therapies in RA patients.

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“…However, the high cost and controlled access can limit the widespread use of MRI for general clinical screening and diagnosis. Ultrasound (US) with Doppler function provides high resolution anatomic imaging and high sensitivity in identifying abnormal blood flow 8 , 9 , and has shown capability to distinguish between active and inactive synovitis 10 , 11 . Color Doppler US, however, is more sensitive to the fast blood flow in relatively large vessels.…”

Section: Introductionmentioning

confidence: 99%

A Functional Study of Human Inflammatory Arthritis Using Photoacoustic Imaging

Cao

et al. 2017

Sci Rep

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By using our dual-modality system enabling simultaneous real-time ultrasound (US) and photoacoustic (PA) imaging of human peripheral joints, we explored the potential contribution of PA imaging modality to rheumatology clinic. By performing PA imaging at a single laser wavelength, the spatially distributed hemoglobin content reflecting the hyperemia in synovial tissue in metacarpophalangeal (MCP) joints of 16 patients were imaged, and compared to the results from 16 healthy controls. In addition, by performing PA imaging at two laser wavelengths, the spatially distributed hemoglobin oxygenation reflecting the hypoxia in inflammatory joints of 10 patients were imaged, and compared to the results from 10 healthy controls. The statistical analyses of the PA imaging results demonstrated significant differences (p < 0.001) in quantified hemoglobin content and oxygenation between the unequivocally arthritic joints and the normal joints. Increased hyperemia and increased hypoxia, two important physiological biomarkers of synovitis reflecting the increased metabolic demand and the relatively inadequate oxygen delivery in affected synovium, can both be objectively and non-invasively evaluated by PA imaging. The proposed dual-modality system has the potential of providing additional diagnostic information over the traditional US imaging approaches and introducing novel imaging biomarkers for diagnosis and treatment evaluation of inflammatory arthritis.

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Doppler ultrasound imaging techniques for assessment of synovial inflammation

Cited by 10 publications

References 47 publications

Imaging of haemophilic arthropathy in growing joints: pitfalls in ultrasound and MRI

Imaging of haemophilic arthropathy in growing joints: pitfalls in ultrasound and MRI

Concepts in monitoring the treatment in rheumatoid arthritis â€“ the role of musculoskeletal ultrasound. Part I: synovitis.

A Functional Study of Human Inflammatory Arthritis Using Photoacoustic Imaging

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