Dosimetry at the Portuguese research reactor using thermoluminescence measurements and Monte Carlo calculations

Fernandes, A.C.; Gonçalves, I. C.; Santos, J.P.; Cardoso, J.; Santos, L.; Carvalho, Alexandra; Marques, J.G.; Kling, A.; Ramalho, A.; Osvay, M.

doi:10.1093/rpd/nci560

Cited by 8 publications

(2 citation statements)

References 15 publications

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“…TL properties such as the glow curve, reproducibility, gamma, thermal neutron and light sensitivities have been determined and compared to those of dosemeters applied in mixedfield dosimetry at various dose levels (TLD-100, TLD-700, TLD-700H, Al 2 O 3 : Mg, Y (D-3)) (Fernandes et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

TL properties of newly developed lithium tetraborate single crystals

Fernandes

Osvay²,

Santos

et al. 2008

Radiation Measurements

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Section: Introductionmentioning

confidence: 99%

TL properties of newly developed lithium tetraborate single crystals

Fernandes

Osvay²,

Santos

et al. 2008

Radiation Measurements

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“…The activation reaction 197 Au (n,γ) 198 Au was considered. Important data for this reaction include the following: a = 100.00%; M = 196.9665; T1/2 = 2.696 day; Eγ = 411.8044 keV; p γ = 95.56%; σ0 = 98.65b; I = 1550 b; g = 1.005 [ 32 , 33 ].…”

Section: Methodsmentioning

confidence: 99%

Exploring the Physical and Biological Aspects of BNCT with a Carboranylmethylbenzo[b]acridone Compound in U87 Glioblastoma Cells

Belchior¹,

Fernandes²,

Lamotte³

et al. 2022

IJMS

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Boron neutron capture therapy (BNCT) is a re-emerging technique for selectively killing tumor cells. Briefly, the mechanism can be described as follows: after the uptake of boron into cells, the thermal neutrons trigger the fission of the boron atoms, releasing the α-particles and recoiling lithium particles and high-energy photons that damage the cells. We performed a detailed study of the reactor dosimetry, cellular dose assessment, and radiobiological effects induced by BNCT in glioblastoma (GBM) cells. At maximum reactor power, neutron fluence rates were ϕ0 = 6.6 × 107 cm−2 s−1 (thermal) and θ = 2.4 × 104 cm−2 s−1 with a photon dose rate of 150 mGy·h−1. These values agreed with simulations to within 85% (thermal neutrons), 78% (epithermal neutrons), and 95% (photons), thereby validating the MCNPX model. The GEANT4 simulations, based on a realistic cell model and measured boron concentrations, showed that >95% of the dose in cells was due to the BNC reaction. Carboranylmethylbenzo[b]acridone (CMBA) is among the different proposed boron delivery agents that has shown promising properties due to its lower toxicity and important cellular uptake in U87 glioblastoma cells. In particular, the results obtained for CBMA reinforce radiobiological effects demonstrating that damage is mostly induced by the incorporated boron with negligible contribution from the culture medium and adjacent cells, evidencing extranuclear cell radiosensitivity.

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