Dose-Dependent Absorption Profile of Different Magnesium Compounds

Ateş, Mehmet; Kızıldağ, Servet; Yüksel, Oğuz; Hoşgörler, Ferda; Yüce, Zeynep; Güvendi, Güven; Kandiş, Sevim; Karakiliç, Aslı; Koç, Başar; Uysal, Nazan

doi:10.1007/s12011-019-01663-0

Cited by 17 publications

(15 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Currently, several generations of magnesium-containing preparations depending on their pharmacological properties are distinguished (Trisvetova 2012). It was proved that the first-generation drugs, represented by inorganic magnesium compounds, have little effect on the balance of this element in the body (Ates et al 2019;Uysal et al 2019). Magnesium oxide, dioxide, carbonate and phosphate exhibit primarily antacid properties, but are not used in correcting magnesium deficiency.…”

Section: Resultsmentioning

confidence: 99%

“…Second-generation drugs, represented by organic magnesium salts, are well absorbed in the gastrointestinal tract and rarely cause side effects (Gröber et al 2015;Ates et al 2019;Gromova et al 2019). Тhis group of magnesium-containing compounds is represented by such salts as magnesium malate, magnesium gluconate, magnesium orotate, magnesium citrate, magnesium pidolate, and magnesium lactate (Table 2).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Possible prospects for using modern magnesium preparations for increasing stress resistance during COVID-19 pandemic

Sankova

Kytko

Meylanova

et al. 2020

RRP

View full text Add to dashboard Cite

Introduction: The relevance of the issue of increasing stress resistance is due to a significant deterioration in the mental health of the population caused by the special conditions of the disease control and prevention during the COVID-19 pandemic. Recently, the decisive role in the severity of clinico-physiological manifestations of maladjustment to stress is assigned to magnesium ions. The aim of the work was to study the magnesium importance in the body coping mechanisms under stress for the pathogenetic substantiation of the magnesium correction in an unfavorable situation of disease control and prevention during the COVID-19 pandemic. Materials and methods: The theoretical basis of this scientific and analytical review was an analysis of modern Russian and foreign literature data posted on the electronic portals MEDLINE, PubMed-NCBI, Scientific Electronic Library eLIBRARY.RU, Google Academy, and CyberLeninka. Results and discussion: It was shown that the total magnesium level in the body plays the indicator role of the body functional reserves. Acute and chronic stresses significantly increase the magnesium consumption and cause a decrease in its body content. Magnesium deficiency is one of the main pathogenetic mechanisms of reducing stress resistance and adaptive body reserves. Arising during the COVID-19 pandemic, increased nervous and emotional tension, the lack of emotional comfort and balance can lead to the onset or deterioration of magnesium deficiency, which manifests itself in mental burnout and depletion of adaptive capacities. The inability to synthesize magnesium in the body necessitates including foodstuffs high in magnesium in the population diet during this period. The appointment of magnesium preparations is pathogenetically justified with moderate and severe magnesium deficiency. This therapy should take into account the major concomitant diseases, severity of magnesium deficiency, and a patient’s age. Conclusion: magnesium correction, carried out during the COVID-19 pandemic, will contribute to increasing stress resistance, preventing mental diseases and improving the population’s life quality.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Possible prospects for using modern magnesium preparations for increasing stress resistance during COVID-19 pandemic

Sankova

Kytko

Meylanova

et al. 2020

RRP

View full text Add to dashboard Cite

show abstract

“…The limited bioavailability of these forms of magnesium is probably because of insufficient magnesium penetration into brain tissue (30). In our previous study, compared to other forms (magnesium malate, magnesium glycinate), we observed more effective penetration into the brain tissue for magnesium acetyl taurate and magnesium citrate when we implemented the same elemental magnesium doses (3). We observed that these forms passed into the brain tissue more efficiently; however, the effectiveness of these forms on the secondary injury processes in head trauma is open to investigation.…”

mentioning

confidence: 80%

Magnesium acetyl taurate prevents tissue damage and deterioration of prosocial behavior related with vasopressin levels in traumatic brain injured rats

Hoşgörler

Koç²,

Kızıldağ³

et al. 2020

Turkish Neurosurgery

Self Cite

View full text Add to dashboard Cite

AIM:To investigate the effects of different magnesium forms on tissue damage, cognitive and emotional behavioural impairment after mild traumatic brain injury (TBI). MATERIAL and METHODS:Rats were divided into 5 groups (control, trauma, magnesium sulphate, magnesium citrate, magnesium acetyl taurate) and following head trauma, empathy-like behaviour, anxiety-like behaviour (elevated plus maze and open field tests), and depression (forced swim test) were measured. The rats were then sacrificed 12 days later. Oxytocin, vasopressin and receptors levels in the amygdala and prefrontal cortex regions were measured. Histopathological damage (with haematoxylin-eosin staining) and apoptosis (with caspase-3 immunohistochemistry) was evaluated. RESULTS:Following head trauma, anxiety-like behaviour and depression tests did not change; empathy-like behaviour deteriorated on the 3 rd day and improved gradually on the 6 th and 12 th days. Oxytocin, vasopressin and vasopressin v1b receptor levels decreased in the amygdala; morphological damage and apoptosis were significant. Magnesium acetyl taurate effectively ameliorated histopathological deteriorations and improved vasopressin and v1b receptor levels in the amygdala. Transient deterioration of empathy-like behaviour was impeded only in magnesium taurate treatment. CONCLUSION:Magnesium acetyl taurate can be a promising candidate agent to prevent structural and functional damage in traumatic brain injury.

show abstract

“…In a recent report, Mg 2+ chloride or Mg 2+ glycerophospate was suggested rather than Mg 2+ oxide or Mg 2+ sulfate for oral Mg2+ supplementation (1). In a study conducted in mice, the different Mg 2+ preparations (Mg 2+ acetyl taurate; Mg 2+ malate; Mg 2+ magnesium glycinate; Mg 2+ citrate) were shown to be effective in increasing Mg 2+ levels in different tissues like brain and muscle (12). In that study, blood Mg 2+ levels were increased in all doses of Mg 2+ acetyl taurate, malate, and glycinate, whereas Mg 2+ citrate increased blood magnesium levels at high doses.…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 93%

Treatment Difficulties in Hypomagnesemia Secondary to the Transient Receptor Potential Melastatin 6 Gene: A Case Report with Novel Mutation

Yücel

Sel

Kasapkara

et al. 2021

Jcrpe

View full text Add to dashboard Cite

What's known on this topic? Hypomagnesemia is one of the causes of hypocalcemia. Enteral replacement is the key in the treatment but the treatment should be individualized for each patient. Normalization of hypomagnesemia is not always easy and should not be the aim of the treatment. What this study adds? The genetic analysis revealed a novel frame shift variant in the transient receptor potential melastatin 6 genes. The magnesium levels varied during the treatment with different preparations of medication. The treatment should be individualized.

show abstract

Dose-Dependent Absorption Profile of Different Magnesium Compounds

Cited by 17 publications

References 28 publications

Possible prospects for using modern magnesium preparations for increasing stress resistance during COVID-19 pandemic

Possible prospects for using modern magnesium preparations for increasing stress resistance during COVID-19 pandemic

Magnesium acetyl taurate prevents tissue damage and deterioration of prosocial behavior related with vasopressin levels in traumatic brain injured rats

Treatment Difficulties in Hypomagnesemia Secondary to the Transient Receptor Potential Melastatin 6 Gene: A Case Report with Novel Mutation

Contact Info

Product

Resources

About