Dosimetric parameters of the new design 103Pd brachytherapy source based on Monte Carlo study

Saidi, Pooneh; Sadeghi, Mahdi; Shirazi, Alireza; Tenreiro, Claudio

doi:10.1016/j.ejmp.2010.12.005

Cited by 16 publications

(10 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this work, the MCNP5 v1.51 Monte Carlo code [12][13][14][15][16][17][18] was employed to simulate the radiation transport of electron beams through the Siemens ONCOR Linac (Siemens Co. Germany) treatment head and water phantom based on the dimensions and materials provided by the manufacturer. The accelerator exit window, primary collimators, flattening filter, monitor chambers, Y-jaws, and X-jaws were simulated in the geometric section of the code.…”

Section: Monte Carlo Simulationmentioning

confidence: 99%

Verification of Experimental Virtual Electron Source Position by Using Monte Carlo

Ghasemi¹,

Azma²,

Arfaee³

et al. 2018

Pure and Applied Physics

Self Cite

View full text Add to dashboard Cite

Electron beams have an important role in the treatment of superficial and shallow cancers in modern radiotherapy [1]. Because of the electron interactions with the accelerator head materials including scattering foils, monitoring chambers, photon jaws, and the applicators, they may be thought of as emanating from the virtual source that is not in the real position of the accelerator exit window. The International Commission on Radiation Units and Measurements (ICRU) Report No. 35 [2] , defines an effective extended electron source as the source which when placed in a vacuum at some distance SSD from the phantom surface (Z=0) would produce exactly the same electron fluence at Z=0 as the actual beam. The distance from this source position to the patient's skin surface is called the effective SSD. To obtain an accurate dose calculation of electron beams, correction for measured effective SSD must be applied. In addition, effective SSD may be used to calculate output at extended SSD for corrections of central axis percentage depth dose (PDD) [3] , off-axis dose (OAD) values, output factors, and X-ray contamination [4]. Hence, it is essential that these corrections should be examined for each treatment unit prior to referral to treat at extended SSD using electron beams. The SSD eff is dependent on the electron energy and the field size used.

show abstract

Section: Monte Carlo Simulationmentioning

confidence: 99%

Verification of Experimental Virtual Electron Source Position by Using Monte Carlo

Ghasemi¹,

Azma²,

Arfaee³

et al. 2018

Pure and Applied Physics

Self Cite

View full text Add to dashboard Cite

show abstract

“…where D(r,/2) and D(1,/2) are the dose rates measured at distances of r and 1 cm, respectively, along the transverse axis of the source. G L (r,) is known as the geometry function that takes into account the effect of the distribution of radioactive material inside the capsule on the dose distribution [20]. The anisotropy function was calculated following the TG-43 recommendation as:…”

Section: Dosimetry Techniquementioning

confidence: 99%

Determination of the Dosimetric Characteristics of BATAN’s 125/I Source for Brachytherapy: An Experimental Study

2018

View full text Add to dashboard Cite

I brachytherapy sources with low photon energies have been widely used in treating tumors. According to American Association of Physicists in Medicine Task Group No. 43 (AAPM TG-43) recommendations, dosimetric characteristic of the new brachytherapy sources should be determined before clinical use. In this study, dosimetric characteristic of 125 I manufactured by BATAN have been determined through measurement by using Thermoluminescent Dosemeter (TLD) and gafchromic XR-QA2 film. The radial dose function measurements were performed at distances ranging from 0.5 to 10 cm from the source center. The anisotropy functions were measured at distances of 2, 3, and 5 cm from the source center for angles ranging from 0 to 90 degree in all quadrants. The results indicated that a dose rate constants measured with TLD and film are 1.05  8 % cGy.h-1 .U-1 and 1.01  8 % cGy.h-1 .U-1 , respectively. The radial dose function decreases along with the increasing distance from source and meets the 5 th order polynomial equation. The anisotropy function result shows that the anisotropy in dose distribution increases along the source axis. This measurement data are in agreement with the previous study on EGSnrc Monte Carlo result and have a similar pattern with IsoAid and GMS BT-125 commercial 125 I source.

show abstract

“…This can either be seen as the lipid entering β' or β i form, away from the metastable α (spherical shape). Considering temperatures kept above 70°C it can be assumed particle exhibiting the stable β i , however this can only be confirmed with further analysis of the particle [30][31][32].…”

Section: Effect Of Surfactants On Particle Sizementioning

confidence: 99%

SLNs can Serve as the New Brachytherapy Seed: Determining Influence of Surfactants on Particle Size of Solid Lipid Microparticles and Development of Hydrophobised Copper Nanoparticles for Potential Insertion

Mistry¹,

Sarker²

2016

J Chem Eng Process Technol

View full text Add to dashboard Cite

Solid lipid nanoparticles (SLNs) or technically speaking, larger solid lipid microparticles are emerging as a noninvasive technique for drug-delivery, carrying forward advantages of conventional nanostructured systems and eliminating their drawbacks. This study involves the analysis of solid lipid microparticles generated via hot high-shear homogenization technique with tristearin as the main lipid component and phosphate buffer (pH 7.00) as the aqueous phase (phase volume 0.2). This study aims to identify the effects of the chosen lipid, and four non-ionic surfactants (Tween®20, Tween®80, Lutrol F68 and Lutrol F127) on particle size of solid lipid microparticles. Samples generating particle sizes of less than 200 nm were further analysed via SEM to determine morphological characteristics of SLNs. SLN composition is crucial as it determines various chemical and physical properties of the particle itself. Firstly, selection of lipids is key, as it the major component of the particle. Lipids display different polymorphic transitions upon crystallization affecting loading efficiency, drug distribution, drug loading, particle size, particle shape and overall stability. Secondly, selection of surfactants is vital as they overcome stability problems with reducing surface tension, particle aggregation and steric interactions. The aim of this study was to determine the optimal functioning surfactant concentration that would produce particle sizes less than 200 nm. SLNs generated in this study displayed a reduced particle size (90-150 nm) when using 2% w/v Tween®80 plus 5:1 F68; higher molecular weight surfactant, with a low molecular weight poloxamer. Based on previous research, these results can be explained via the surfactant characteristics in solution. The length of the fatty acid chains associated with Tween®20 and 80 provide a potential behavioural pattern on the SLN; longer chains surrounding the SLN structure increase stability of the particle but also increase particle size. Poloxamer use is that of a co-surfactant, fulfilling what Tween® fails to complete. In which higher molecular weight poloxamers can potentially explain the large particle size as the longer PEO terminal chains protrude from the particle after its insertion.

show abstract

Dosimetric parameters of the new design 103Pd brachytherapy source based on Monte Carlo study

Cited by 16 publications

References 16 publications

Verification of Experimental Virtual Electron Source Position by Using Monte Carlo

Verification of Experimental Virtual Electron Source Position by Using Monte Carlo

Determination of the Dosimetric Characteristics of BATAN’s 125/I Source for Brachytherapy: An Experimental Study

SLNs can Serve as the New Brachytherapy Seed: Determining Influence of Surfactants on Particle Size of Solid Lipid Microparticles and Development of Hydrophobised Copper Nanoparticles for Potential Insertion

Contact Info

Product

Resources

About