Dorsal hippocampal dopamine receptors are involved in mediating ethanol state-dependent memory

Original article Involvement of D 2 /D 2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate

“…Other studies have demonstrated that the immediate post-training blockade of D 1 and D 2 receptors located within the NAc impairs the performance of spatial learning tasks [52]. Based on some other reports, the intra-dorsal hippocampal [62] and peripheral [2,15] administration of the antagonists impair the one-trial passive avoidance and spatial or non-spatial memories in mice, respectively. However, other investigations indicate that pre-test single administration of SCH 23390 or sulpiride causes no significant change in the step-down latency [56].…”

Nicotine improves ethanol-induced memory impairment: The role of dorsal hippocampal NMDA receptors

“…Since ethanol and nicotine have the opposite effects on cognitive functions (Dawson 2000), the interaction between the two drugs is complex and not fully understood yet. For instance, learning and memory can be impaired by acute ethanol exposure (Givens et al 2000;Rezayof et al 2007). Subsequent research confirmed that the hippocampus is critically involved in ethanol-induced memory dysfunction (White et al 2000).…”

Alterations in the hippocampal phosphorylated CREB expression in drug state-dependent learning

“…Duka et al [42] and Nakagawa and Iwasaki [43] reported that ethanol-induced amnesia can be reversed by the administration of the same dose of drug in human and laboratory animals. Previous findings in our laboratory have also indicated that different neurotransmitter systems such as dorsal hippocampal glutamatergic, nitric oxide and dopaminergic systems contribute to ethanol-induced STD [44][45][46]. Signaling pathways triggered with these neurotransmitter systems play an important role in mediating CREBdependent gene expression in neurons [47][48][49].…”