Dose–Response of TLD-100 in the Dose Range Useful for Hypofractionated Radiotherapy

Abstract

Purpose: The aim of the study was to exploit the feasibility of thermoluminescent dosimeters (TLDs) in radiation therapy techniques in which high dose per fraction is involved. Methods: Dose–response of TLD-100 (LiF: Mg, Ti) was investigated in both 6-MV photon and 6-MeV electron beams. The element correction factor (ECF) generation method was applied to check the variability of the TLDs response. Two batches of 50 TLDs were divided into groups and exposed in the dose range 0 to 30 Gy. Regression analysis was performed with both linear and quadratic models. For each irradiation beam, the calibration curves were obtained in 3 dose range 0 to 8 Gy, 0 to 10 Gy, and 0 to 30 Gy. The best-fitting model was assessed by the Akaike Information Criterion test. Results: The ECF process resulted a useful tool to reduce the coefficients of variation from original values higher than 5% to about 3.5%, for all the batches exposed. The results confirm the linearity of dose–response curve below the dose level of 10 Gy for photon and electron beam and the supralinear trend above. Conclusion: The TLDs are suitable dosimeters for dose monitoring and verification in radiation treatment involving dose up to 30 Gy in a single fraction.

The Performance of LiF:Mg-Ti for Proton Dosimetry within the Framework of the MoVe IT Project

“…The TLDs are widely used in conventional radiation therapy [31][32][33], while their use in the field of clinical proton beam dosimetry is not currently a routine practice. Despite care being recommended when using TLDs within the distal-off region of the pristine Bragg peak, due to their energy and LET dependence, they are the choice for dosimetry of small fields in which negligible perturbation of the irradiation beam is required.…”

“…The TLDs used were characterized and calibrated with photon, electron, and proton beams in the dose and energy range of interest for clinical applications. The calibration curves for all beams are reported in previously published studies [32,33,39]. According to the entrance energy into the bio-phantom used for the MoVe IT experiments, the corresponding calibration factor was applied to convert the responses of the TLDs to dose values.…”

Feasibility study evaluating arrhythmogenesis and cardiac damage after heart‐base irradiation in mice: A brief communication

“…The thermoluminescent response is not linear for large doses. At high doses, above 10 Gy, it exhibits a supralinear behaviour; this supralinearity has been one of the main drawbacks to their use in high-dose dosimetry (Liuzzi et al, 2020;Liuzzi, Savino, D'Avino, Pugliese, & Cella, 2015). For this reason, a smaller dose was given (with scaled monitor units from the original treatment plan) via the same treatment machine.…”

Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator

“…Dosimetry was performed by using thermoluminescence dosimeters (TLDs), which are proven to be high-performance tools for in vivo dosimetry (IVD) and QA in radiation therapy [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. Comparisons with results obtained by Monte Carlo (MC) simulations and other dosimetry methods (e.g., ionizing chambers or gafchromic films) showed good agreement in HDR BT treatments [ 13 ].…”