Dosimetric Effect of Sparing the Primary Site for Oropharyngeal Squamous Cell Carcinoma After Transoral Laser Microsurgery

Fried, David; Lehman-Davis, Misty; Hackman, Trevor; Kostich, M.; Lian, Jun; Burkhardt, Katharin Deschesne; Chera, B.S.

doi:10.1016/j.ijrobp.2012.07.1250

Cited by 1 publication

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“…Recent series demonstrate decreasing mucosal doses (median 55 Gy) with low mucosal emergence rates (<10%), similar to that (3%) in this report. Even lower mucosal doses may warrant consideration for virus‐associated squamous cell CUP, perhaps even sparing the mucosa entirely and relying instead on dose “fall off” from treatment of the neck using an intensity‐modulated approach …”

Section: Discussionmentioning

confidence: 99%

p16 status, pathologic and clinical characteristics, biomolecular signature, and long‐term outcomes in head and neck squamous cell carcinomas of unknown primary

et al. 2014

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Background To report associations between p16 status, clinicopathologic characteristics, and outcomes for unknown primary head and neck squamous cell carcinoma (SCCUPS). Methods Specimens of SCCUPS were re-analyzed. HPV status was determined by p16 stain. A tissue microarray (TMA) was constructed to evaluate biomarkers potentially prognostic in HNSCC. Results A majority of the population (n = 26, 74%) was p16+. Prognostic factors benefitting survival were p16+ status (p < 0.0001), absence of macroscopic extracapsular extension [ECE] (p = 0.004), younger age (p = 0.01), and higher grade (p = 0.007). The prognostic implication of worse OS with macroscopic ECE (p = 0.009) remained significant when limited to p16+ patients (p=0.002). Exploratory TMA between unknown primary and controls suggested a biomolecular difference between SCCUPS and known-primary cancer. Conclusions The majority of SCCUPS patients were p16+, indicative of HPV association. p16 staining and ECE appear to be the most prognostic features in SCCUPS.

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Section: Discussionmentioning

confidence: 99%