2004
DOI: 10.1016/j.taap.2004.06.019
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Dose-dependent transitions in mechanisms of toxicity

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Cited by 157 publications
(91 citation statements)
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“…Our work also indicated that responses in the low-dose region could vary from superlinear to sublinear, and even to J-shaped curvatures, depending on the strength of homeostatic regulation. Overall, these changing responses are consistent with the socalled dose-dependent transition proposed for many chemical compounds [58,59].…”
Section: Discussionsupporting
confidence: 86%
“…Our work also indicated that responses in the low-dose region could vary from superlinear to sublinear, and even to J-shaped curvatures, depending on the strength of homeostatic regulation. Overall, these changing responses are consistent with the socalled dose-dependent transition proposed for many chemical compounds [58,59].…”
Section: Discussionsupporting
confidence: 86%
“…Actually, another relevant point should be addressed: the dosedependent transitions. A transition is a change with increasing dose in key underlying kinetic and/or dynamic factors that influence the mechanism responsible for the observed toxicity, resulting in a change in the relationship of the response rate as function of dose (Slikker et al, 2004a). The saturable or inducible factors such as absorption, distribution, elimination, metabolism, besides receptor interactions and altered homeostasis are the basis for dose-dependent transitions.…”
Section: Pesticidementioning
confidence: 99%
“…A CRITICAL DOSE LEVEL FOR RISK ASSESSMENT 247 significance of dose-dependent transitions has also more recently been discussed, and it has been argued that consideration of such transitions could improve the risk assessment (Slikker et al, 2004a(Slikker et al, , 2004b. For example, the identification of a transition dose region is suggested to be crucial to properly define the lowest range of doses appropriate for extrapolation, for example between different species.…”
Section: Discussionmentioning
confidence: 99%