Dosimetric effect of respiratory motion in external beam radiotherapy of the lung

Mechalakos, James; Yorke, Ellen; Mageras, G.; Hertanto, Agung; Jackson, Andrew; Obcemea, Ceferino; Rosenzweig, Kenneth E.; Ling, C. Clifton

doi:10.1016/j.radonc.2004.01.011

Cited by 50 publications

(26 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Adding increased confidence in localizing a target within the lung can offer a reduction in PTV margins in an effort to spare healthy tissue. 26 In conclusion, our study shows variable radii around different points in the lung where a fiducial would follow a …”

Section: Discussionmentioning

confidence: 54%

The correlation of tissue motion within the lung: implications on fiducial based treatments

et al. 2011

View full text Add to dashboard Cite

In radiation therapy many motion management and alignment techniques rely on the accuracy of an internal fiducial acting as a surrogate for target motion within the lung. Although fiducials are routinely used as surrogates for tumor motion, the extent to which varying spatial locations in the lung move similarly to other locations has yet to be quantitatively analyzed. In an attempt to analyze the motion correlation throughout the lung, ten primary lung cancer patients underwent IRB-approved 4DCT scans in the supine position. Deformable registration produced motion vectors for each voxel between exhalation and inhalation. Modeling was performed for each vector and all surrounding vectors within the lung in order to determine the mean 3D Euclidean distance necessary for an implanted fiducial to correlate with surrounding tissue motion to within 3 mm (left lower: 1.7 cm, left upper: 2.1 cm, right lower 1.6 cm, and right upper 2.9 cm). No general implantation rule of where to position a fiducial with respect to the tumor was found as the motion is highly patient and lobe specific. Correlation maps are presented showcasing spatial anisotropy of the motion of tissue surrounding the tumor.

show abstract

Section: Discussionmentioning

confidence: 54%

The correlation of tissue motion within the lung: implications on fiducial based treatments

et al. 2011

View full text Add to dashboard Cite

show abstract

“…In most of these studies, total doses vary from 30 to 66 Gy, in 6-to 22-Gy fractions, and the number of fractions from 3 to 10 [5][6][7][9][10][11][12][13]. Also at variance are views on defining the target volume and on dosage specification Further controversial issues have to do with which safety margins are required with reference to the GTV and how respiratory motion of a lung tumor can be accounted and compensated for [4].…”

Section: Discussionmentioning

confidence: 99%

Stereotactic, high single-dose irradiation of stage I non-small cell lung cancer (NSCLC) using four-dimensional CT scans for treatment planning

Fritz¹,

Kraus²,

Blaschke³

et al. 2008

Lung Cancer

View full text Add to dashboard Cite

“…Plusieurs types de maté riels ont é té testé s pour visualiser les mouvements externes thoraciques ou abdominaux tels qu'une ceinture avec capteur de pression, un faisceau laser ou un ré flecteur posé sur l'abdomen associé à une camé ra infrarouge [14,19,22]. Actuellement, les sytè mes RPM ® /Varian et Exactrac ® /Brainlab sont les plus utilisé s. Ces systè mes de mesure externe permettent une synchronisation en respiration libre sur une partie du cycle respiratoire.…”

Section: Visualisation Des Mouvements Externesunclassified

“…Les recherches se sont ensuite focalisé es sur les moyens d'agir sur la respiration des patients au cours de l'acquisition tomodensitomé trique et des sé ances de traitement. Les premiers travaux ont consisté à é valuer les mouvements respiratoires avec l'objectif de les inté grer dans les marges de sé curité mais cela entraî-nerait une irradiation excessive [1,12,22]. Langen et Jones pré sentaient, en 2001, une compilation d'é valuations et d'orientations mé thodologiques pour prendre en compte les mouvements internes [19].…”

Section: Introductionunclassified

Le contrôle de la respiration en radiothérapie

et al. 2007

View full text Add to dashboard Cite

Dosimetric effect of respiratory motion in external beam radiotherapy of the lung

Cited by 50 publications

References 22 publications

The correlation of tissue motion within the lung: implications on fiducial based treatments

The correlation of tissue motion within the lung: implications on fiducial based treatments

Stereotactic, high single-dose irradiation of stage I non-small cell lung cancer (NSCLC) using four-dimensional CT scans for treatment planning

Le contrôle de la respiration en radiothérapie

Contact Info

Product

Resources

About