Dosimetric aspects of 166Ho brachytherapy biodegradable glass seed

Hosseini, Seyed Hossein; Enferadi, Milad; Sadeghi, Mahdi

doi:10.1016/j.apradiso.2012.12.002

Cited by 17 publications

(12 citation statements)

References 35 publications

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“…34 The ITS 3.0-style energy indexing algorithm was selected over the inherent MCNP-style algorithm through an option in the DBCN card because previously published works have shown that the ITS 3.0-style algorithm gives results closer to those achieved through experimentation. 6 , 34 , 35 Here in this study, the previously published study for a 142 Pr beta emitter source was applied as a benchmark for validation of our simulation method and dose calculation. 36 …”

Section: Methodsmentioning

confidence: 99%

“…A variety of radioisotopes, such as Iodine-131, Yttrium-90, Rhenium-188, Holmium-166 etc, are applied for this purpose . 5 , 6 Brachytherapy is a type of internal radiotherapy that places solid radioactive sources in or adjacent to target tissues. In this study, a beta-emitting 188 Re biodegradable glass seed is proposed for the brachytherapy treatment of small hepatocellular carcinomas.…”

Section: Introductionmentioning

confidence: 99%

“…Previous works showed that the high degradability of bioactive glasses can be produced by the sol-gel technique. 6 , 27 – 29 These bioglasses interact with the surrounding tissue in situ and can be absorbed by body after about 7 months. 19 , 21 , 30 …”

Section: Introductionmentioning

confidence: 99%

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Evaluation of a Proposed Biodegradable 188Re Source for Brachytherapy Application

2015

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This study aimed to evaluate dosimetric characteristics based on Monte Carlo (MC) simulations for a proposed beta emitter bioglass 188Re seed for internal radiotherapy applications.The bioactive glass seed has been developed using the sol-gel technique. The simulations were performed for the seed using MC radiation transport code to investigate the dosimetric factors recommended by the AAPM Task Group 60 (TG-60).Dose distributions due to the beta and photon radiation were predicted at different radial distances surrounding the source. The dose rate in water at the reference point was calculated to be 7.43 ± 0.5 cGy/h/μCi. The dosimetric factors consisting of the reference point dose rate, D(r0,θ0), the radial dose function, g(r), the 2-dimensional anisotropy function, F(r,θ), the 1-dimensional anisotropy function, φan(r), and the R90 quantity were estimated and compared with several available beta-emitting sources.The element 188Re incorporated in bioactive glasses produced by the sol-gel technique provides a suitable solution for producing new materials for seed implants applied to brachytherapy applications in prostate and liver cancers treatment. Dose distribution of 188Re seed was greater isotropic than other commercially attainable encapsulated seeds, since it has no end weld to attenuate radiation.The beta radiation-emitting 188Re source provides high doses of local radiation to the tumor tissue and the short range of the beta particles limit damage to the adjacent normal tissue.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of a Proposed Biodegradable 188Re Source for Brachytherapy Application

2015

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“…It was shown that the spatial dose distribution of 166 Ho was confined to the implanted volume, whereas this is not the case for brachytherapy using iridium-192, which is frequently used (de Campos et al 2016). Monte Carlo simulations (Hosseini et al 2013) and MIRD methodology (Valente and Campos 2010) have been used to determine the range and total absorbed dose of 166 Ho-labelled ceramic seeds. The results were compared with seeds containing 32 P, 90 Y (Hosseini et al 2013) or samarium-132 ( 132 Sm).…”

Section: Intratumoural Applicationsmentioning

confidence: 99%

The various therapeutic applications of the medical isotope holmium-166: a narrative review

Klaassen¹,

Arntz²,

Arranja

et al. 2019

EJNMMI radiopharm. chem.

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Over the years, a broad spectrum of applications of the radionuclide holmium-166 as a medical isotope has been established. The isotope holmium-166 is attractive as it emits high-energy beta radiation which can be used for a therapeutic effect and gamma radiation which can be used for nuclear imaging purposes. Furthermore, holmium-165 can be visualized by MRI because of its paramagnetic properties and by CT because of its high density. Since holmium-165 has a natural abundance of 100%, the only by-product is metastable holmium-166 and no costly chemical purification steps are necessary for production of nuclear reactor derived holmium-166. Several compounds labelled with holmium-166 are now used in patients, such Ho 166 -labelled microspheres for liver malignancies, Ho 166 -labelled chitosan for hepatocellular carcinoma (HCC) and [ 166 Ho]Ho DOTMP for bone metastases. The outcomes in patients are very promising, making this isotope more and more interesting for applications in interventional oncology. Both drugs as well as medical devices labelled with radioactive holmium are used for internal radiotherapy. One of the treatment possibilities is direct intratumoural treatment, in which the radioactive compound is injected with a needle directly into the tumour. Numerous other applications have been developed, like patches for treatment of skin cancer and holmium labelled antibodies and peptides. The second major application that is currently clinically applied is selective internal radiation therapy (SIRT, also called radioembolization), a novel treatment option for liver malignancies. This review discusses medical drugs and medical devices based on the therapeutic radionuclide holmium-166.

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“…Indeed, the very first work reporting bioactive glasses-containing 153 Sm was proposed by Roberto and colleagues, 10,11 and since then other works proposed similar systems but containing holmium, rhenium, ytterbium, and yttrium. 3,4,[12][13][14][15][16] The antioxidant potential of cerium incorporated in bioactive glasses was also reported in the literature, which is one of the most relevant studies in the field since they established a correlation between cerium oxidation in the glass structure and biological properties. [17][18][19][20] In a previous study, 21 we comprehensively studied the structure of bioactive glasses containing gadolinium and ytterbium aiming to understand the role of rare earth in the glass structure.…”

mentioning

confidence: 99%

Dissolution, bioactivity behavior, and cytotoxicity of rare earth‐containing bioactive glasses (RE = Gd, Yb)

Zambanini

Borges

Faria

et al. 2019

Int J Applied Ceramic Tech

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Rare earth‐containing bioactive glasses (RE‐BGs) have been poorly explored in the biomaterials field, although RE has optical, nuclear, and magnetic properties that could be used in different biomedical applications. In order to verify whether these glasses can be promising as biomaterials, we studied the dissolution, bioactivity, and cytotoxicity of RE‐BGs based on the SiO2–Na2O–CaO–P2O5–RE2O3 (RE = Gd, Yb) system. The glasses were obtained by melting‐quenching and their particle size was determined by laser diffraction. Their dissolution behavior was studied in Tris‐HCl, while bioactivity was performed in simulated body fluid solution under physiological conditions during several periods. The cytotoxicity test was performed using glass‐derived conditioned medium and mesenchymal stem cell derived from deciduous teeth. The dissolution results showed that the glasses dissolved under two different kinetics, which are lower for rare earth‐containing glasses, due to the more covalent character of Si–O–RE bonds. The bioactivity results evidenced that all glasses showed bioactivity after 24 hours. However, gadolinium and ytterbium promoted a more calcium phosphate deposition, which contrasts with the slower dissolution kinetics of rare earth‐containing glasses. All the glasses were considered biocompatible, showing cell viability higher than 80%. The overall results showed that RE‐BGs are promising materials for applications that require bioactivity and/or biocompatibility.

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Dosimetric aspects of 166Ho brachytherapy biodegradable glass seed

Cited by 17 publications

References 35 publications

Evaluation of a Proposed Biodegradable 188Re Source for Brachytherapy Application

Evaluation of a Proposed Biodegradable 188Re Source for Brachytherapy Application

The various therapeutic applications of the medical isotope holmium-166: a narrative review

Dissolution, bioactivity behavior, and cytotoxicity of rare earth‐containing bioactive glasses (RE = Gd, Yb)

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