Dose and volume parameters for MRI-based treatment planning in intracavitary brachytherapy for cervical cancer

Kirisits, Christian; Pötter, Richard; Lang, Stefan; Dimopoulos, Johannes; Wachter-Gerstner, Natascha; Georg, Dietmar

doi:10.1016/j.ijrobp.2005.02.040

Cited by 296 publications

(177 citation statements)

References 22 publications

Supporting

Mentioning

160

Contrasting

Unclassified

Order By: Relevance

“…The variation of dose was comparable between the two doses, with a standard deviation of 2 Gy for DICRU vs 1.9 Gy for D 2cc ; evaluated for the individual fractions. Two studies have reported a good correlation between D 2cc and DICRU of bladder (Kirisits et al, 2005). However, prior to our study, there were also two studies which observed significant difference between the two doses (Pelloski et al, 2005;Kim et al, 2007).…”

Section: 5259 Ct Based 3-d Treatment Planning Of Brachytherapy For Csupporting

confidence: 43%

“…However, these points are not the best surrogates. Many studies have reported inconsistencies between these points compared with volumetric image-based 3D dose calculation and they cannot be the best estimate to predict late complication to organs at risk (Ling et al, 1987;Schoeppel et al, 1993;Barillot et al, 1994;van der Bergh et al, 1998;Fellner et al, 2001;Jason et al, 2003;Kirisits et al, 2005;Pelloski et al, 2005;Tan et al, 2009;Vinod et al, 2011). Imagebased brachytherapy allows more conformal treatment, integrating the concepts of anatomy, tumour features, and tumour response with time.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

CT Based 3-Dimensional Treatment Planning of Intracavitary Brachytherapy for Cancer of the Cervix : Comparison between Dose-Volume Histograms and ICRU Point Doses to the Rectum and Bladder

Hashim¹,

Jamalludin²,

Ung³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Section: 5259 Ct Based 3-d Treatment Planning Of Brachytherapy For Csupporting

confidence: 43%

Section: Discussionmentioning

confidence: 99%

CT Based 3-Dimensional Treatment Planning of Intracavitary Brachytherapy for Cancer of the Cervix : Comparison between Dose-Volume Histograms and ICRU Point Doses to the Rectum and Bladder

Hashim¹,

Jamalludin²,

Ung³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…These results are expected to be representative of the scenario where a ring applicator is used to mimic a tandem and ovoid geometry, and agree well with a similar study that showed

< 3 %

variation in dose to points A/B, bladder, and rectum. ( 6 ) The dosimetric discrepancies could be larger for nonconventional plans that are more conformal, ( 12 – 13 ) particularly if anterior or posterior dwell positions are used.…”

Section: Discussionmentioning

confidence: 99%

Commissioning of Varian ring & tandem HDR applicators: reproducibility and interobserver variability of dwell position offsets

McMahon

Zhuang

Steffey

et al. 2011

J Applied Clin Med Phys

View full text Add to dashboard Cite

Studies have shown that source dwells within Varian's HDR CT/MR compatible ring applicators can deviate from intended positions by several millimeters. Quantifying this offset is an important part of commissioning. The aims of this study were to: 1) determine the reproducibility of the offset, 2) study the interobserver variation in the offset's measurement, and 3) quantify the dosimetric impact of the offset. Offsets were measured for four ring applicators: two 30°, one 45°, and one 60°. Dwell positions were measured five times for each ring to determine the reproducibility of source positioning. Experiments were done to compare two separate source wires, as well as different time points within a single source wire's lifecycle. Data were analyzed by three independent observers. To quantify the dosimetric impact of the offset, a treatment plan was generated using BrachyVision. The dose to point A, and the normalD2cc metric for rectum and bladder were calculated with and without the offset. For the 45° and 60° rings, measured offsets were 3.0 mm and 3.6 mm, respectively. The 30° ring showed substantial variation in distal dwell positions (maximum difference between the five experiments of 2.9 mm). Subsequent testing of a replacement ring showed an offset of 2.4 mm that was more reproducible. Offsets varied less than 1 mm between different source wires, and changed less than 1 mm over the course of a source wire's lifecycle. When comparing observers, the average range in a measurement of a dwell position was 0. 5mm (σ = 0.2 mm, max 1.3 mm). The offset resulted in dose variations to point A, bladder, and rectum of less than 1%, 2%, and 5%, respectively. Results indicate that Varian rings can show systematic and random offsets of more than 3 mm. Some can be considered defective and should be replaced. Each applicator should be individually commissioned and reproducibility should be confirmed with multiple tests.PACS number: 87.56.‐v, 87.53.Jw

show abstract

“…Dose per fraction was calculated using a biologically equivalent dose of 2 Gy per fraction (EQD2) and linear‐quadratic model with

α / β = 10 Gy

for CTVs and

α / β = 3 Gy

for OARs (2) . GEC‐ESTRO guidelines for contouring and dose constrains on normal tissues and CTVs were observed in treatment planning 12 , 13 , 14 . The treatment aim was to deliver a minimum total dose of 80‐90 Gy to

D_{90}

of the

{CTV}_{HR}

(EQD2).…”

Section: Methodsmentioning

confidence: 99%

A comparison of organs at risk doses in GYN intracavitary brachytherapy for different tandem lengths and bladder volumes

Siavashpour

Aghamiri

Jaberi

et al. 2016

J Applied Clin Med Phys

Self Cite

View full text Add to dashboard Cite

The purpose of this study was to investigate the concurrent effects of tandem length and bladder volume on dose to pelvic organs at risk (OARs) in HDR intracavitary brachytherapy treatment of cervical cancer. Twenty patients with locally advanced cervical cancer were selected for brachytherapy using Rotterdam applicators. The patients were CT scanned twice with empty and full bladder. Two treatment plans were prepared on each of the image sets. Patients were categorized into two groups; those treated with a tandem length of 4 cm or smaller false(T≤4 cmfalse) and those with tandem length larger than 4 cm (T>4 cm). Only one tandem tip angle of 30° was studied. Dose‐volume histograms (DVHs) of OARs were calculated and compared. Bladder dose was significantly affected by both bladder volume and tandem physical length for T≤4 cm. This was reflected on the values obtained for normalD2cm3, normalD1cm3, and normalD0.1cm3 for both empty and full bladder cases. When T>4 cm, no correlation could be established between variations in bladder dose and bladder volume. Rectum dose was generally lower when the bladder was empty and T>4 cm. Dose to sigmoid was increased when T>4 cm; this increase was larger when the bladder was full. Our results suggest that, for tandems longer than 4 cm, keeping the bladder empty may reduce the dose to rectum and sigmoid. This is contrary to cases where a shorter than 4 cm tandem is used in which a full bladder (about 50–120 cm3) tends to result in a lower dose to rectum and sigmoid. Attention should be given to doses to sigmoid with long tandem lengths, as a larger tandem generally results in a larger dose to sigmoid.PACS number(s): 87.53.Jw

show abstract

Dose and volume parameters for MRI-based treatment planning in intracavitary brachytherapy for cervical cancer

Cited by 296 publications

References 22 publications

CT Based 3-Dimensional Treatment Planning of Intracavitary Brachytherapy for Cancer of the Cervix : Comparison between Dose-Volume Histograms and ICRU Point Doses to the Rectum and Bladder

CT Based 3-Dimensional Treatment Planning of Intracavitary Brachytherapy for Cancer of the Cervix : Comparison between Dose-Volume Histograms and ICRU Point Doses to the Rectum and Bladder

Commissioning of Varian ring & tandem HDR applicators: reproducibility and interobserver variability of dwell position offsets

A comparison of organs at risk doses in GYN intracavitary brachytherapy for different tandem lengths and bladder volumes

Contact Info

Product

Resources

About