Dose-Response Relationship Between Prevalence of Cerebrovascular Disease and Ingested Inorganic Arsenic

Chiou, Hung Yi; Huang, Wei; Su, Che Long; Chang, Shui-Feng; Hsu, Yi Hsiang; Chen, Chien Jen

doi:10.1161/01.str.28.9.1717

Cited by 251 publications

(142 citation statements)

References 32 publications

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“…The finding of a strikingly increased prevalence of macrovascular diseases observed in the arseniasis-endemic area compared with the nonendemic area is consistent with our previous findings of arsenic-induced atherosclerosis (Chen et al 1988bChiou et al 1997b;Tseng et al 1996;Wang et al 2002;Wu et al 1989). There have been few studies comparing the prevalence of specific vascular diseases in relation to arsenic exposure in diabetics and nondiabetics.…”

Section: Discussionsupporting

confidence: 92%

“…Other chronic health effects induced by arsenic have also drawn global attention, especially cardiovascular, neurologic, reproductive, and developmental hazards (Chen et al 1997a(Chen et al , 1999. Mortality and morbidity of vascular diseases, including peripheral vascular disease, cerebral infarction, and ischemic heart disease, have been documented to be associated with arsenic levels in drinking water in the arseniasisendemic area (Chen et al 1988bChiou et al 1997b;Tseng et al 1996;Wang et al 2002;Wu et al 1989). The associations between long-term exposure to arsenic and microvascular diseases, including renal disease, retinopathy, and neuropathy, remain to be elucidated.…”

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confidence: 99%

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Prevalence of non-insulin-dependent diabetes mellitus and related vascular diseases in southwestern arseniasis-endemic and nonendemic areas in Taiwan.

Wang

Chiou

Chen

et al. 2003

Environ Health Perspect

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138

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There is evidence indicating that ingestion of arsenic may predispose the development of diabetes mellitus in arsenic-endemic areas in Taiwan. However, the prevalence of diabetes and related vascular diseases in the entire southwestern arseniasis-endemic and nonendemic areas remains to be elucidated. We used the National Health Insurance Database for 1999-2000 to derive the prevalence of non-insulin-dependent diabetes and related vascular diseases by age and sex among residents in southwestern arseniasis-endemic and nonendemic areas in Taiwan. The study included 66,667 residents living in endemic areas and 639,667 in nonendemic areas, all ≥ 25 years of age. The status of diabetes and vascular diseases was ascertained through disease diagnosis and treatment prescription included in the reimbursement claims of clinics and hospitals. The prevalence of non-insulin-dependent diabetes, age-and gender-adjusted to the general population in Taiwan, was 7.5% (95% confidence interval, 7.4-7.7%) in the arseniasis-endemic areas and 3.5% (3.5-3.6%) in the nonendemic areas. Among both diabetics and nondiabetics, higher prevalence of microvascular and macrovascular diseases was observed in arseniasis-endemic than in the nonendemic areas. Age-and gender-adjusted prevalence of microvascular disease in endemic and nonendemic areas was 20.0% and 6.0%, respectively, for diabetics, and 8.6% and 1.0%, respectively, for nondiabetics. The corresponding prevalence of macrovascular disease was 25.3% and 13.7% for diabetics, and 12.3% and 5.5% for nondiabetics. Arsenic has been suggested to increase the risk of non-insulin-dependent diabetes mellitus and its related micro-and macrovascular diseases.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Prevalence of non-insulin-dependent diabetes mellitus and related vascular diseases in southwestern arseniasis-endemic and nonendemic areas in Taiwan.

Wang

Chiou

Chen

et al. 2003

Environ Health Perspect

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138

111

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“…Previous research of the effects of chronic exposure to iAs has focused primarily on its carcinogenic potential. However, chronic exposures to iAs from the environment or in occupational settings have also been linked to non-carcinogenic diseases, including peripheral vascular disease, cardiovascular and cerebrovascular diseases Chen et al, 1996;Chiou et al, 1997;Engel et al, 1994;Thomas and Goyer, 1995;Tseng et al, 1995;Tseng et al, 1997), hypertension , goiter (Chang et al, 1991), hepatomegaly (Santra et al, 1999), respiratory system dysfunction (Mazumder et al, 2000), nervous system dysfunction (Bencko et al, 1977;Chisolm Jr. and Thomas, 1983;Masahiko and Hideyasu, 1973), and diabetes mellitus (Lai et al, 1994;Rahman et al, 1998;Rahman et al, 1999;Tseng et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Examination of the effects of arsenic on glucose homeostasis in cell culture and animal studies: Development of a mouse model for arsenic-induced diabetes

Paul

Hernández-Zavala

Walton

et al. 2007

Toxicology and Applied Pharmacology

125

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Previous epidemiologic studies found increased prevalences of type 2 diabetes mellitus in populations exposed to high levels of inorganic arsenic (iAs) in drinking water. Although results of epidemiologic studies in low-exposure areas or occupational settings have been inconclusive, laboratory research has shown that exposures to iAs can produce effects that are consistent with type 2 diabetes. The current paper reviews the results of laboratory studies that examined the effects of iAs on glucose metabolism and describes new experiments in which the diabetogenic effects of iAs exposure were reproduced in a mouse model. Here, weanling male C57BL/6 mice drank deionized water with or without the addition of arsenite (25 or 50 ppm As) for 8 weeks. Intraperitoneal glucose tolerance tests revealed impaired glucose tolerance in mice exposed to 50 ppm As, but not to 25 ppm As. Exposure to 25 and 50 ppm As in drinking-water resulted in proportional increases in the concentration of iAs and its metabolites in the liver and in organs targeted by type 2 diabetes, including pancreas, skeletal muscle and adipose tissue. Dimethylarsenic was the predominant form of As in the tissues of mice in both 25 and 50 ppm groups. Notably, the average concentration of total speciated arsenic in livers from mice in the 50 ppm group was comparable to the highest concentration of total arsenic reported in the livers of Bangladeshi residents who had consumed water with an order of magnitude lower level of iAs. These data suggest that mice are less susceptible than humans to the diabetogenic effects of chronic exposure to iAs due to a more efficient clearance of iAs or its metabolites from target tissues.

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“…Chronic exposure to high levels of arsenic concentration in drinking water has been associated with cancers of skin, lung, liver, kidney in different arsenic-affected parts of the world (Brown et al 1989;Hertz-Picciotto and Smith 1993;Buchet and Lison 1998). Arsenic poisoning has also been blamed for several cardiovascular, cerebrovascular endocrine-disrupting and neuro-developmental diseases (Chen et al 1995Chiou et al 1997;Tsai et al 2003;Tseng 2003;Wasserman et al 2004). Even at low to moderate dose of arsenic poisoning adverse health effects in the form of premalignant skin lesions, high blood pressure, and neurological dysfunctions have been reported in the arsenic longitudinal study in Bangladesh by Chen et al (2009).…”

Section: Occurrence and Causes Of Arsenic Contamination Of Groundwatermentioning

confidence: 99%

Contamination of groundwater by arsenic: a review of occurrence, causes, impacts, remedies and membrane-based purification

Pal¹,

Sen²,

Manna³

et al. 2009

Journal of Integrative Environmental Sciences

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The contamination of groundwater by leached out arsenic has assumed an alarming proportion in several countries. Continued and prolonged ingestion even at a very low level can lead to serious arsenic-related diseases. Strong epidemiological evidence of arsenic carcinogenicity has forced the World Health Organization (WHO) to lower the maximum permissible contaminant limit (MCL) in drinking water to 10 ppb from earlier limit of 50 ppb. This has thrown a big challenge to the scientific community to devise efficient methods to purify contaminated water to such a high level. Though literature abounds in occurrence of groundwater contamination by arsenic and its removal from drinking water by laboratory techniques, millions of people continue to suffer, particularly in the developing countries like India (Bangladesh, West Bengal). Through a comprehensive review of the existing literature on the occurrence, causes, impacts and remedial measures, this article finds out what has gone wrong and what is to be done with special emphasis on membrane-based separation that seems to be highly promising in purifying arsenic-contaminated groundwater to a WHOprescribed level.

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Dose-Response Relationship Between Prevalence of Cerebrovascular Disease and Ingested Inorganic Arsenic

Abstract: Long-term exposure to inorganic arsenic from well water was associated with an increased prevalence of cerebrovascular disease, especially cerebral infarction.

Cited by 251 publications

References 32 publications

Prevalence of non-insulin-dependent diabetes mellitus and related vascular diseases in southwestern arseniasis-endemic and nonendemic areas in Taiwan.

Prevalence of non-insulin-dependent diabetes mellitus and related vascular diseases in southwestern arseniasis-endemic and nonendemic areas in Taiwan.

Examination of the effects of arsenic on glucose homeostasis in cell culture and animal studies: Development of a mouse model for arsenic-induced diabetes

Contamination of groundwater by arsenic: a review of occurrence, causes, impacts, remedies and membrane-based purification

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