Dose-dependent vitamin D3 and 1,25-dihydroxyvitamin D3-induced hypercalcemia and hyperphosphatemia in male cyprinoid Cyprinus carpio

Swarup, K; Das, Vijai Krishna; Norman, Anthony W.

doi:10.1016/0300-9629(91)90497-z

Cited by 30 publications

(20 citation statements)

References 14 publications

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“…Calcitriol [1,25(OH)2 vitamin D 3], the active metabolite of vitamin D in vertebrates, plays a key role in bone forma tion (Haga et al, 2004) and stimulates intestinal calcium absorption (Swarup et al, 1991). Thus, calcitriol will con tribute to a positive shift in calcium uptake and accumula tion and its effects will be hypercalcemic.…”

Section: Mineralisationmentioning

confidence: 99%

Parathyroid hormone-related protein in teleost fish

Abbink

Flik

2007

General and Comparative Endocrinology

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A brief description is given of the discovery of PTHrP and the roles of the peptide in mammalian physiology. Next, the occurrence of PTHrP in the earliest vertebrates, sharks, skates and fishes, is reviewed and the calciotropic functions of PTHrP are addressed more spe cifically in fishes. Parathyroid hormone-related protein (PTHrP) is a hypercalcemic hormone in teleostean fishes, but also has para-and autocrine functions. After the isolation and identification of fish PTHrP and PTHrP receptors and the subsequent development of recom binant protein and a real-time quantitative PCR, a calciotropic role of PTHrP in fish physiology could be assessed. PTHrP influences calcium physiology via regulation of calcium mobilisation from internal sources (bone and scales) and via calcium uptake from the envi ronment (water and diet). Continuous variations in the need for calcium and in the availability of environmental calcium require fast calciotropes to guarantee calcium balance, in which PTHrP is pivotal for the fish. PTHrP is essential in fish bone physiology, e.g. in min eralisation and calcium reabsorption from the scales. Moreover, PTHrP plays a role in vitellogenesis, cortisol production, regulation of renal Mrp2 activity and melatonin synthesis. The plethora of functions of PTHrP in fish concern endocrine, paracrine and autocrine (and possibly intracrine) functions; calciotropic actions of PTHrP at the organismal and cellular level are prominent in fish. The strong con servation of the pthrp gene in the vertebrate lineage and the N-terminal similarity of the coded proteins relates to the important role of PTHrP in calcium physiology that is of paramount importance to all physiological processes. Recent and ongoing studies will contribute to our rapidly expanding knowledge of the original physiological functions of PTHrP in teleost fish.

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Section: Mineralisationmentioning

confidence: 99%

Parathyroid hormone-related protein in teleost fish

Abbink

Flik

2007

General and Comparative Endocrinology

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“…In addition to PTHrP, calcitriol (1.25[OH]2D 3) exerts hypercalcemic effects in fish; it is the active metabolite of vitamin D that plays an important role in bone for mation (Haga et al, 2004) and it stimulates intestinal calcium absorption (Swarup et al, 1991). Sundell et al (1993) demonstrated calcitriol receptors in several cal cium regulating tissues (gill, intestine, kidney) in Atlantic cod (Gadus morhua) and demonstrated increased calcium absorption after calcitriol administration, in line with hypercalcemic function.…”

Section: Introductionmentioning

confidence: 99%

Melatonin synthesis under calcium constraint in gilthead sea bream (Sparus auratus L.)

Abbink

Kulczykowska

Kalamarz

et al. 2008

General and Comparative Endocrinology

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Brain or blood plasma melatonin was analysed as a measure for pineal melatonin production in sea bream. Access to calcium was limited by diluting the seawater to 2.5& and removing calcium from the diet or by prolonged feeding of vitamin D-deficient diet. Inter actions/relations between melatonin and calcium balance and the hypercalcemic endocrines PTHrP and calcitriol were assessed. Restrict ing calcium availability in both water and diet had no effect on plasma melatonin, but when calcium was low in the water or absent from food, increased and decreased plasma melatonin was observed, respectively. Fish on a vitamin D-deficient diet (D-fish) showed decreased plasma calcitriol levels and remained normocalcemic. Decreased brain melatonin was found at all sampling times (10-22 weeks) in the D -fish compared to the controls. A positive correlation between plasma Ca2+ and plasma melatonin was found (R2 = 0.19; N = 41; P < 0.01) and brain melatonin was negatively correlated with plasma PTHrP (R2 = 0.78; N = 4; P < 0.05). The posi tive correlation between plasma levels of melatonin and Ca2+ provides evidence that melatonin synthesis is influenced by plasma Ca2+. The decreased melatonin production in the D -fish points to direct or indirect involvement of calcitriol in melatonin synthesis by the pineal organ in teleosts. The hypercalcemic factors PTHrP and calcitriol appeared to be negatively correlated with melatonin and this substantiates an involvement of melatonin in modulating the endocrine response to cope with hypocalcemia. It further points to the importance of Ca2+ in melatonin physiology.

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“…Vielma & Lall (1998a) hypothesized about a negative relation between phosphorus concentration in the diet and 25(OH)D 3 content in the liver of Atlantic salmon. A hyperphosphatemic effect of vitamin D has been described in eel, A. anguilla (Fenwick et al 1984), catfish, Clarias batrachus (Swarup et al 1984), and carp, Cyprinus carpio (Swarup et al 1991).…”

Section: Introductionmentioning

confidence: 99%

The vitamin D receptor and its ligand 1α,25-dihydroxyvitamin D3 in Atlantic salmon (Salmo salar)

Lock¹,

Ørnsrud²,

Aksnes

et al. 2007

Journal of Endocrinology

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Seaward migration of Salmo salar is preceded by preparatory physiological adaptations (parr-smolt transformation) to allow for a switch from freshwater (FW) to seawater (SW), which also means a switch in ambient calcium from hypocalcic (!1 mM Ca 2C ) to the plasma (w1 . 25 mM Ca 2C ) and to strongly hypercalcic (8-12 mM Ca 2C ). Uptake, storage (skeleton, scales) and excretion of calcium need careful regulation. In fish, the vitamin D endocrine system plays a rather enigmatic role in calcium physiology. Here, we give direct evidence for calcitriol involvement in SW migration. We report the full sequence of the nuclear vitamin D receptor (sVDR0) and two alternatively spliced variants resulting from intron retention (sVDR1 and sVDR2). In FW parr, SW adapting smolts, and in SW adults, plasma concentrations of 25(OH)D 3 and 24,25(OH) 2 D 3 did not change significantly. Plasma calcitriol concentrations were lowest in FW parr, doubled during smoltification and remained elevated in SWadults. Increased calcitriol coincided with a twofold decrease in sVDR mRNA levels in gill, intestine, and kidney of FW smolts and SW adults, when compared with parr. Clearly, there was a negative feedback and dynamic response of the vitamin D endocrine system during parr-smolt transformation. The onset of these dynamic changes in FW parr warrants a further search for the endocrines that initiate these changes. We speculate that the vitamin D system plays a crucial role in calcium and phosphorus handling in Atlantic salmon.

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Dose-dependent vitamin D3 and 1,25-dihydroxyvitamin D3-induced hypercalcemia and hyperphosphatemia in male cyprinoid Cyprinus carpio

Cited by 30 publications

References 14 publications

Parathyroid hormone-related protein in teleost fish

Parathyroid hormone-related protein in teleost fish

Melatonin synthesis under calcium constraint in gilthead sea bream (Sparus auratus L.)

The vitamin D receptor and its ligand 1α,25-dihydroxyvitamin D3 in Atlantic salmon (Salmo salar)

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