2008
DOI: 10.1101/sqb.2008.73.018
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Signaling Pathways Controlling Neural Stem Cells Slow Progressive Brain Disease

Abstract: The identification and characterization of multipotent neural precursors open the possibility of transplant therapies, but this approach is complicated by the widespread pathology of many degenerative diseases. Activation of endogenous precursors that support regenerative mechanisms is a possible alternative. We have previously shown that Notch ligands promote stem cell survival in vitro. Here, we show that there is an intimate interaction between insulin and Notch receptor signaling. Notch ligands also expand… Show more

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Cited by 34 publications
(57 citation statements)
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References 79 publications
(83 reference statements)
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“…Several inputs into Hes3 increase its expression and nuclear localization, and promote the growth of NSCs in vitro and in vivo (36,37). In vivo, they increase the number of Hes3ϩ cells and confer powerful neuroprotection in animal models of ischemic stroke and Parkinson disease, likely, in part through the release of trophic factors from Hes3ϩ cells (10,11,15,17,38).…”
Section: Discussionmentioning
confidence: 99%
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“…Several inputs into Hes3 increase its expression and nuclear localization, and promote the growth of NSCs in vitro and in vivo (36,37). In vivo, they increase the number of Hes3ϩ cells and confer powerful neuroprotection in animal models of ischemic stroke and Parkinson disease, likely, in part through the release of trophic factors from Hes3ϩ cells (10,11,15,17,38).…”
Section: Discussionmentioning
confidence: 99%
“…The Hes3 null mouse line is a remarkable one as it has no evident phenotypes, but the biology behind Hes3 suggests that its absence should impact the health of the animal (11). It may be that the answer to this riddle is that Hes3 is not essential under normal conditions but highly convenient to have in instances of damage and stress, either because Hes3 absence can be compensated for under normal conditions by other genes, or because Hes3 function is primarily allocated to damage situations (Fig.…”
Section: Discussionmentioning
confidence: 99%
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