Dosimetric analysis and experimental setup design for in-vivo irradiation with a Plasma Focus device

A Plasma Focus device as ultra-high dose rate pulsed radiation source. Part II: X-ray pulses characterization

“…As shown in (Isolan et al, 2019), this capability of MCNP6, together with the actually validated model of the PFMA#3, has been proven already useful and in-depth studies are under way. Moreover, with respect to deep X-ray therapy applications, also the application of a Laue-Lens (Guidi et al, 2016) to the device could be useful for focusing the X-ray produced even in deep in tissues, organs or different targets, exceeding the limits dictated by the relatively photons low energies.…”

“…10, confirmed that a pulsed X-ray source able to deliver one Gy per pulse was well characterized and technically feasible. An immediate application just for tests and radiobiological studies, also for in-vivo tests, can be easily devised along the same research path already defined (Isolan et al, 2019). The spectral evaluations and measurements and the dosimetric estimates here discussed, could be considered for the design of in-vivo irradiations with the support of some new features of the MCNP6 code, that can handle unstructured mesh (UM) models directly coming from CT scans (Isolan et al, 2019;Pelowitz, 2014;Martz, 2014;Sumini et al 2019 ).…”

“…We used that passive dosimetric system to record the delivered dose due to the extremely short pulses, that allow a very high dose rate. Any other devices (with the exception of the TLDs (Isolan et al, 2019), that are more effective for point-wise evaluations) are not able to follow the delivery phase, as outlined also by other researchers working of fast radiation sources (Favaudon et al, 2014). Such short and intense pulses couldn't be properly detected by active dosimetric or revelation systems (e.g.…”

“…The simulation results have been benchmarked with the outcome of an experimental campaign, performed with the setup shown in Figs. 1 and 3 and with the brass target and fully validated in (Isolan et al, 2019).…”