Dose tapering for ciclosporin in cats with nonflea‐induced hypersensitivity dermatitis

Abstract

Results suggest that the induction dose of 7 mg/kg ciclosporin can be tapered as soon as 4 weeks without deterioration of the clinical response. Establishment of the lowest effective dosing regimen of ciclosporin reduced the frequency of AEs.

Comparison of FEDESI and SCORFAD scoring systems for the evaluation of skin lesions in allergic cats

“…Ciclosporin was administered at a starting dose of 7 mg/kg per os every 24 h for 1 month. If the animal improved, the frequency of administration was then tapered to every other day after the first month and to twice weekly after the second month, according to a predetermined criterion . Ciclosporin was administered for 3 months and there were four monthly visits for each cat.…”

“…Two different methods to evaluate skin lesions associated with feline allergic dermatitis have been proposed . The “Feline Dermatitis Extent and Severity Index” (FeDESI) is similar to the “Canine Atopic Dermatitis Extent and Severity Index” (CADESI) and evaluates the severity of erythema, excoriations/erosions and self‐induced alopecia at 42 body sites with a 0–5 point scale (maximum score 630) .…”

Clinical efficacy and safety following dose tapering of ciclosporin in cats with hypersensitivity dermatitis

“…This agrees with previous reports from a similar study in European cats with HD, where up to 70% of cats had their CsA dosing frequency reduced to at least EOD, and 57% were maintained on TW dosing. 7 A reduction in dosing frequency has also been reported in a retrospective study of cats treated with CsA for idiopathic pruritus, eosinophilic plaque, indolent ulcer and/ or linear granuloma. 8 Although a range of dosages was used in the study by Vercelli et al, 8 after an 8 week induction period of daily dosing, all cats with these conditions could be clinically maintained on a reduced dosing frequency of EOD or less.…”

Ciclosporin and the cat: Current understanding and review of clinical use

“…When using CsA at the recommended daily dose (7 mg/kg Po or, before 2011, 25 mg/cat), the most commonly reported adverse effects have been gastrointestinal (GI). 33,[35][36][37][38][39][40] In a study specifically addressing adverse effects in cats treated with CsA, vomiting occurred in 12% of cats and soft stools or diarrhoea in 16% of cats. 38 GI adverse effects are often temporary and many disappear within the first few weeks of treatment.…”