2019
DOI: 10.1186/s12936-019-3072-8
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Doses of chloroquine in the treatment of malaria by Plasmodium vivax in patients between 2 and 14 years of age from the Brazilian Amazon basin

Abstract: BackgroundA total dose of chloroquine of 25 mg/kg is recommended by the World Health Organization (WHO) to treat malaria by Plasmodium vivax. In several endemic areas, including the Brazilian Amazon basin, anti-malarial drugs are dispensed in small plastic bags at a dosing regimen based on age. This practice can lead to suboptimal dosing of the drug, which can impact treatment outcomes. The aim of the present study was to estimate the extent of sub-dosing of chloroquine in children and adolescents with vivax m… Show more

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Cited by 14 publications
(6 citation statements)
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“…The use of suboptimal chloroquine dosing also increases the risk of recurrent P. vivax [49]. In a meta-analysis of individual pooled patient data, increasing the total dose of chloroquine from 25 mg/kg to 30 mg/kg, was predicted to reduce the number of recurrent infections by 41% in young children [50].…”
Section: Trends In Parasitologymentioning
confidence: 99%
“…The use of suboptimal chloroquine dosing also increases the risk of recurrent P. vivax [49]. In a meta-analysis of individual pooled patient data, increasing the total dose of chloroquine from 25 mg/kg to 30 mg/kg, was predicted to reduce the number of recurrent infections by 41% in young children [50].…”
Section: Trends In Parasitologymentioning
confidence: 99%
“…2529 patients were excluded, resulting in 6879 patients from 23 studies (one unpublished) and 16 countries in the final analysis ( figure 1 ; appendix pp 10–17 ). 14 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 In the post-hoc systematic review in Scopus, we did not identify additional eligible studies.
Figure 1 Study selection *Includes all patients from four studies excluded on patient-level factors ( appendix p 13 ) and individual patients from additional studies.
…”
Section: Resultsmentioning
confidence: 99%
“…Underdosing is a concern with both CQ and ACTs, potentially leading to inadequate clinical and parasitic responses [ 113 , 118 ]. The total recommended dose of chloroquine in children is 25 mg/kg over 3 days; however, owing to the unavailability of scales to weigh patients in many endemic regions, chloroquine is sometimes dispensed based on age, a practice which may lead to suboptimal dosing [ 115 , 119 ]. Additionally, to achieve clinical cure, prevent relapse, and limit transmission, dormant hypnozoites must be treated [ 81 , 120 ].…”
Section: Resultsmentioning
confidence: 99%