Dose–response of intravenous calcium in the surgical intensive care unit

Giuliano, Christopher; Perets, Vitaliy; Hijazi, Mariam; Buck, Joseph R.; Paxton, Renee

doi:10.1007/s11096-020-01145-7

Cited by 2 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moonen, T.S. Breeman, et al , unpublished observation), alongside higher rates of inotropic use in those that normalized calcium levels following supplementation [3]. Collage et al .…”

Section: Management Of Hypocalcaemia In the Icumentioning

confidence: 93%

“…Moonen, T.S. Breeman, et al, unpublished observation), alongside higher rates of inotropic use in those that normalized calcium levels following supplementation [3]. Collage et al [7] concluded that vascular permeability in septic mice increases after a single dose of calcium administration via calcium/ calmodulin-dependent protein kinase signalling, which may further lead to an increased risk of organ dysfunction and death.…”

Section: Management Of Hypocalcaemia In the Icumentioning

confidence: 99%

“…The latest systematic review dating from 2008 concluded that there is no clear evidence that parenteral calcium supplementation impacts the outcome of critically ill patients [49]. One recently published study has focused on the optimal response of serum iCa to calcium supplementation in ICU patients and called for future studies to focus on optimal calcium dosing, although there is no evidence that correction improves outcomes [3]. Other studies even conclude that parenteral calcium in critically ill patients does not adequately improve ionized calcium levels [25,41,50,51].…”

Section: Management Of Hypocalcaemia In the Icumentioning

confidence: 99%

“…There is no doubt that critically ill patients very frequently have low extracellular calcium levels and possibly high intracellular concentrations [1,2]. Serum hypocalcaemia appears to be associated with poorer outcome, which may lead to physicians attempting to correct hypocalcaemia by administering parenteral calcium to critically ill patients without an evidence-based threshold [1,3]. Several recently published studies provide fascinating new insights into managing hypocalcaemia in the ICU, questioning whether it is desirable to supplement calcium in the critically ill.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Management of hypocalcaemia in the critically ill

Melchers

Zanten

2023

Current Opinion in Critical Care

View full text Add to dashboard Cite

Purpose of review To better understand the established associations between hypocalcaemia and clinical outcomes, we synopsize the mechanisms involved in hypocalcaemia in the critically ill. We also provide an overview of the current evidence on managing hypocalcaemia in critical illness. Recent findings Hypocalcaemia is reported to occur in 55–85% of ICU patients. It appears to be associated with poor outcomes. It appears to be associated with poor outcomes, but it may be a marker rather than a direct cause of disease severity. The recommendations to correct calcium in major bleeding are found on weak evidence and require further exploration by a randomized controlled trial (RCT). Calcium administration in cardiac arrest has shown no benefit and may provoke harm. In addition, no RCT has assessed the risks and benefits of calcium supplementation in critically ill hypocalcemic patients. Several recent studies conclude that it may even harm septic ICU patients. These observations are supported by evidence that septic patients using calcium channel blockers may have better outcomes. Summary Hypocalcaemia is common in critically ill patients. Direct evidence that calcium supplementation improves their outcomes is lacking, and there is even some indication that it may be detrimental. Prospective studies are required to elucidate the risks and benefits, and the pathophysiological mechanisms involved.

show abstract

“…Moonen, T.S. Breeman, et al , unpublished observation), alongside higher rates of inotropic use in those that normalized calcium levels following supplementation [3]. Collage et al .…”

Section: Management Of Hypocalcaemia In the Icumentioning

confidence: 93%

Section: Management Of Hypocalcaemia In the Icumentioning

confidence: 99%

Section: Management Of Hypocalcaemia In the Icumentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Management of hypocalcaemia in the critically ill

Melchers

Zanten

2023

Current Opinion in Critical Care

View full text Add to dashboard Cite

show abstract

Advances in Point‐Of‐Care Testing for Emergency Response, Infectious Diseases, and Critical Care — Novel Technologies, Practice Standards, and Improved Outcomes

Füzéry¹,

Kost²,

Tran³

2022

Encyclopedia of Analytical Chemistry

View full text Add to dashboard Cite

We present strategies for point‐of‐care testing ( POCT ) that pave the way for diagnostic portals from homes to intensive care. Now well recognized worldwide by the public and professionals alike, POCT has become ubiquitous. Its scope encompasses mobile field rescue, emergency rooms, and hospital intensive care, where rapid test results help stabilize critically ill patients. We introduce novel technologies and insights for effective application of POCT, including identifying infectious pathogens. We chronicle the discovery of the clinical significance of ionized calcium, the ‘fifth electrolyte,’ an obligatory whole‐blood analyte. We tabulate outcomes associated with whole‐blood analysis, which has progressed significantly across the globe. Progressively endemic, coronavirus disease 2019 is catapulting POCT to new heights. This striking expansion calls for more practical know‐how among laboratorians and public health officials, careful planning of POC strategies in healthcare small‐world networks, and support by national guidelines and policies, especially in limited‐resource settings. Technical, clinical, and cultural advances predict exponential growth as the world embraces faster, smaller, and smarter connected diagnostic decision making where it counts the most, at points of need. This POC paradigm shift means learning novel principles and appreciating new standards for POC devices used on ambulances for emergency rescue, so we start there.

show abstract

Dose–response of intravenous calcium in the surgical intensive care unit

Cited by 2 publications

References 11 publications

Management of hypocalcaemia in the critically ill

Management of hypocalcaemia in the critically ill

Advances in Point‐Of‐Care Testing for Emergency Response, Infectious Diseases, and Critical Care — Novel Technologies, Practice Standards, and Improved Outcomes

Contact Info

Product

Resources

About