2008
DOI: 10.1016/j.toxicon.2007.11.005
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Dose-dependent effects of extracted microcystins on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis)

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Cited by 45 publications
(26 citation statements)
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“…digestive tract, pancreas, liver) in newly hatched embryos. An exposure of the fertilized eggs of southern catfish to crude extracted MCs (10-100 μg MC-LReq/L) obviously retarded egg and larval development, reduced hatching rate, caused high malformation rate and hepatocytes damage in larvae (Zhang et al, 2008). On the other hand, MC level in liver and muscle did not show the same pattern with that in intestine and gonad among these three groups of vertebrates, and the possible mechanisms for such a difference remain unclear and need further investigations.…”
Section: Discussionmentioning
confidence: 99%
“…digestive tract, pancreas, liver) in newly hatched embryos. An exposure of the fertilized eggs of southern catfish to crude extracted MCs (10-100 μg MC-LReq/L) obviously retarded egg and larval development, reduced hatching rate, caused high malformation rate and hepatocytes damage in larvae (Zhang et al, 2008). On the other hand, MC level in liver and muscle did not show the same pattern with that in intestine and gonad among these three groups of vertebrates, and the possible mechanisms for such a difference remain unclear and need further investigations.…”
Section: Discussionmentioning
confidence: 99%
“…Palíková et al (2004) and Zhang et al (2008) reported that the characteristic histopathological alterations in fish livers by exposure to cyanotoxins were illustrated as disorganization of cell structure and cellular degeneration with vacuolar hepatocytes. Similar histopathological alterations were also observed in the present study.…”
Section: Effect Of Dietary Cyanobacteria On the Liver Histopathology mentioning
confidence: 99%
“…In addition, the toxins used in these experiments were either purified microsystins (MCs) or cyanobacterial crude extract containing MCs (Li et al, 2005;Hao et al, 2008;Zhang et al, 2008). Generally, cyanobacteria are a normal food component for many fishes (Zurawell et al, 2005) and cyanotoxins were normally intaken by fish through food under natural environments.…”
mentioning
confidence: 99%
“…There is some question as to whether a provisional guideline value can be applied to children and infants when the LOAEL used to calculate that guideline value was derived from a study of adult male rats. There is some evidence in the literature for potential developmental effects of MCs [288,289]. As such it is possible that individuals of a younger age could develop adverse effects later in life due to an exposure at levels lower than 50 µg/kg b.w./day, during critical periods of development.…”
Section: Microcystinmentioning
confidence: 99%