2020
DOI: 10.1126/sciadv.aay3823
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Dose-dependent functions of SWI/SNF BAF in permitting and inhibiting cell proliferation in vivo

Abstract: SWI/SNF (switch/sucrose nonfermenting) complexes regulate transcription through chromatin remodeling and opposing gene silencing by Polycomb group (PcG) proteins. Genes encoding SWI/SNF components are critical for normal development and frequently mutated in human cancer. We characterized the in vivo contributions of SWI/SNF and PcG complexes to proliferation-differentiation decisions, making use of the reproducible development of the nematode Caenorhabditis elegans. RNA interference, lineage-specific gene kno… Show more

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Cited by 27 publications
(53 citation statements)
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“…the time of invasion. In addition to reflecting the dose-dependent nature of the SWI/SNF ATPase in cancer, our data in the AC is consistent with work done in C. elegans early mesoblast development where complete loss of the swsn-4 ATPase using a catalytically dead mutant and lineage-specific knockout strategy results in loss of cell cycle arrest (34). A limitation to our experimental strategy is that we cannot be sure that combining swsn-4 RNAi with an anti-GFP-targeting nanobody to deplete the SWI/SNF ATPase represents a null phenotype, as we limited our analysis to quantitative fluorescence measurements.…”
supporting
confidence: 89%
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“…the time of invasion. In addition to reflecting the dose-dependent nature of the SWI/SNF ATPase in cancer, our data in the AC is consistent with work done in C. elegans early mesoblast development where complete loss of the swsn-4 ATPase using a catalytically dead mutant and lineage-specific knockout strategy results in loss of cell cycle arrest (34). A limitation to our experimental strategy is that we cannot be sure that combining swsn-4 RNAi with an anti-GFP-targeting nanobody to deplete the SWI/SNF ATPase represents a null phenotype, as we limited our analysis to quantitative fluorescence measurements.…”
supporting
confidence: 89%
“…CC-BY-NC-ND 4.0 International license available under a (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made (31,(45)(46)(47), and cell cycle control (34,(48)(49)(50)(51), we chose to focus our efforts on characterizing the role of the SWI/SNF complex in promoting AC invasion.…”
Section: An Rnai Screen Of 270 Chromatin Regulating Factors Identifiementioning
confidence: 99%
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