Dose-Response relationship of luteinizing hormone to luteinizing hormone—releasing hormone in man

Kastin, Abba J.; Gual, Carlos García; Midgley, A. Rees; Miller, Max; Cabeza, Angela

doi:10.1172/jci106641

Cited by 35 publications

(10 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that a highly purified LH-RH caused a significant increase in plasma LH and FSH values (Kastin et al, 1969) and the present study employed synthetic LH-RH again demonstrated that LH-RH released FSH as well as LH, even though the response of FSH was less as compared with that of LH, supporting a view that LH-RH has an intrinsic activity of FSH-RH (Schally et al, 1917a(Schally et al, , 1971bKastin et al, 1971).…”

supporting

confidence: 80%

Effects of Synthetic Luteinizing Hormone-Releasing Hormone on Plasma Levels of Luteinizing Hormone and Follicle-Stimulating Hormone in Man

et al. 1972

View full text Add to dashboard Cite

supporting

confidence: 80%

Effects of Synthetic Luteinizing Hormone-Releasing Hormone on Plasma Levels of Luteinizing Hormone and Follicle-Stimulating Hormone in Man

et al. 1972

View full text Add to dashboard Cite

“…Previous studies have shown that adult men and women respond to the administration of highly purified porcine LH-RH with a significant release of LH [5][6][7]. No significant difference in response between men and women was found [5].…”

Section: Discussionmentioning

confidence: 88%

“…Administration of porcine LH-RH clearly was shown to increase levels in serum of LH and follicle-stimulating hormone (FSH) in normal men and women [5], even when injected subcutaneously [6]. A linear log dose-response relation has been demonstrated with this material [7]. The increased release of gonadotropins occurred regardless of whether the initial levels of LH and FSH were elevated, as in postmenopausal women [6] and in men [8] pretreated with clomiphene, or whether LH was suppressed by estrogen or an oral contraceptive [5,6].…”

Section: Introductionmentioning

confidence: 81%

Characterization of the Hormonal Responses to Luteinizing Hormone-Releasing Hormone (LH-RH) in Prepubertal and Adult Subjects

et al. 1972

Self Cite

View full text Add to dashboard Cite

ExtractLuteinizing hormone-releasing hormone (LH-RH), purified from porcine hypothalamic tissue, was administered in an intravenous dose of 300 /xg to four prepubertal and four adult human subjects. The resulting increases in plasma levels of LH and FSH were statistically significant (P < 0.01) in the 16-and 32-min samples, but did not differ with the age or sex of the subject groups. The mean maximum increase in plasma LH values was 290% for men and 425% for women. Injection of LH-RH resulted in a 500% mean maximum increase in LH levels in the plasma of boys and 850% in that of girls. The gonadotropin release induced by injection of LH-RH was sufficient to increase plasma levels of estradiol in some individuals. No significant elevation occurred in the levels in plasma of growth hormone, thyrotropin, or cortisol. It is concluded that LH-RH is a potent and specific hypothalamic releasing hormone for LH and FSH in prepubertal children as well as in normal adults. SpeculationThe increases in gonadotropin levels in plasma of all groups seem to reduce the possibility that a change in pituitary responsiveness to LH-RH occurs at puberty. However, similar studies involving larger numbers of individuals tested at varying doses might reveal differences in responses to LH-RH between age or sex groups.

show abstract

“…These early studies uniformly administered pharmacologic quantities of GnRH stimulation to men, women, and children within intact, endogenous GnRH secretion. In one study, individual doses of GnRH (up to 3,000 µg) were often administered weeks apart [1,2,3,4,5]. Despite these limitations of dose and frequency and the potential interference of endogenous GnRH secretion, significant linear dose-response relationships between the log of the GnRH dose and pituitary LH secretion were described when such pharmacologic doses were utilized [1,2,3, 6].…”

Section: Introductionmentioning

confidence: 99%

Interplay between Dose and Frequency of GnRH Administration in Determining Pituitary Gonadotropin Responsiveness

Hughes¹,

Boepple²,

Crowley³

et al. 2007

Neuroendocrinology

View full text Add to dashboard Cite

Background/Aims: The dose, frequency and contour of GnRH stimulation of the pituitary gonadotrope have been shown to be independent variables influencing pituitary LH secretion. The dynamic interaction between these variables during physiological and pathophysiological states has yet to be examined. Methods: Twelve men with GnRH deficiency and idiopathic hypogonadotropic hypogonadism undergoing GnRH therapy participated in a series of studies in which 2 log orders of GnRH doses (2.5–250 ng/kg) were administered at frequencies varying from 0.5 to 8 hourly. Pituitary responses were characterized by pulse amplitudes and nadirs. The relative sensitivity of the gonadotrope to GnRH was defined as that dose of GnRH capable of eliciting an LH pulse amplitude equal to the mean LH amplitude in normal men. Results: As GnRH stimulation of the gonadotrope slowed from 0.5 to 8 hourly, pulse amplitudes of LH increased whereas mean nadirs decreased (p < 0.05). Unique, curvilinear dose-response curves were found for each frequency that demonstrated an increasing slope (p < 0.03) as the frequency of GnRH stimulation slowed. Thus, the relative sensitivity of the gonadotrope increased as the frequency of GnRH stimulation decreased over the range of physiological frequencies tested. Conclusions: We conclude that a delicate interplay exists between the dose and frequency of GnRH stimulation of the gonadotrope that determines pituitary LH gonadotropin responsiveness in the human. Slower frequencies favor increased LH release largely due to decreasing LH nadirs and improved sensitivity of the gonadotropes to GnRH stimulation.

show abstract

Dose-Response relationship of luteinizing hormone to luteinizing hormone—releasing hormone in man

Cited by 35 publications

References 11 publications

Effects of Synthetic Luteinizing Hormone-Releasing Hormone on Plasma Levels of Luteinizing Hormone and Follicle-Stimulating Hormone in Man

Effects of Synthetic Luteinizing Hormone-Releasing Hormone on Plasma Levels of Luteinizing Hormone and Follicle-Stimulating Hormone in Man

Characterization of the Hormonal Responses to Luteinizing Hormone-Releasing Hormone (LH-RH) in Prepubertal and Adult Subjects

Interplay between Dose and Frequency of GnRH Administration in Determining Pituitary Gonadotropin Responsiveness

Contact Info

Product

Resources

About