Dosimetric assessment of the mono and dual-isocentric VMAT technique based on flattening filter-free beams for SBRT with non-contiguous spinal targets

Dwivedi, Shekhar; Kansal, Sandeep; Shukla, Jooli; Bharati, Avinav; Dangwal, Vinod Kumar

doi:10.1016/j.meddos.2023.01.005

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…These results are in line with a recent study that compared the dosimetric evaluation of mono‐ and dual‐isocentric VMAT techniques for non‐contiguous spine SBRT. 27 The additional coplanar half arcs of iso2 may be beneficial in terms of increasing treatment angles and delivering an ideal PTV dose distribution while minimizing exposure to nearby OARs.…”

Section: Discussionmentioning

confidence: 99%

Single isocenter versus dual isocenter treatment using flattening filter‐free and jaw‐tracking volumetrically modulated arc therapy for boot‐shaped lung cancer: Evaluation of dosimetric and feasibility

Zhang,

Cheng,

et al. 2024

J Applied Clin Med Phys

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BackgroundTo determine whether a dual‐isocenter volumetrically modulated arc therapy (VMAT) technique results in lower normal pulmonary dosage compared to a traditional single isocenter technique for boot‐shaped lung cancer.MethodsA cohort of 15 patients with advanced peripheral or central lung cancer who had metastases in the mediastinum and supraclavicular lymph nodes was randomly selected for this retrospective study. VMAT plans were generated for each patient using two different beam alignment techniques with the 6‐MV flattening filter‐free (FFF) photon beam: single‐isocenter jaw‐tracking VMAT based on the Varian TrueBeam linear accelerator (S‐TV), and dual‐isocenter VMAT based on both TrueBeam (D‐TV) and Halcyon linear accelerator (D‐HV). For all 45 treatment plans, planning target volume (PTV) dose coverage, conformity/homogeneity index (CI/HI), mean heart dose (MHD), mean lung dose (MLD) and the total lung tissue receiving 5, 20, 30 Gy (V5, V20, V30) were evaluated. The monitor units (MUs), delivery time, and plan quality assurance (QA) results were recorded.ResultsThe quality of the objectives of the three plans was comparable to each other. In comparison with S‐TV, D‐TV and D‐HV improved the CI and HI of the PTV (p < 0.05). The MLD was 13.84 ± 1.44 Gy (mean ± SD) for D‐TV, 14.22 ± 1.30 Gy and 14.16 ± 1.42 Gy for S‐TV and D‐HV, respectively. Lungs‐V5Gy was 50.78 ± 6.24%, 52.00 ± 7.32% and 53.36 ± 8.48%, Lungs‐V20Gy was 23.72 ± 2.27%, 26.18 ± 2.86% and 24.96 ± 3.09%, Lungs‐V30Gy was 15.69 ± 1.76%, 17.20 ± 1.72% and 16.52 ± 2.07%. Compared to S‐TV, D‐TV provided statistically significant better protection for the total lung, with the exception of the lungs‐V5. All plans passed QA according the gamma criteria of 3%/3 mm.ConclusionsTaking into account the dosimetric results and published clinical data on radiation‐induced pulmonary injury, dual‐isocenter jaw‐tracking VMAT may be the optimal choice for treating boot‐shaped lung cancer.

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Section: Discussionmentioning

confidence: 99%

Single isocenter versus dual isocenter treatment using flattening filter‐free and jaw‐tracking volumetrically modulated arc therapy for boot‐shaped lung cancer: Evaluation of dosimetric and feasibility

Zhang,

Cheng,

et al. 2024

J Applied Clin Med Phys

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Application of dose-gradient function in reducing radiation induced lung injury in breast cancer radiotherapy

Bai,

Song,

et al. 2024

Journal of X-Ray Science and Technology: Clinical Applications

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OBJECTIVE: Try to create a dose gradient function (DGF) and test its effectiveness in reducing radiation induced lung injury in breast cancer radiotherapy. MATERIALS AND METHODS: Radiotherapy plans of 30 patients after breast-conserving surgery were included in the study. The dose gradient function was defined as D G H = V D V p 3 , then the area under the DGF curve of each plan was calculated in rectangular coordinate system, and the minimum area was used as the trigger factor, and other plans were triggered to optimize for area reduction. The dosimetric parameters of target area and organs at risk in 30 cases before and after re-optimization were compared. RESULTS: On the premise of ensuring that the target dose met the clinical requirements, the trigger factor obtained based on DGF could further reduce the V5, V10, V20, V30 and mean lung dose (MLD) of the ipsilateral lung in breast cancer radiotherapy, P < 0.01. And the D2cc and mean heart dose (MHD) of the heart were also reduced, P < 0.01. Besides, the NTCPs of the ipsilateral lung and the heart were also reduced, P < 0.01. CONCLUSION: The trigger factor obtained based on DGF is efficient in reducing radiation induced lung injury in breast cancer radiotherapy.

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Dosimetric assessment of the mono and dual-isocentric VMAT technique based on flattening filter-free beams for SBRT with non-contiguous spinal targets

Cited by 2 publications

References 16 publications

Single isocenter versus dual isocenter treatment using flattening filter‐free and jaw‐tracking volumetrically modulated arc therapy for boot‐shaped lung cancer: Evaluation of dosimetric and feasibility

Single isocenter versus dual isocenter treatment using flattening filter‐free and jaw‐tracking volumetrically modulated arc therapy for boot‐shaped lung cancer: Evaluation of dosimetric and feasibility

Application of dose-gradient function in reducing radiation induced lung injury in breast cancer radiotherapy

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