Dose Response to a Single Intramuscular Injection of FSH Dissolved in Polyvinylpyrrolidone for Superovulation in Cows.

Yamamoto, Masao; Ooe, Masato; Kawaguchi, Mamoru; Suzuki, Takahiro

doi:10.1262/jrd.41.93

Cited by 10 publications

(7 citation statements)

References 18 publications

(12 reference statements)

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“…For example, a single superovulation injection with FSH in degradable polymers to sustain hormone release has been studied in ruminants (Lopez-Sebastian et al 1993;Yamamoto et al 1994;Satoh et al 1996;Sugano and Shinogi 1999;D'Alessandro et al 2001;Kimura et al 2007;Tribulo et al 2012). In cattle, administration of FSH dissolved in various substances, including polyvinylpyrrolidone, aluminum hydroxide gel https://doi.org/10.17221/52/2016-VETMED or hyaluronan (HA), increased ovarian responses compared to multiple FSH injections (Bo et al 1994;Yamamoto et al 1995;Kimura et al 2007;Tribulo et al 2012;Chasombat et al 2013). HA is a biological polymer that is abundantly expressed in many tissues.…”

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confidence: 99%

A simplified superovulation protocol using split-single administration of Folltropin®-V in hyaluronan: application to purebred sheep

Panyaboriban¹,

Suwimonteerabutr²,

Swangchan-Uthai³

et al. 2018

Vet. Med. - Czech

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ABSTRACT:Superovulation is an important step in assisted reproductive technology. Due to its short half-life, follicle stimulating hormone is usually given twice daily to ewes for three to five days, which is both time-and labour-intensive. However, dissolving follicle stimulating hormone in degradable polymers to delay absorbtion has been effective in ruminants. Experiment 1 was performed to compare a split-single follicle stimulating hormone dissolved in hyaluronan (S group; 150 mg follicle stimulating hormone on the first day and 30 mg 48 h later; n = 21) and six decreasing doses of follicle stimulating hormone (M group; 50, 50, 30, 30, 10 and 10 mg; n = 22) at 12-h intervals. Ovarian responses and numbers of recovered ova/embryos did not differ significantly between groups. However, there tended to be more Grade 1 and 2 embryos in S vs M groups (mean ± SEM, 5.1 ± 4.9 vs 2.9 ± 2.9, respectively; P = 0.08). Experiment 2 tested the effectiveness of a simplified split-single follicle stimulating hormone in purebred sheep on a commercial farm. The numbers of recovered good-grade embryos (day 2) were 4.8 ± 5.0 and 4.0 ± 2.5 per donors in Corriedale and Bond sheep breeds, respectively. We conclude that this modified technique for ewe superovulation improved animal welfare, reduced animal handling and labour and yielded results similar to or better than conventional twice-daily follicle stimulating hormone treatments.

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mentioning

confidence: 99%

A simplified superovulation protocol using split-single administration of Folltropin®-V in hyaluronan: application to purebred sheep

Panyaboriban¹,

Suwimonteerabutr²,

Swangchan-Uthai³

et al. 2018

Vet. Med. - Czech

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“…A single injection of FSH dissolved in polyvinylpyrrolidone (PVP) for superovulation has been studied [13], but, the efficiency of superovulation using a single injection compared to multiple injections with FSH is controversial, producing results that are less effective [7,14] or similar [15,16] to multiple injection approaches. Alternatively, Sugamo and Watanabe [17] showed that administration of 16 mg FSH-R over 3 days was sufficient to induce superovulation in Japanese Black cattle.…”

mentioning

confidence: 99%

The Effect of Reduced Dose and Number of Treatments of FSH on Superovulatory Response in CIDR-Treated Korean Native Cows

Son

Choe

Cho

et al. 2007

Journal of Reproduction and Development

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Abstract. The objective of this study was to investigate the effect of dosage and number of days of follicle stimulating hormone (FSH) treatment on superovulatory response in controlled internal drug release (CIDR)-treated Korean native cows. Forty cows underwent two superovulatory treatments with a crossover design. Cows, at random stages of the estrous cycle, received a CIDR together with injections of 1 mg estradiol benzoate and 50 mg progesterone, and gonadotropin treatment began 4 days later. The cows were divided into 2 groups based on the dosage and number of days of treatment with porcine FSH; a total of 28 mg FSH was given in twice daily intramascular injections in decreasing doses over 4 days (5, 5, 4, 4, 3, 3, 2 and 2 mg; T1 group, n=20) or a total of 24 mg FSH was given in twice daily decreasing doses over 3 days (5, 5, 4, 4, 3 and 3 mg; T2 group, n=20). This was followed by the alternate treatment in the subsequent superovulation. The cows were treated identically in all other respects. PGF2α (25 mg and 15 mg) was given with the 5 th and 6 th injections of FSH, CIDR were withdrawn at the 6 th FSH injection and the cows received 200 µg GnRH 36 h after CIDR withdrawal. The cows were artificially inseminated twice, at 48 and 60 h after CIDR withdrawal, using commercial semen from four Korean native bulls, and embryos were recovered 6 or 7 days after the 2 nd insemination. The numbers of corpora lutea (CL; 7.9 ± 1.0 vs. 8.3 ± 1.1) and large follicles (1.2 ± 0.2 vs. 1.3 ± 0.3) present at the time embryo recovery, as detected by ultrasonography, did not differ between the T1 and T2 groups (P>0.05). Similarly, the numbers of total ova/embryos (6.2 ± 0.9 vs. 6.4 ± 1.1), transferable embryos (3.4 ± 0.8 vs. 3.2 ± 0.7), degenerate embryos (0.8 ± 0.2 vs. 1.0 ± 0.3) and unfertilized ova (2.1 ± 0.5 vs. 2.2 ± 0.5) did not differ between the groups (P>0.05). These data indicate that a reduced dose (24 vs. 28 mg) and number of treatments (6 vs. 8) of FSH for superovulation of CIDR-treated Korean native cows does not affect the embryo yield.

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“…Polyvinylpyrrolidone (PVP) is a diluent polymer suitable for prolonging the absorption of pFSH after a single intramuscular (im) administration [12][13][14][15][16][17][18]. However, PVP is viscous and difficult to mix with pFSH.…”

Section: Introductionmentioning

confidence: 99%

Superovulatory response in Japanese Black cows receiving a single subcutaneous porcine follicle–stimulating hormone treatment or six intramuscular treatments over three days

Hiraizumi

Nishinomiya

Oikawa³

et al. 2015

Theriogenology

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Dose Response to a Single Intramuscular Injection of FSH Dissolved in Polyvinylpyrrolidone for Superovulation in Cows.

Cited by 10 publications

References 18 publications

A simplified superovulation protocol using split-single administration of Folltropin®-V in hyaluronan: application to purebred sheep

A simplified superovulation protocol using split-single administration of Folltropin®-V in hyaluronan: application to purebred sheep

The Effect of Reduced Dose and Number of Treatments of FSH on Superovulatory Response in CIDR-Treated Korean Native Cows

Superovulatory response in Japanese Black cows receiving a single subcutaneous porcine follicle–stimulating hormone treatment or six intramuscular treatments over three days

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