Dosimetric comparison of computed tomography-guided iodine-125 seed implantation assisted with and without three-dimensional printing non-coplanar template in locally recurrent rectal cancer: a propensity score matching study

Wang, Lu; Wang, Hao; Jiang, Yuliang; Ji, Zhe; Guo, Fuxin; Jiang, Ping; Qiu, Bin; Sun, Haitao; Fan, Jia; Li, Weiyan; Wang, Junjie

doi:10.5114/jcb.2021.103582

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…Different from the previous studies in which the SABT was performed with free hand guided by CT, in our study, 9 patients were treated with SABT assisted by the 3D-printing template and guided by the CT. Wang et al reported that the template assistance signi cantly improved the accuracy and e cacy of SABT for the recurrent rectal cancer (30). In this study, the 3D-template-assisted and CT-guided SABT showed a trend of better local control compared with CT-guided SABT, but the differences were insigni cant (HR, 0.42, P=0.410) possibly due to that the sample size of the patients receiving advanced SABT was small.…”

Section: Adverse Eventsmentioning

confidence: 61%

Long-term outcomes of stereotactic ablative brachytherapy for recurrent aggressive fibromatosis: an eight-year retrospective multicenter study

Chen,

He,

Yan

et al. 2023

Preprint

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Background Aggressive fibromatosis (AF) was characterized by a high potential of recurrence even following initial definitive treatment. There were considerable controversies regarding the management of recurrent AF. This study aimed to explore the long-term outcomes of iodine-125 (I-125) seed stereotactic ablative brachytherapy (SABT) for recurrent AF. Methods A multicenter retrospective study reviewed 38 recurrent AF patients receiving I-125 seed SABT from July 2013 to July 2021.The clinical outcomes including overall response rate (ORR), disease control rate (DCR), local control time (LCT), overall survival (OS), adverse events (AEs), and symptom relief rate were statistically assessed. Results The ORR and DCR reached 76.3% and 100.0% respectively. The 3-, 5 and 9-year LCT rates were 81.0%, 68.6% and 62.3% respectively. The 3-, 5 and 9-year OS rates reached 94.5%, 84.8% and 60.4% respectively. Multivariate analyses showed that smaller tumor volume and higher dose were significantly positive prognostic factors of LCT (P = 0.034, P = 0.047). Prognostic factors of OS were not found. 20 (52.6%) patients presented with various symptoms at diagnosis, of which 90% (18 patients) achieved complete or partial relief after SABT. The AEs were generally graded ≤ 1 and well-tolerated. Conclusions SABT was an effective and safe alternative treatment for recurrent AF with high safety.

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Section: Adverse Eventsmentioning

confidence: 61%

Long-term outcomes of stereotactic ablative brachytherapy for recurrent aggressive fibromatosis: an eight-year retrospective multicenter study

Chen,

He,

Yan

et al. 2023

Preprint

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“…22,23 Furthermore, the anatomy is distorted because of the intervention of the template and applicator, making preplanning necessary to achieve optimal needle track and isodose distribution. Several articles have studied the use of a 3D-printed template for particle therapy, [24][25][26] proposing the superiority of exact orientation and localization of inserted needles and considering it a result-oriented and accurate auxiliary tool in brachytherapy. In this study, we utilized an offline preplan based on CT images 1 week before the treatment to design and print the template.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of preplan‐based three‐dimensional individual template‐guided brachytherapy compared to freehand implantation

Zhang

Sun

et al. 2022

J Applied Clin Med Phys

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Image‐guided adaptive intracavitary/interstitial brachytherapy (IC/IS IGABT) has exhibited superior dosimetry advantage and local control for locally advanced cervical cancer (LACC). Our group designed a type of cylindrical three‐dimensional (3D) printed vaginal template combining an intracavitary applicator with straight and oblique interstitial needles according to the preplan on computed tomography images. This work aimed to research the consistency of the preplan with the treatment plan at every fraction to verify the practical guiding significance of the preplan. We also investigated the difference between 3D‐printed template‐guided implantation compared with freehand implantation for LACC. Twenty‐six patients were treated with 3D‐printed individual templates (3D template group), and 20 patients were treated by using freehand insertion (freehand group). Patients in the 3D template group would take a preplan one week before treatment to design and print the individual template, while the freehand group did not. All patients accepted volumetric rotational intensity‐modulated radiotherapy at a dose of 49.4 Gy in 26 fractions and subsequent brachytherapy at a dose of 26 Gy in four fractions. All analyses were performed by utilizing SPSS 26. The insertion depth was decreased in fractions 1 and 4 compared with the preplan. None of the dose volume histogram parameters of fractions 1–3, nor the D2cc of bladder and bowel at fraction 4 were barely changed compared with the preplan. The D90 and D98 of the high‐risk clinical target volume in the 3D template group were statistically higher than those in the freehand group (p < 0.01). The D2cc of the rectum, bladder, bowel, and sigmoid in the 3D template group were all lower than those in the freehand group (p < 0.01). The preplan in this research is consistent with treatment plans, which is important to ensure the feasibility of applying a 3D‐printed template in brachytherapy. The 3D‐printed individual guidance template was an effective method in brachytherapy for locally advanced cervical cancer.

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“…The results from previous studies and ours suggested that SABT had a good efficacy for HNACC. Interestingly, the local control seemed better in our and Zhang’s study than in Ashamalla’s study, which was probably attributed to the application of template and CT. Our previous work indicated that template assistance significantly improved the accuracy and efficacy of SABT [ 30 ]. Additionally, 3D-PNCT is superior to the 3D-PCT in some aspects.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Outcomes of Personalized Stereotactic Ablative Brachytherapy for Recurrent Head and Neck Adenoid Cystic Carcinoma after Surgery or External Beam Radiotherapy: A 9-Year Study

Chen

Dai

Jiang

et al. 2021

JPM

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The management of recurrent head and neck adenoid cystic carcinoma (HNACC) remains a problematic challenge. This study aims to evaluate the long-term outcomes of personalized stereotactic ablative brachytherapy (SABT) as a salvage treatment for recurrent HNACC after surgery or external beam radiotherapy (EBRT). 21 patients with recurrent HNACC after surgery or EBRT successfully underwent iodine-125 (I-125) seed SABT from May 2011 to November 2019. The objective response rate (ORR), disease control rate (DCR), local control time (LCT), overall survival (OS), symptomatic relief and adverse events (AEs) were analyzed. Following SABT, the ORR and DCR were 85.7% and 100%, respectively. The 3-, and 5-year LCT rates were 68.8% and 55.1%, respectively, and the 3- and 5-year OS rates were 85.9% and 66.2%, respectively. Furthermore, univariate analyses showed that higher D90 (>137.1 Gy) was a strong positive prognostic factor of LCT (p < 0.05). The pain disappeared in one patient 3 months after SABT and partial pain improvement was observed in nine patients 1 to 6 months after SABT. Additionally, dyspnea was relieved in one patient with the tumor involving the trachea. The major AEs were mild intraoperative hemorrhage and skin/mucosal toxicities which were generally graded ≤2 and well-tolerated. Personalized SABT was an effective and safe alternative option for recurrent HNACC after the previous failure of surgery or EBRT. The parameter of D90 may influence the local control.

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Dosimetric comparison of computed tomography-guided iodine-125 seed implantation assisted with and without three-dimensional printing non-coplanar template in locally recurrent rectal cancer: a propensity score matching study

Cited by 6 publications

References 24 publications

Long-term outcomes of stereotactic ablative brachytherapy for recurrent aggressive fibromatosis: an eight-year retrospective multicenter study

Long-term outcomes of stereotactic ablative brachytherapy for recurrent aggressive fibromatosis: an eight-year retrospective multicenter study

Characteristics of preplan‐based three‐dimensional individual template‐guided brachytherapy compared to freehand implantation

Long-Term Outcomes of Personalized Stereotactic Ablative Brachytherapy for Recurrent Head and Neck Adenoid Cystic Carcinoma after Surgery or External Beam Radiotherapy: A 9-Year Study

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