Dose‐response relationship between weight status and clinical outcomes in pediatric influenza‐related respiratory infections

Okubo, Yusuke; Michihata, Nobuaki; Uda, Kazuhiro; Morisaki, Naho; Miyairi, Isao; Matsui, Hiroki; Fushimi, Kiyohide; Yasunaga, Hideo

doi:10.1002/ppul.23927

Cited by 17 publications

(20 citation statements)

References 24 publications

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“…Finally, even though the previous studies showed positive associations between urinary BPA and obesity among both children and adults using the NHANES database, several cohort and cross‐sectional studies in the United States and other countries did not support these findings . Further cumulative reliable evidence based on prospective cohort studies are needed to confirm whether the association between BPA and obesity is causal or spurious associations.…”

Section: Discussionmentioning

confidence: 99%

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Serial cross‐sectional study for the association between urinary bisphenol A and paediatric obesity: Recent updates using NHANES 2003‐2014

2019

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Background: Several studies have reported bisphenol A (BPA) as a potential risk factor for paediatric obesity, but the findings were inconsistent among these studies. Methods:Using data from the National Health and Nutrition Examination Survey from 2003 to 2014, we conducted a serial cross-sectional study to examine the association between urinary BPA and paediatric obesity among children aged 6 and 19 years. The association between paediatric obesity and urinary BPA concentrations with or without urinary creatinine adjustments was assessed using multivariable regression and cubic spline models fitted for regression models. Results:We observed decreasing trends in urinary BPA concentrations from 2003 to 2014. The associations between urinary BPA concentrations and obesity were inconsistent across the years of survey and even after different models for urinary creatinine adjustments were used. Children with obesity were positively associated with urinary creatinine concentrations, but was not with creatinine-adjusted models.Furthermore, children with higher urinary BPA concentrations had elevated odds of obesity during 2003 to 2008, whereas these associations were inconsistent during 2009 to 2014. Conclusions:The associations between paediatric obesity and urinary BPA concentrations differed across the years of survey and creatinine adjustments. Further studies are required to assess these discrepancies. KEYWORDSurinary bisphenol A, cubic spline model

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Section: Discussionmentioning

confidence: 99%

“…The prevalence of childhood obesity increased between the period from 1990 to 2007 and then leveled off . Recently, several studies have reported that paediatric obesity was associated with high illness severity for acute and chronic diseases, and the health care costs attributable to obesity were gradually rising …”

Section: Introductionmentioning

confidence: 99%

Serial cross‐sectional study for the association between urinary bisphenol A and paediatric obesity: Recent updates using NHANES 2003‐2014

2019

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“…Finally, a total of 7 studies were included in the quantitative analysis [45][46][47][48][49][50][51]. Five more studies [52][53][54][55][56] were included in the qualitative analysis.…”

Section: Study Selection Study Characteristicsmentioning

confidence: 99%

Obesity as a risk factor for severe influenza infection in children and adolescents: a systematic review and meta-analysis

Vitoratou

Milas

Korovessi

et al. 2022

Preprint

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Purpose Obesity has been recently identified as a predisposing factor for worse prognosis in viral illnesses such as SARS-CoV-2, however, its role in children with influenza is not yet clarified. The current systematic review and meta-analysis aims to assess whether obesity is a risk factor for either hospitalization or worse prognosis when hospitalized among children infected by influenza. Methods We systematically searched the following databases: MEDLINE, Clinicaltrials.gov, and Cochrane Central Register of Controlled Trials (CENTRAL) using a structured algorithm. Statistical meta-analysis was performed using the ‘meta’ package in R software and included studies were evaluated using the Newcastle-Ottawa scale. ResultsAmong children with influenza, obesity increased the odds of hospitalization with a pooled OR of 1.89 (95% CI [1.23, 2.9], I2=0, p=0.003). When hospitalized, children with obesity were also more likely to have a worse outcome than their healthy-weight counterparts, with a pooled OR of 1.24 (95% Cl [1.02;1.51], I2=11, p=0.03). In an effort to lower heterogeneity Leave-one-out meta-analysis was conducted. Publication bias was assessed with the visual inspection of funnel plots and the trim-and-fill method. Certainty assessment was evaluated using the GRADE score. ConclusionsThe findings of our meta-analysis suggest that obesity in children with influenza is associated with a worse prognosis; both hospitalization and ICU admission/death. //

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“…al, found similar findings across multiple diagnoses, including respiratory syncytial virus and influenza. Each lower respiratory tract disease was studied separately, however 7,8 …”

Section: Introductionmentioning

confidence: 99%

Effect of childhood obesity on admissions for respiratory disease

et al. 2021

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Aim The purpose of this study was to assess for an association between higher body mass index and disease severity, morbidity and mortality in children admitted for an acute respiratory distress and failure. Methods A single‐institution retrospective cross‐sectional study performed in the United States evaluating paediatric patients, 2–20 years of age, admitted for diagnoses related to acute respiratory distress and acute respiratory failure. Main outcomes include disease severity as assessed using the respiratory component of the Paediatric Early Warning Score (PEWS) with adjustment for altered mental status (Resp‐PEWS + AMS), hospital or intensive care length of stay (LOS) and death. Results Children with obesity made up 42/334 (13%) of the cohort. There was no significant difference in Resp‐PEWS + AMS between obese and non‐obese cohorts (mean of 0.93, {standard deviation 1.11} vs. 1.13 {1.35}, range 0–6, rank sum p = 0.46). There was no significant difference in overall hospital LOS or intensive care LOS. Multivariate analysis including diagnosis as a control variable did not change the results. Conclusion We found that body habitus was not an independent factor for illness severity or clinical outcomes.

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Dose‐response relationship between weight status and clinical outcomes in pediatric influenza‐related respiratory infections

Abstract: These findings demonstrated that underweight status is a risk factor for repeated hospital admissions because of influenza-related respiratory infections in children.

Cited by 17 publications

References 24 publications

Serial cross‐sectional study for the association between urinary bisphenol A and paediatric obesity: Recent updates using NHANES 2003‐2014

Serial cross‐sectional study for the association between urinary bisphenol A and paediatric obesity: Recent updates using NHANES 2003‐2014

Obesity as a risk factor for severe influenza infection in children and adolescents: a systematic review and meta-analysis

Effect of childhood obesity on admissions for respiratory disease

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