Dorsal hippocampal <i>N</i>‐methyl‐<scp>d</scp>‐aspartate glutamatergic and δ‐opioidergic systems modulate anxiety behaviors in rats in a noninteractive manner

Solati, Jalal

doi:10.1016/j.kjms.2011.06.011

Cited by 17 publications

(10 citation statements)

References 37 publications

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“…Our results are in agreement with the previous investigation showing that NMDA agonist releases behavioural and anxiolytic-like behaviours indicating the role of NMDA receptors in modulation of anxiety-related behaviours [26,73]. Moreover, there is also an investigation showing that the activation of NMDA receptor induces anxiogenic-like effects in EPM and social interaction tasks [21].…”

Section: Effects Of Intra-nac Shell Nmda Administration On Anxiolyticsupporting

confidence: 93%

“…With respect to the preferential agonists, at least three subtypes have been identified for glutamate, including N-methyl-D-aspartate (NMDA), AMPA and kainate [57]. Investigations have revealed that the NMDA receptor plays a critical part in regulation of learning, memory formation (possibly through long-term potentiation and depression) [9,38] and anxiety-related behaviours [26,46,63,73,78]. A plethora of anatomical experiments have demonstrated that there are close relationships between NAc glutamatergic and dopaminergic systems [66,67].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Original article Involvement of D 2 /D 2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate

Razavi¹,

Haeri-Rohani²,

Eidi³

et al. 2014

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Section: Effects Of Intra-nac Shell Nmda Administration On Anxiolyticsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Original article Involvement of D 2 /D 2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate

Razavi¹,

Haeri-Rohani²,

Eidi³

et al. 2014

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“…Conversely, we also showed that long-term memantine administration at doses of 5, 10, or 20 mg/kg leads to an anxiogenic phenotype that is manifested by decreased time spent in the light compartment (light–dark box) and reduced time spent in open arms (elevated plus-maze). Interestingly, a previous work showed that the administration of MK801, another non-competitive NMDAR antagonist, to rats induced an anxiety-like phenotype in the elevated plus-maze ( Solati, 2011 ). In contrast to MK801, high doses of memantine (100 mg/kg) increased time spent in open arms, implying an anxiolytic effect.…”

Section: Discussionmentioning

confidence: 99%

Long-term NMDAR antagonism correlates reduced astrocytic glutamate uptake with anxiety-like phenotype

Zimmer

Torrez

Kalinine

et al. 2015

Front. Cell. Neurosci.

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The role of glutamate N-methyl-D-aspartate receptor (NMDAR) hypofunction has been extensively studied in schizophrenia; however, less is known about its role in anxiety disorders. Recently, it was demonstrated that astrocytic GLT-1 blockade leads to an anxiety-like phenotype. Although astrocytes are capable of modulating NMDAR activity through glutamate uptake transporters, the relationship between astrocytic glutamate uptake and the development of an anxiety phenotype remains poorly explored. Here, we aimed to investigative whether long-term antagonism of NMDAR impacts anxiety-related behaviors and astrocytic glutamate uptake. Memantine, an NMDAR antagonist, was administered daily for 24 days to healthy adult CF-1 mice by oral gavage at doses of 5, 10, or 20 mg/kg. The mice were submitted to a sequential battery of behavioral tests (open field, light–dark box and elevated plus-maze tests). We then evaluated glutamate uptake activity and the immunocontents of glutamate transporters in the frontoparietal cortex and hippocampus. Our results demonstrated that long-term administration of memantine induces anxiety-like behavior in mice in the light–dark box and elevated plus-maze paradigms. Additionally, the administration of memantine decreased glutamate uptake activity in both the frontoparietal cortex and hippocampus without altering the immunocontent of either GLT-1 or GLAST. Remarkably, the memantine-induced reduction in glutamate uptake was correlated with enhancement of an anxiety-like phenotype. In conclusion, long-term NMDAR antagonism with memantine induces anxiety-like behavior that is associated with reduced glutamate uptake activity but that is not dependent on GLT-1 or GLAST protein expression. Our study suggests that NMDAR and glutamate uptake hypofunction may contribute to the development of conditions that fall within the category of anxiety disorders.

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“…Opioid peptides play a role in many functions, including pain perception, respiration, homeothermy, nutrient intake, and the immune response. Moreover, studies have demonstrated the role of opioid receptors in regulating baseline anxiety states and related behaviors (Roeska et al, 2008;Solati 2011;McHugh et al, 2017;Wang et al, 2017). These functions are mediated by three major classes of G protein-coupled receptors, µ, δ and κ, whose activation inhibits adenylyl cyclase (Kahveci et al, 2006).…”

Section: The Effect Of Opioid System On Anxiety Behaviormentioning

confidence: 99%

Modulation of anxiety behavior in gonadectomized animals

Khakpay

Khakpai

2020

Acta Neurobiologiae Experimentalis

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Anxiety is a complex psychological state which happens after stressful life experiences. Many factors such as daily life events, neurotransmitter systems, and different brain areas could influence anxiety behavior in humans and animals. For example, opioids and androgens decrease anxiety behavior both in humans and animals. Furthermore, removing the testes (gonadectomy) causes higher levels of anxiety-like behaviors, in which the administration of testosterone and opioid antagonist can reverse some of these behaviors. We review the effects of morphine and androgens on the modulation of anxiety behavior in gonadectomized animals. We begin by highlighting the effects of opioid drugs and androgens on the modulation of anxiety behavior that have been implicated in anxiety behavior. We then discuss the functional consequences of gonadectomy on anxiety behavior. Finally, we consider how the opioids and androgens may contribute to adaptive responses associated with anxiety.

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Dorsal hippocampal N‐methyl‐d‐aspartate glutamatergic and δ‐opioidergic systems modulate anxiety behaviors in rats in a noninteractive manner

Cited by 17 publications

References 37 publications

Original article Involvement of D 2 /D 2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate

Original article Involvement of D 2 /D 2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate

Long-term NMDAR antagonism correlates reduced astrocytic glutamate uptake with anxiety-like phenotype

Modulation of anxiety behavior in gonadectomized animals

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