1995
DOI: 10.1016/0306-4522(95)00066-r
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Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by instrastriatal injection of 6-hydroxydopamine

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Cited by 417 publications
(273 citation statements)
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“…Further, the loss of [ 3 H]-mazindol binding following intrastriatal 6-OHDA correlates well with cell body loss from the SNpc (Przedborski et al, 1995;Lee et al, 1996), and with the degree of striatal dopamine depletion following both 6-OHDA (Ryan & Loiacono, unpublished observations) and methamphetamine treatments (Maggio et al, 1997;1998).…”
mentioning
confidence: 87%
See 1 more Smart Citation
“…Further, the loss of [ 3 H]-mazindol binding following intrastriatal 6-OHDA correlates well with cell body loss from the SNpc (Przedborski et al, 1995;Lee et al, 1996), and with the degree of striatal dopamine depletion following both 6-OHDA (Ryan & Loiacono, unpublished observations) and methamphetamine treatments (Maggio et al, 1997;1998).…”
mentioning
confidence: 87%
“…Such damage mimics the progressive and incomplete nigrostriatal degeneration that characterizes early human PD (Berger et al, 1991;Sauer & Oertel, 1994;Przedborski et al, 1995;Lee et al, 1996). In comparison, excitatory amino acids have been directly implicated in the mechanism of methamphetamine-induced nigrostriatal toxicity (Sonsalla et al, 1989;.…”
mentioning
confidence: 99%
“…The specificity of these drugs takes advantage of the highaffinity systems that recover and recycle released dopamine. Dopamine neurons are specifically killed when the compound 6-hydroxy-dopamine is injected into the striatum of an adult rat (Przedborski et al 1995). The striatum contains the axonal projections of dopamine neurons with cell bodies located in the ventral midbrain.…”
Section: Insulin Protects Dopamine Neurons From 6-ohda Toxicitymentioning
confidence: 99%
“…As DA agonists, including PPX, are front-line therapy for early-stage PD (Bonuccelli et al, 2009), we sought to model the human brain at this stage, that is, when dopaminergic lesions are largely confined to the putamen (Kish et al, 1988). The rodent dorsolateral striatum (DLS) is the homolog of the primate putamen, and lesions of DA inputs to the DLS via 6-OHDA injections are a common way to model early stages of PD in rats (Deumens et al, 2002;Przedborski et al, 1995). Thus, we used this approach to provide a PD model in which to study the effects of ± PPX.…”
Section: Introductionmentioning
confidence: 99%